<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">562795</article-id><article-id pub-id-type="doi">10.18565/pharmateca.2023.6-7.54-58</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Clinical experience</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинический опыт</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Pelvic extrusion in patients with cervical cancer: clinical experience</article-title><trans-title-group xml:lang="ru"><trans-title>Экзентрация малого таза у больных раком шейки матки: клинический опыт</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khakimov</surname><given-names>G. A.</given-names></name><name xml:lang="ru"><surname>Хакимов</surname><given-names>Г. А.</given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><email>hgg_doc@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4970-5429</contrib-id><name-alternatives><name xml:lang="en"><surname>Khakimova</surname><given-names>Gulnoz G.</given-names></name><name xml:lang="ru"><surname>Хакимова</surname><given-names>Гулноз Голибовна</given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.), Associate Professor at the Department of Pediatric Oncology, Oncologist-Chemotherapist</p></bio><bio xml:lang="ru"><p>к.м.н., доцент кафедры детской онкологии, онколог-химиотерапевт</p></bio><email>hgg_doc@mail.ru</email><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6984-4389</contrib-id><name-alternatives><name xml:lang="en"><surname>Musurmonov</surname><given-names>K. U.</given-names></name><name xml:lang="ru"><surname>Мусурмонов</surname><given-names>Х. У.</given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><email>hgg_doc@mail.ru</email><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9491-0413</contrib-id><name-alternatives><name xml:lang="en"><surname>Khakimova</surname><given-names>S. G.</given-names></name><name xml:lang="ru"><surname>Хакимова</surname><given-names>Ш. Г.</given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><email>hgg_doc@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4576-3223</contrib-id><name-alternatives><name xml:lang="en"><surname>Orifjonova</surname><given-names>G. P.</given-names></name><name xml:lang="ru"><surname>Орифжонова</surname><given-names>Г. П.</given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><email>hgg_doc@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Tashkent city Branch of the Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology</institution></aff><aff><institution xml:lang="ru">Ташкентский городской филиал Республиканского специализированного научно-практического медицинского центра онкологии и радиологии</institution></aff></aff-alternatives><aff id="aff2"><institution>Nano Medical Clinic</institution></aff><aff-alternatives id="aff3"><aff><institution xml:lang="en">Tashkent Pediatric Medical Institute</institution></aff><aff><institution xml:lang="ru">Ташкентский педиатрический медицинский институт</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-07-22" publication-format="electronic"><day>22</day><month>07</month><year>2023</year></pub-date><volume>30</volume><issue>6/7</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>54</fpage><lpage>58</lpage><history><date date-type="received" iso-8601-date="2023-07-21"><day>21</day><month>07</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-07-21"><day>21</day><month>07</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, ООО «Бионика Медиа»</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/562795">https://journals.eco-vector.com/2073-4034/article/view/562795</self-uri><abstract xml:lang="en"><p>Despite the achievements in performing small pelvic exenteration (SPE) in the world oncological practice, it still remains a debatable subject for practicing oncological surgeons. The main reasons for its unpopularity include technical complexity, high incidence of intra- and postoperative complications (60%), high postoperative mortality (30%), and problems in postoperative rehabilitation of patients [1–3]. This article provides an analysis of 20 SPEs (10 anterior; 10 total) in recurrent locally advanced forms of cervical cancer.</p></abstract><trans-abstract xml:lang="ru"><p>Несмотря на имеющиеся достижения при выполнении экзентерации малого таза (ЭМТ) в мировой онкологической практике, она до сих пор остается дискутабельным объектом практикующих хирургов-онкологов. К основным причинам ее непопулярности относятся техническая сложность, высокая частота интра- и послеоперационных осложнений (60%), высокая послеоперационная летальность (30%), проблемы послеоперационной реабилитации больных [1–3]. В данной статье приведен анализ 20 ЭМТ (10 – передних; 10 – тотальных) при рецидивирующих местнораспространенных формах рака шейки матки.</p></trans-abstract><kwd-group xml:lang="en"><kwd>cervical cancer</kwd><kwd>pelvic extrusion</kwd><kwd>overall survival</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак шейки матки</kwd><kwd>экзентрация малого таза</kwd><kwd>общая выживаемость</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Косенко И.А. Хирургическое вмешательство в лечении больных раком шейки матки с неблагоприятным прогнозом. Медицинская панорама. 2007;7:15–17. [Kosenko I.A. Surgical intervention in the treatment of patients with cervical cancer with an unfavorable prognosis. Meditsinskaya panorama. 2007;7:15–7. (In Russ.)].</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Marziona F., Torioni H., Abrao F. Exenteracaopelvica no cancer gine-cologico. J Bras Ginecol. 