PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media29799810.18565/pharmateca.2019.4.111-121ArticlesСтатьиResearch ArticleDo we know everything about the possibilities of metformin in the treatment of type 2 diabetes mellitus? Which of its combinations is the most studied, effective and available for the patient in the real practice of the endocrinologist?Все ли мы знаем о возможностях метформина в лечении сахарного диабета 2 типа? Какая из его комбинаций наиболее изучена, эффективна и доступна для пациента в реальной практике врача-эндокринолога?BiryukovaElena V.БирюковаЕ. В

MD, Professor

д.м.н., проф.

lena@obsudim.ruSolovyovaI. VСоловьеваИ. ВA.I. Yevdokimov Moscow State University of Medicine and DentistryМосковский государственный медико-стоматологический университет им. А.И. Евдокимова15042019264VOL 26, NO4 (2019)ТОМ 26, №4 (2019)11112128022023Copyright ©; 2019, Bionika MediaCopyright ©; 2019, ООО «Бионика Медиа»2019Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/297998

The incidence of type 2 diabetes mellitus (DM2) is growing steadily around the world, and the effectiveness of glycemic control in this disease is still insufficient. The pathogenetic mechanisms of DM2 are discussed. The important role of insulin resistance as a key element in the development of DM2 is emphasized. The molecular mechanisms of action of metformin are considered in detail; its glycemic and extraglycemic effects, and the place of this drug in modern therapy of type 2 diabetes are analyzed.

Заболеваемость сахарным диабетом 2 типа (СД2) неуклонно растет во всем мире, а эффективность контроля гликемии при этом заболевании все еще недостаточна. Обсуждаются патогенетические механизмы СД2. Подчеркивается важная роль инсулинорезистентности как ключевого звена развития СД2. Детально рассматриваются молекулярные механизмы действия метформина, анализируются его гликемические и внегликемические эффекты, место препарата в современной терапии СД2.

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