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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">294559</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Functional gastrointestinal disorders in children: aspects of diagnosis and treatment</article-title><trans-title-group xml:lang="ru"><trans-title>Функциональные гастроинтестинальные нарушения у детей: аспекты диагностики и лечения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kildiyarova</surname><given-names>R. R</given-names></name><name xml:lang="ru"><surname>Кильдиярова</surname><given-names>Р. Р</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, Prof. at the Department of Propaedeutics of Children’s Diseases with the Course of Polyclinic Pediatrics</p></bio><bio xml:lang="ru"><p>д.м.н., проф. кафедры пропедевтики детских болезней с курсом поликлинической педиатрии</p></bio><email>Kildiyarova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gurov</surname><given-names>M. M</given-names></name><name xml:lang="ru"><surname>Гурова</surname><given-names>М. М</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Izhevsk State Medical Academy</institution></aff><aff><institution xml:lang="ru">Ижевская государственная медицинская академия</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Belgorod State National Research University</institution></aff><aff><institution xml:lang="ru">Белгородский государственный национальный исследовательский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2018</year></pub-date><volume>25</volume><issue>2</issue><issue-title xml:lang="en">NO2 (2018)</issue-title><issue-title xml:lang="ru">№2 (2018)</issue-title><fpage>36</fpage><lpage>41</lpage><history><date date-type="received" iso-8601-date="2023-02-27"><day>27</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, ООО «Бионика Медиа»</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/294559">https://journals.eco-vector.com/2073-4034/article/view/294559</self-uri><abstract xml:lang="en"><p>The purpose of this review - to provide a classification of functional gastrointestinal disorders in children considering Roman criteria IV, their prevalence, consequences, general pathogenetic mechanisms, diagnosis and treatment principles. Materials and Methods. Analysis of the literature data on the epidemiology of this category of diseases in children; classification according to the international classification of diseases; treatment taking into account modern views on the pathogenesis and actual possibilities of drug therapy. Conclusions. From the positions of the biopsychosocial model in the development of functional disorders, the role of disorders of muconasal homeostasis and microbial contamination is recognized. Taking into account the algorithmic approach to diagnostics, the role of pre- and probiotic drugs (synbiotics) in formation of an effective barrier microbiota of the intestine is shown; they helps to reduce the characteristic clinical manifestations, such as diarrhea or constipation, flatulence, and abdominal pain.</p></abstract><trans-abstract xml:lang="ru"><p>Цель настоящего обзора - представить классификацию функциональных гастроинтестинальных нарушений у детей в свете Римских критериев-IV, их распространенность, последствия, общие патогенетические механизмы, диагностику и принципы лечения. Материалы и методы. Анализ литературы по эпидемиологии данной категории заболеваний у детей; классификация, согласно Международной классификации болезней; лечение с учетом современных воззрений на патогенез и актуальных возможностей медикаментозной терапии. Заключение. С позиций биопсихосоциальной модели в развитии функциональных расстройств признается роль нарушений муконазального гомеостаза и микробной контаминации. С учетом алгоритмического подхода к диагностике показана роль пре- и пробиотических препаратов (синбиотиков) для формирования эффективной барьерной микробиоты кишечника, способствующих уменьшению характерных клинических проявлений в виде учащенного стула или запоров, метеоризма, болей в животе.</p></trans-abstract><kwd-group xml:lang="en"><kwd>functional gastrointestinal disorders</kwd><kwd>Roman criteria IV</kwd><kwd>biopsychosocial model</kwd><kwd>synbiotics</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>функциональные гастроинтестинальные нарушения</kwd><kwd>Римские критерии-IV</kwd><kwd>биопсихосоциальная модель</kwd><kwd>синбиотики</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Drossman D.A. The functional gastrointestinal disorders and the Rome III process. 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