PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media46278610.18565/pharmateca.2023.1-2.214-220Dermatology/allergologyДерматология/аллергологияResearch ArticleA personalized approach to omalizumab therapy in patients with chronic spontaneous urticaria: case seriesПерсонифицированный подход к терапии омализумабом у пациентов с хронической спонтанной крапивницей: серия клинических случаевhttps://orcid.org/0000-0002-5103-2446PetukhovaAnna Yu.ПетуховаАнна Юрьевна
Russian Federation

Cand. Sci. (Med.), Headof the Outpatient Consultative Department of Allergology and Immunology

к.м.н., зав. амбулаторно-консультативным отделением аллергологии и иммунологии

anna-petuhova@mail.ruCentral City Clinical Hospital № 6Центральная городская клиническая больница № 615052023301/22142202805202328052023Copyright ©; 2023, Bionika MediaCopyright ©; 2023, ООО «Бионика Медиа»2023Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/462786

Chronic spontaneous urticaria (CSU) is one of the most common skin diseases and leads to a significant decrease in the quality of life of patients. In some cases, in the presence of angioedema of certain localizations, this disease can lead to life-threatening conditions. Patients whose CSU is not controlled by fourfold doses of non-sedating antihistamines require genetically engineered biological therapy (GEBT) with omalizumab. Wherein, it is not always possible to achieve complete control of CSU using standard doses of this drug. Current therapeutic strategies allow achieving a complete response to therapy by escalating doses of omalizumab. This article presents the clinical experience of successful personalized selection of GIBT in patients with severe CSU, refractory to standard treatment.

Хроническая спонтанная крапивница (ХСК) является одним из самых распространенных заболеваний кожи и ведет к существенному снижению качества жизни пациентов. В некоторых случаях при наличии ангиоотеков определенных локализаций данное заболевание может приводить к жизнеугрожающим состояниям. Пациентам, у которых ХСК не контролируется четырехкратными дозами неседативных антигистамииных препаратов, требуется генно-инженерная биологическая терапия (ГИБТ) омализумабом. При этом, применяя стандартные дозы данного лекарственного препарата, не всегда удается достигать полного контроля ХСК. Современные стратегии терапии позволяют добиваться полного ответа на терапию путем эскалации доз омализумаба. В данной статье представлен клинический опыт успешного персонифицированного подбора ГИБТ пациентам с тяжелой ХСК, рефрактерной к стандартному лечению.

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