PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media45641610.18565/pharmateca.2023.3.44-52ReviewsОбзорыReview ArticleProblems of pancreas transplantation and the role of bioengineered materials in long-term survival and functioning of islet cellsПроблемы трансплантации поджелудочной железы и роль биоинженерных материалов в долгосрочной выживаемости и функционировании островковых клетокhttps://orcid.org/0000-0003-0027-1786BulgakovaSvetlana V.БулгаковаСветлана В.
Russian Federation
l.a.sharonova@samsmu.ruhttps://orcid.org/0000-0001-8827-4919SharonovaLyudmila A.ШароноваЛюдмила Александровна
Russian Federation

Cand. Sci. (Med.), Associate Professor at the Department of Endocrinology and Geriatrics, Samara State Medical University, Samara, Russia

к.м.н., доцент кафедры эндокринологии и гериатрии, Самарский государственный медицинский университет, Самара, Россия

l.a.sharonova@samsmu.ruhttps://orcid.org/0000-0001-6678-6411DolgikhYuliya A.ДолгихЮлия А.
Russian Federation
l.a.sharonova@samsmu.ruhttps://orcid.org/0000-0002-5754-1057KosarevaOlga V.КосареваОльга В.
Russian Federation
l.a.sharonova@samsmu.ruhttps://orcid.org/0000-0003-0097-7252TrenevaEkaterina V.ТреневаЕкатерина В.
Russian Federation
l.a.sharonova@samsmu.ruhttps://orcid.org/0000-0003-4114-5233KurmaevDmitry P.КурмаевДмитрий П.
Russian Federation
l.a.sharonova@samsmu.ruSamara State Medical UniversityСамарский государственный медицинский университет2305202330344522305202323052023Copyright ©; 2023, Bionika MediaCopyright ©; 2023, ООО «Бионика Медиа»2023Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/456416

Replacement of β-cells by donor pancreas (transplantation or cell therapy may be a solution to a number of problems associated with the treatment of patients with type 1 diabetes mellitus. The article discusses the problems of transplantation of the pancreas and islet cells, the role of the extracellular matrix in maintaining the functional activity and survival of β-cells of the islets of the pancreas. Data on possible sources of insulin-producing cells and the evolution of transplantation methods are presented. The article discusses the features of biomaterials for bioengineered scaffolds aimed at protecting the graft from the recipient’s immune reactions, facilitating the exchange of vital molecules, improving the viability and metabolic activity of islet cells. The analysis of the advantages and disadvantages of encapsulating devices of various sizes, possible solutions to the issue of graft vascularization, as well as the prospects for the use of 3D-bioprinting of the pancreas.

Замена β-клеток с помощью трансплантации донорской поджелудочной железы (ПЖ) или клеточной терапии может быть решением ряда проблем, связанных с лечением пациентов с сахарным диабетом 1 типа. В статье обсуждаются проблемы трансплантации ПЖ и островковых клеток, роль внеклеточного матрикса в поддержании функциональной активности и выживании β-клеток островков ПЖ. Представлены данные о возможных источниках инсулин-продуцирующих клеток и эволюции методов трансплантации. В статье обсуждаются особенности биоматериалов для биоинженерных каркасов, направленных на защиту трансплантата от иммунных реакций реципиента, облегчение обмена жизненно важными молекулами, улучшение жизнеспособности и метаболической активности островковых клеток. Проведен анализ преимуществ и недостатков инкапсулирующих устройств различного размера, возможных решений вопроса васкуляризации трансплантата, а также перспектив применения 3D-биопечати ПЖ.

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