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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">312963</article-id><article-id pub-id-type="doi">10.18565/pharmateca.2020.13.42-48</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Herniated disc resorption: a review of studies</article-title><trans-title-group xml:lang="ru"><trans-title>Резорбция грыжи межпозвонкового диска: обзор исследований</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tkachev</surname><given-names>A. M</given-names></name><name xml:lang="ru"><surname>Ткачев</surname><given-names>А. М</given-names></name></name-alternatives><email>tkachevclinic@mail.iu</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Epifanov</surname><given-names>A. V</given-names></name><name xml:lang="ru"><surname>Епифанов</surname><given-names>А. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Akarachkova</surname><given-names>E. S</given-names></name><name xml:lang="ru"><surname>Акарачкова</surname><given-names>Е. С</given-names></name></name-alternatives><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gordeeva</surname><given-names>I. E</given-names></name><name xml:lang="ru"><surname>Гордеева</surname><given-names>И. Е</given-names></name></name-alternatives><xref ref-type="aff" rid="aff5"/><xref ref-type="aff" rid="aff6"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Dr. Berezin Medical Institute</institution></aff><aff><institution xml:lang="ru">Лечебно-диагностический центр «Медицинский институт им. Березина Сергея»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Tkachev Clinic, Volgograd</institution></aff><aff><institution xml:lang="ru">Клиника Ткачева, Волгоград</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Tkachev Epifanov Clinic, Moscow</institution></aff><aff><institution xml:lang="ru">Клиника Ткачева Епифанова, Москва</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">International Society “Stress under Control"</institution></aff><aff><institution xml:lang="ru">Международное общество «Стресс под контролем»</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Dr. Berezin Medical Institute</institution></aff><aff><institution xml:lang="ru">Клиника Ткачева, Волгоград</institution></aff></aff-alternatives><aff id="aff6"><institution>Tkachev Clinic, Volgograd</institution></aff><pub-date date-type="pub" iso-8601-date="2020-11-20" publication-format="electronic"><day>20</day><month>11</month><year>2020</year></pub-date><volume>27</volume><issue>13</issue><issue-title xml:lang="en">VOL 27, NO13 (2020)</issue-title><issue-title xml:lang="ru">ТОМ 27, №13 (2020)</issue-title><fpage>42</fpage><lpage>48</lpage><history><date date-type="received" iso-8601-date="2023-03-03"><day>03</day><month>03</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2020, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2020, ООО «Бионика Медиа»</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/312963">https://journals.eco-vector.com/2073-4034/article/view/312963</self-uri><abstract xml:lang="en"><p>Currently, about a third of the population experiences back and neck pain. In this case, the most common cause is herniated interver-tebral discs (HIVD). Surgical treatment in the absence of severe neurological symptoms shows similar results with conservative ones, while in some patients the pain syndrome persists or recurs after surgery. Neuroimaging studies demonstrate the possibility of HIVD resorption in patients receiving conservative therapy. This article analyzes studies on resorption or regression of HIVD and the contributing factors. It has been shown that the large size of the HIVD, the age of 40-50 years, as well as the protrusion of disc tissues through the posterior longitudinal ligament, the presence of a free fragment (sequester) or MRI parameters (hyperintense signal in T2-weighted images; thickening of the gadolinium rim on contrast-enhanced MRI) remain favorable factors contributing to the HIVD regression. Currently, the incidence of resorption is 63%, and its time varies from 8.5 to 24 months. It was concluded that further research in order to better understanding of the HIVD regression mechanisms, search for regression markers, and search for methods stimulating this process is required.</p></abstract><trans-abstract xml:lang="ru"><p>В настоящее время около трети населения испытывают боль в спине и шее. При этом чаще всего причиной служат грыжи межпозвонковых дисков (ГМД). Хирургическое лечение в отсутствие тяжелой неврологической симптоматики показывает схожие результаты с консервативным, при этом у части пациентов после операции болевой синдром сохраняется или рецидивирует. Проведение нейровизуализационных исследований демонстрирует возможность резорбции ГМД у пациентов на фоне консервативной терапии. В данной статье проанализированы исследования, посвященные резорбции или регрессированию ГМД и факторам, которые ей способствуют. Показано, что большой размер ГМД, возраст 40-50 лет, а также выход дискового материала через заднюю продольную связку, наличие свободного фрагмента (секвестра) или параметры МРТ (гиперинтенсивный сигнал в Т2-режиме; утолщение гадолиниевого ободка при проведении МРТ с контрастным усилением) остаются благоприятными факторами, способствующими регрессированию ГМД. Частота встречаемости резорбции в настоящее время составляет 63%, а ее время варьируется от 8,5 до 24 месяцев. Сделан вывод, согласно которому необходимо проведение дальнейших исследований с целью более детального понимания механизмов регрессирования ГМД, поиска его маркеров, а также методов, способствующих стимуляции данного процесса.</p></trans-abstract><kwd-group xml:lang="en"><kwd>back pain</kwd><kwd>herniated intervertebral discs</kwd><kwd>herniated disc resorption</kwd><kwd>regression of disc herniation</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>боль в спине</kwd><kwd>грыжи межпозвонковых дисков</kwd><kwd>резорбция грыжи диска</kwd><kwd>регрессирование грыжи диска</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Hoy D, Bain C, Williams G, et al. A systematic review of the global prevalence of low back pain. Arth Rheum. 2012;64(6):2028-37. Doi: 10.1002/art.34347.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Schmidt C.O, Raspe H, Pfingsten M, et al. 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