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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">312292</article-id><article-id pub-id-type="doi">10.18565/pharmateca.2019.11.95-100</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Pharmacotherapy of chronic obstructive pulmonary disease: how to make a choice?</article-title><trans-title-group xml:lang="ru"><trans-title>Фармакотерапия хронической обструктивной болезни легких: как сделать выбор?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Romanovskikh</surname><given-names>A. G</given-names></name><name xml:lang="ru"><surname>Романовских</surname><given-names>А. Г</given-names></name></name-alternatives><bio xml:lang="en"><p>PhD, Associate Professor at the Department of Pulmonology</p></bio><bio xml:lang="ru"><p>к.м.н., доцент кафедры пульмонологии</p></bio><email>anngerom@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Belotserkovskaya</surname><given-names>Yu. G</given-names></name><name xml:lang="ru"><surname>Белоцерковская</surname><given-names>Ю. Г</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Smirnov</surname><given-names>I. P</given-names></name><name xml:lang="ru"><surname>Смирнов</surname><given-names>И. П</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shvaiko</surname><given-names>S. N</given-names></name><name xml:lang="ru"><surname>Швайко</surname><given-names>С. Н</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Medical Academy of Continuous Professional Education</institution></aff><aff><institution xml:lang="ru">Российская медицинская академия непрерывного профессионального образования</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">S.P. Botkin City Clinical Hospital</institution></aff><aff><institution xml:lang="ru">Городская клиническая больница им. С.П. Боткина</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2019-10-20" publication-format="electronic"><day>20</day><month>10</month><year>2019</year></pub-date><volume>26</volume><issue>11</issue><issue-title xml:lang="en">VOL 26, NO11 (2019)</issue-title><issue-title xml:lang="ru">ТОМ 26, №11 (2019)</issue-title><fpage>95</fpage><lpage>100</lpage><history><date date-type="received" iso-8601-date="2023-03-03"><day>03</day><month>03</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2019, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2019, ООО «Бионика Медиа»</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/312292">https://journals.eco-vector.com/2073-4034/article/view/312292</self-uri><abstract xml:lang="en"><p>The practical choice of the optimal pharmacotherapeutic strategy for chronic obstructive pulmonary disease (COPD) is often quite complicated. To make a decision about the need to change the volume of therapy, a new concept for controlling COPD can be useful, providing a dynamic assessment of the severity of symptoms, and the frequency and severity of exacerbations as indicators of the stability of the disease as a result of treatment. This article discusses clinical examples of managing patients with inadequate control of COPD. It is emphasized that the priority pharmacotherapeutic strategy for COPD is the use of long-acting bronchodilators, primarily fixed combinations of long-acting @2-adrenoagonists and long-acting anticholinergics that provide optimal control of symptoms and reduce the frequency of exacerbations of the disease in the main patient population. With repeated exacerbations of COPD on the background of bronchodilator therapy, however, the inclusion of inhaled glucocorticosteroids in the treatment program of the disease should be considered.</p></abstract><trans-abstract xml:lang="ru"><p>Практический выбор оптимальной фармакотерапевтической стратегии при хронической обструктивной болезни легких (ХОБЛ) зачастую достаточно сложен. Для принятия решения о необходимости изменения объема терапии может быть полезной новая концепция контроля ХОБЛ, предусматривающая динамическую оценку степени выраженности симптомов, частоты и тяжести обострений как показателей стабильности течения заболевания в результате проводимого лечения. В представленной статье рассмотрены клинические примеры ведения пациентов с недостаточным уровнем контроля ХОБЛ. Подчеркивается, что приоритетной фармакотерапевтической стратегией при ХОБЛ является использование длительно действующих бронходилататоров, в первую очередь фиксированных комбинаций длительно действующих в2-адреноагонистов и длительно действующих антихолинергических препаратов, обеспечивающих оптимальный контроль над симптомами и уменьшение частоты обострений заболевания у основной популяции пациентов. Вместе с тем при повторных обострениях ХОБЛ на фоне бронхолитической терапии следует рассматривать вопрос о включении в программу терапии заболевания ингаляционных глюкокортикостероидов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>chronic obstructive pulmonary disease (COPD)</kwd><kwd>pharmacotherapy of COPD</kwd><kwd>control of COPD</kwd><kwd>vilanterol/umeclidinium</kwd><kwd>vilanterol/ fluticasone furoate</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>хроническая обструктивная болезнь легких (ХОБЛ)</kwd><kwd>фармакотерапия ХОБЛ</kwd><kwd>контроль ХОБЛ</kwd><kwd>вилантерол/умеклидиний</kwd><kwd>вилантерол/флутиказона фуроат</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease (Update 2019). 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