<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">312887</article-id><article-id pub-id-type="doi">10.18565/pharmateca.2020.11.73-76</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Clinical case of the use of a combination of paclitaxel and carboplatin in the treatment of metastatic urachus tumor</article-title><trans-title-group xml:lang="ru"><trans-title>Клинический случай применения комбинации паклитаксела и карбоплатина в терапии метастатической опухоли урахуса</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kunafina</surname><given-names>Regina I.</given-names></name><name xml:lang="ru"><surname>Кунафина</surname><given-names>Р. И</given-names></name></name-alternatives><bio xml:lang="en"><p>Oncologist, Head of the Department of Chemotherapy</p></bio><bio xml:lang="ru"><p>врач-онколог, зав. отделением ООПЛТ</p></bio><email>kunafinareg2017@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sakaeva</surname><given-names>D. D</given-names></name><name xml:lang="ru"><surname>Сакаева</surname><given-names>Д. Д</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Urmantsev</surname><given-names>M. F</given-names></name><name xml:lang="ru"><surname>Урманцев</surname><given-names>М. Ф</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Suleymanova</surname><given-names>R. R</given-names></name><name xml:lang="ru"><surname>Сулейманова</surname><given-names>Р. Р</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Bashkir State Medical University, BSMU Clinic</institution></aff><aff><institution xml:lang="ru">Башкирский государственный медицинский университет, Клиника БГМУ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2020-10-20" publication-format="electronic"><day>20</day><month>10</month><year>2020</year></pub-date><volume>27</volume><issue>11</issue><issue-title xml:lang="en">VOL 27, NO11 (2020)</issue-title><issue-title xml:lang="ru">ТОМ 27, №11 (2020)</issue-title><fpage>73</fpage><lpage>76</lpage><history><date date-type="received" iso-8601-date="2023-03-03"><day>03</day><month>03</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2020, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2020, ООО «Бионика Медиа»</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/312887">https://journals.eco-vector.com/2073-4034/article/view/312887</self-uri><abstract xml:lang="en"><p>Background. The detection rate of urachus cancer is 0.35-0.7% of all cases of oncological pathology of the bladder and only 0.01% of all malignant tumors. Due to the low prevalence of urachus tumors to date, there are no uniform recommendations for palliative chemotherapy for this nosology. Description of the clinical case. The article describes a case of treatment of a rare urachus tumor with a combination of paclitaxel and carboplatin with a response to therapy. Conclusion. Palliative chemotherapy with paclitaxel+carboplatin made it possible to stabilize the disease for 4 months and preserve the patient’s satisfactory quality of life.</p></abstract><trans-abstract xml:lang="ru"><p>Обоснование. Частота выявления рака урахуса составляет 0,35-0,70% от всех случаев онкологической патологии мочевого пузыря и только 0,01% от всех злокачественных опухолей. В связи с низкой распространенностью опухолей урахуса на сегодняшний день не существует единых рекомендаций по паллиативной химиотерапии этой нозологии. Описание клинического случая. В статье приведен случай лечения редкой опухоли первичного мочевого протока - урахуса комбинацией паклитаксела и карбоплатина с ответом на терапию. Заключение. Проведение паллиативной химиотерапии в режиме паклитаксел+карбоплатин позволило стабилизировать заболевание на 4 месяца и сохранить удолетворительное качество жизни пациента.</p></trans-abstract><kwd-group xml:lang="en"><kwd>malignant lesion of the urachus</kwd><kwd>urachus</kwd><kwd>metastases</kwd><kwd>palliative chemotherapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>злокачественное поражение мочевого протока</kwd><kwd>урахус</kwd><kwd>метастазы</kwd><kwd>паллиативная химиотерапия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Reuter V The Urothelial tract: Renal pelvis, ureter, urinary bladder and urethra. Philadelphia: Lippincott Williams and Wilkins. 2004. Р 2062-63.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Kumar N, Khosla D., Kumar R., et al. Urachal carcinoma: Clinicopathological features, treatment and outcome. J Cancer Res Ther. Doi: 10.4103/0973-1482.137955.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>3. Нюшко КМ, Алексеев Б.Я., Каприн А.Д. Рак урахуса. Онкология. Журнал им. П.А.Герцена. 2015;4(3):43-7.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Henly D.R., Farrow G.M., Zincke H. Urachal cancer: role of conservative surgery. Urol. 1993;42:635-39. Doi: 10.1016/0090-4295(93)90526-g.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Siefker-Radtke A.O., Gee J., Shen Y, et al. Multimodality management of urachal carcinoma: the M.D. Anderson Cancer Center experience. J Urol. 2003;169:1295-98. Doi: 10.1097/01. ju.0000054646.49381.01.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Sheldon C.A., Clayman R.V, Gonzalez R, et al. Malignant urachal lesions. J Urol. 1984;131(1):1-8 Doi: 10.1016/s0022-5347(17)50167-6.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Paul A.B., Hunt C.R., Harney J.M., et al. Stage 0 mucinous adenocarcinoma in situ of the urachus. J Clin Pathol. 1998;51:483-84. Doi: 10.1136/ jcp.51.6.483.</mixed-citation></ref></ref-list></back></article>
