PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media62595810.18565/pharmateca.2023.13.77-84Pharmacological properties of drugsФармакологические свойства лекарствResearch ArticleMinoxidil: effectiveness and prospects for use in the treatment of androgenetic alopeciaМиноксидил: эффективность и перспективы использования в лечении андрогенной алопецииhttps://orcid.org/0000-0002-0238-6563ShatokhinaE. A.ШатохинаЕ. А.
Russian Federation

Dr. Sci. (Med.), Professor at the Department of Dermatovenereology and Cosmetology, Leading Researcher at the Department of Internal Medicine

д.м.н., профессор кафедры дерматовенерологии и косметологии, ведущий науч. сотр. отдела внутренних болезней

e.a.shatokhina@gmail.comhttps://orcid.org/0009-0002-8508-6300KlyushinaO. Yu.КлюшинаО. Ю.
Russian Federation
pharmateca@yandex.ruhttps://orcid.org/0009-0000-8395-734XMayransaevaS. R.МайрансаеваС. Р.
Russian Federation
pharmateca@yandex.ruCentral State Medical Academy of the Administrative Department of the President of the Russian FederationЦентральная государственная медицинская академия Управления делами Президента РФMedical Research and Educational Center, Lomonosov Moscow State UniversityМедицинский научно-образовательный центр МГУ им. М.В. Ломоносова04122023301377842401202424012024Copyright ©; 2023, Bionika MediaCopyright ©; 2023, ООО «Бионика Медиа»2023Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/625958

Androgenetic alopecia (AGA) is the most common hair loss condition affecting both men and women. The most common drug of choice in the treatment of AGA is minoxidil, which has vasodilating, anti-inflammatory and antiandrogenic properties; it is an inducer of the Wnt/β-catenin signaling pathway, and enhances the synthesis of growth factors. Minoxidil affects several pathogenesis of AGA at once, prolonging the anagen phase and reducing the telogen phase, enhancing DNA synthesis and stimulating proliferative processes. Currently, minoxidil is considered as a drug for both local and systemic therapy of AGA. Treatment methods with minoxidil in combination with finasteride, spironolactone, topical tretinoin, as well as platelet-rich plasma, low-intensity laser therapy and microneedling are of particular, which significantly expands the treatment options for patients with AGA.

Андрогенная алопеция (АГА) является наиболее распространенным заболеванием, связанным с выпадением волос, затрагивающим как мужчин, так и женщин. Наиболее часто препаратом выбора при лечении АГА является миноксидил, который обладает вазодилатирующим, противовоспалительным и антиандрогенным свойствами, является индуктором сигнального пути Wnt/β-катенина, усиливает синтез факторов роста. Миноксидил оказывает воздействие сразу на несколько путей патогенеза АГА, пролонгируя фазу анагена и сокращая фазу телогена, усиливая синтез ДНК и стимулируя пролиферативные процессы. В настоящее время миноксидил рассматривают в качестве препарата как для местной, так и для системной терапии АГА. Особый интерес вызывают методы лечения миноксидилом в комбинациях с финастеридом, спиронолактоном, топическим третиноином, а также c плазмой, обогащенной тромбоцитами, низкоинтенсивной лазерной терапией и микронидлингом, что значительно расширяет возможности лечения пациентов с АГА.

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