PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media294382ArticlesСтатьиResearch ArticleBIOLOGICAL PREPARATIONS IN THERAPY OF INFLAMMATORY BOWEL DISEASES: REALITY AND PROSPECTSБиологические препараты в терапии воспалительных заболеваний кишечника: реальность и перспективыSkalinskayaM. IСкалинскаяМ. И

PhD in Medical Sciences, Associate Professor at the Department of Propaedeutics of Internal Diseases, Gastroenterology and Dietology

к.м.н., доцент кафедры пропедевтики внутренних болезней, гастроэнтерологии и диетологии

mskalinskaya@yahoo.comBakulinI. GБакулинИ. ГSkazyvaevaE. VСказываеваЕ. ВZhigalovaT. NЖигаловаТ. НRyndinK. NРындинК. НSolovyevM. VСоловьевМ. ВFSBEI HE NWSMU n.a. I.I. MechnikovФГБОУ ВО СЗГМУ им. И.И. МечниковаFSBMEI HE «Military Medical Academy n.a. S.M. Kirov» of the Ministry of Defense of the Russian FederationФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» МО РФ15122017245SNOS5 (2017)№S5 (2017)859327022023Copyright ©; 2017, Bionika MediaCopyright ©; 2017, ООО «Бионика Медиа»2017Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/294382

The etiology of inflammatory bowel diseases (IBDs) is unknown, and pathogenesis is not fully understood. To date, monoclonal antibodies to tumor necrosis factor a and antibodies to α4-β7 are available for patients with IBDs in the Russian Federation. But at present, the direction of targeted therapy is actively developing in the world: the experience of the use of these agents is accumulating; the search for new molecules that are capable of interrupting the inflammatory cascade and simultaneously having a high safety profile is continuing.

Этиология воспалительных заболеваний кишечника (ВЗК) неизвестна, а патогенез понятен не в полном объеме. На сегодняшний день для пациентов с ВЗК в Российской Федерации доступны моноклональные антитела к фактору некроза опухоли а и антитела против α4-β7. Но в настоящее время в мире активно развивается направление таргетной терапии: накапливается опыт применения первых препаратов, продолжается поиск новых молекул, способных прерывать воспалительный каскад и одновременно с этим имеющих высокий профиль безопасности.

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