1992;102(9):339–42.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Bricker E.M. Bladder substitution after pelvic evisceration. Surg Clin North Am. 1950;1:17–183. Doi: 10.1016/s0039-6109(16)33147-4.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Петровский Б.В. Большая медицинская энциклопедия. М., 1986. Т. 27. С. 562–63. [Petrovsky B.V. Big medical encyclopedia. M., 1986. Vol. 27. P. 562–63. (In Russ.)].</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Brunschwig A. Complete excision of pelvic viscera for advanced carcinoma. Cancer. 1948;1:177–83. Doi: 10.1002/ 1097-0142(194807)1:2&lt;177::aid-cncr2820010203&gt;3.0.co;2-a.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Brunschwig A. Pelvic exenteration combined with resection of segments of bony pelvis. Surgery. 1969;65(3):417–20.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Hugh R.K. Treatment and results of recurrent cancer of corpus uteri in patients reseiving anterior and posterior total pelvic exenteration 1947–63. Cancer. 1968;22(5):949–55. Doi: 10.1002/1097-0142(196811)22:5&lt;949::aid-cncr2820220509&gt;3.0.co;2-7.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Лихтер М.С., Шелыгин Ю.А., Ачкасов С.И. Мультидисциплинарный подход к лечению больных колоректальным раком с вовлечением органов мочевыделительной системы. Хирургия. Журнал им. Н.И. Пирогова. 2012;12:34–9. [Likhter M.S., Shelygin Yu.A., Achkasov S.I. Multidisciplinary approach to the treatment of patients with colorectal cancer involving the organs of the urinary system. Khirurgiya. Zhurnal im. N.I. Pirogova. 2012;12:34–9. (In Russ.)].</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Одарюк Т.С. Эвисцерация таза при местнораспространенном раке прямой кишки и с прорастанием в мочевой пузырь. Хирургия. 1999;7:5–63. [Odaryuk T.S. Evisceration of the pelvis in locally advanced rectal cancer and with invasion into the bladder. Khirurgiya. 1999; 7:5–63. (In Russ.)].</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Симонов Н.Н. и др. Эффективность комбинированных резекций и экзентераций органов малого таза как этапа комплексного лечения распространенных злокачественных опухолей прямой кишки и женских гениталий. Вопросы онкологии. 2000;46(2):224–28. [Simonov N.N. Efficiency of combined resections and exenterations of the pelvic organs as a stage in the complex treatment of common malignant tumors of the rectum and female genitalia. Voprosy onkologii. 2000;46(2):224–28. (In Russ.)].</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Тимофеев Ю.М. и др. Тотальные эвисцерации малого таза при местно-распространенном раке прямой кишки. Российский онкологический журнал. 2004;5:25–7. [Timofeev Yu.M. Total evisceration of the small pelvis in locally advanced rectal cancer. Rossiiskii onkologicheskii zhurnal. 2004;5:25–7. (In Russ.)].</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Ильин К.А., Замятин А.В. Роль эвисцерации в лечении постлучевых рецидивов рака шейки матки на современном этапе. Онкогинекология. 2013;1:43–53. [Ilyin K.A., Zamyatin A.V. The role of evisceration in the treatment of post-radiation relapses of cervical cancer at the present stage. Onkoginekologiya. 2013;1:43–53. (In Russ.)].</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Майстренко Н.А., Хватов А.А., Учваткин Г.В. и др. Экзентрация малого таза в лечении местно-распространенных опухолей. Вестник хирургии. 2014;173(6):37–42. [Maistrenko N.A., Khvatov A.A., Uchvatkin G.V. et al. Pelvic exentration in the treatment of locally advanced tumors. Bulletin of Surgery. 2014;173(6):37–42. (In Russ.)].</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Grimes W.R., Stratton M. Pelvic Exenteration. [Updated 2022 Oct 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK563269/</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Brunschwig, A. What are the indications and results of pelvic exenteration? JAMA. 1965;194:274–81. Doi: 10.1001/jama.194.3.274.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Brown K.G.M., Solomon M.J., Koh C.E. Pelvic Exenteration Surgery: The Evolution of Radical Surgical Techniques for Advanced and Recurrent Pelvic Malignancy. Dis Colon Rectum. 2017;60(7):745–54. Doi: 10.1097/DCR.0000000000000839.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Хирш Х.А. Оперативная гинекология. М.: ГЭОТАР Медицина, 1999. 656 c. [Hirsch H.A. Operative gynecology. Moscow: GEOTAR Medicine, 1999. 656 p. (In Russ.)].</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Quyn A.J., Solomon M.J., Lee P.M., et al. Palliative Pelvic Exenteration: Clinical Outcomes and Quality of Life. Dis Colon Rectum. 2016;59(11):1005–10. Doi: 10.1097/DCR.0000000000000679.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Koh C.E., Solomon M.J., Brown K.G., et al. The Evolution of Pelvic Exenteration Practice at a Single Center: Lessons Learned from over 500 Cases. Dis Colon Rectum. 2017;60(6):627–35. doi: 10.1097/DCR.0000000000000825.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>PelvExCollaborative. Pelvic Exenteration for Advanced Nonrectal Pelvic Malignancy. Ann Surg. 2019;270(5):899–905. Doi: 10.1097/SLA.0000000000003533.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Waters P.S., Peacock O., Warrier S.K., et al. Evolution of pelvic exenteration surgery- resectional trends and survival outcomes over three decades. Eur J Surg Oncol. 2019;45(12):2325–33. Doi: 10.1016/j.ejso.2019.07.015.</mixed-citation></ref></ref-list></back></article>
