<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">562822</article-id><article-id pub-id-type="doi">10.18565/pharmateca.2023.6-7.121-124</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Clinical case</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинический разбор</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Combination of sarcoidosis and sigmoid colon cancer: a clinical observation</article-title><trans-title-group xml:lang="ru"><trans-title>Сочетание саркоидоза и рака сигмовидной кишки: клиническое наблюдение</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dmitrieva</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Дмитриева</surname><given-names>Н. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>elviramavlyavieva@mail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mavlyavieva</surname><given-names>Elvira R.</given-names></name><name xml:lang="ru"><surname>Мавлявиева</surname><given-names>Эльвира Рафаэльевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.), Head of the Operational and Information Department</p></bio><bio xml:lang="ru"><p>к.м.н., зав. оперативно-справочного отдела</p></bio><email>elviramavlyavieva@mail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chernikova</surname><given-names>Yu. V.</given-names></name><name xml:lang="ru"><surname>Черникова</surname><given-names>Ю. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>elviramavlyavieva@mail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fedotov</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Федотов</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>elviramavlyavieva@mail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mirilashvili</surname><given-names>T. Sh.</given-names></name><name xml:lang="ru"><surname>Мирилашвили</surname><given-names>Т. Ш.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>elviramavlyavieva@mail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Eramishantsev City Clinical Hospital of the Moscow Healthcare Department</institution></aff><aff><institution xml:lang="ru">ГКБ им. А.К. Ерамишанцева ДЗМ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-07-22" publication-format="electronic"><day>22</day><month>07</month><year>2023</year></pub-date><volume>30</volume><issue>6/7</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>121</fpage><lpage>124</lpage><history><date date-type="received" iso-8601-date="2023-07-22"><day>22</day><month>07</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-07-22"><day>22</day><month>07</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, ООО «Бионика Медиа»</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/562822">https://journals.eco-vector.com/2073-4034/article/view/562822</self-uri><abstract xml:lang="en"><p>Sarcoidosis is a benign systemic disease characterized by the formation of granulomas in almost all organs. A frequent combination of sarcoidosis and various neoplastic diseases has been noted. Differential diagnosis of sarcoidosis and malignancy is extremely difficult. Currently, there are no diagnostic methods, other than histological examination, to distinguish sarcoidosis from a tumor process. Biopsy with histological examination is the reliable method. In the considered clinical case, a combination of sarcoidosis and metastatic sigmoid colon cancer is presented. PET-CT revealed the same hypermetabolic activity in the cervical, supraclavicular, intrathoracic lymph nodes and metastases in the tissues of the anterior abdominal that did not allow differential diagnosis of sarcoidosis and metastatic process. Sarcoidosis was proven only by histological examination of the removed cervical lymph node; a number of radiological signs suggested sarcoidosis of the intrathoracic lymph nodes, but their histological examination was not performed. The presented case is intended to alert oncologists regarding sarcoidosis, which often accompanies a disseminated tumor process.</p></abstract><trans-abstract xml:lang="ru"><p>Саркоидоз является доброкачественным системным заболеванием, для которого характерно образование гранулем практически во всех органах. Отмечено частое сочетание саркоидоза и различных опухолевых заболеваний. Дифференциальная диагностика саркоидоза и злокачественной опухоли крайне трудна. В настоящее время не существует диагностических методов, кроме гистологического исследования, позволяющих отличать саркоидоз от опухолевого процесса. Единственным достоверным методом является биопсия с последующим гистологическим исследованием. В рассматриваемом клиническом случае представлено сочетание саркоидоза и метастатического рака сигмовидной кишки. При ПЭТ-КТ гиперметаболическая активность в шейных, надключичных, внутригрудных лимфоузлах и метастазах в тканях передней брюшной стенки была одинаковой и не позволяла проводить дифференциальную диагностику саркоидоза и метастатического процесса. Саркоидоз был доказан только при гистологическом исследовании удаленного шейного лимфоузла, ряд рентгенологических признаков заставил предположить саркоидоз внутригрудных лимфоузлов, однако их гистологическое исследование не проводилось. Представленный случай призван насторожить врачей-онкологов в отношении саркоидоза, который нередко сопутствует диссеминированному опухолевому процессу.</p></trans-abstract><kwd-group xml:lang="en"><kwd>sarcoidosis</kwd><kwd>sigmoid colon cancer</kwd><kwd>metastases</kwd><kwd>diagnosis of sarcoidosis</kwd><kwd>histological picture of sarcoidosis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>саркоидоз</kwd><kwd>рак сигмовидной кишки</kwd><kwd>метастазы</kwd><kwd>диагностика саркоидоза</kwd><kwd>гистологическая картина саркоидоза</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Brincker H., Wilbek E. The incidence of malignant tumours in patients with respiratory sarcoidosis. Br J Cancer. 1974;29:247–51. Doi: 10.1038/bjc.1974.64.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Boffetta P., Rabkin C.S., Gridley G. A cohort study of cancer among sarcoidosis patients. Int J Cancer. 2009;124:2697–700. Doi:10.1002/ijc.24261.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Hachisu Y., Koga Y., Kasama S., et al. Medicina (Kaunas). The Relationship between Tumor Development and Sarcoidosis in Aspects of Carcinogenesis before and after the Onset of Sarcoidosis. Medicina (Kaunas). 2022;58(6):768. Doi: 10.3390/medicina58060768.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Fujii T., et al. Adenocarcinoma of Ascending Colon Associated with Sarcoid Reaction in Regional Lymph Nodes. Case Rep Gastroenterol. 2010;4(1):118–23. doi: 10.1159/000275064.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Mohamadnejad M., et al. Adenocarcinoma of the colon associated with sarcoidosis. Med Gen Med. 2003;5(1):6.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Teh A, et al. Bone marrow sarcoidosis associated with long-term interferon-treatment for multiple sclerosis. Clinical Case Reports. 2016;4(11):1038–40.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Osborne G.E.N, Mallon E., Mayou S.C. Juvenile sarcoidosis after BCG vaccination. J Am Acad Dermatol. 2003;48(5):S99–S102. Doi: 10.1067/mjd.2003.158.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Danlos F.X., et al. Nivolumab-Induced Sarcoid-Like Granulomatous Reaction in a Patient With Advanced Melanoma. Chest. 2016;149(5):E133–36. Doi: 10.1016/j.chest.2015.10.082..</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Stanziola A.A., Caccavo G., De Rosa N., et al. Sarcoidosis and colon cancer: a possible association. Sarcoidosis Vasc Diffuse Lung Dis. 2018; 35(4):376–80. Doi: 10.36141/svdld.v35i4.7191.</mixed-citation></ref></ref-list></back></article>
