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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">691274</article-id><article-id pub-id-type="doi">10.18565/pharmateca.2025.5.147-151</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Clinical case</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинический разбор</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Clinical case: comparative results of using high-intensity focused electromagnetic stimulation with monopolar radio-wave lifting as monotherapy and in a combined protocol with botulinum toxin</article-title><trans-title-group xml:lang="ru"><trans-title>Клинический случай: сравнительные результаты применения электрического тока высокого напряжения с монополярным радиоволновым лифтингом в качестве монотерапии и в сочетанном протоколе с ботулиническим токсином</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7029-6597</contrib-id><name-alternatives><name xml:lang="en"><surname>Sokolova</surname><given-names>Anna V.</given-names></name><name xml:lang="ru"><surname>Соколова</surname><given-names>Анна Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Professor, Department of Dermatovenereology and Cosmetology</p></bio><bio xml:lang="ru"><p>д.м.н., профессор кафедры дерматовенерологии и косметологии</p></bio><email>tanya.masiyanskaya@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2092-1769</contrib-id><name-alternatives><name xml:lang="en"><surname>Ilyina</surname><given-names>Tatyana D.</given-names></name><name xml:lang="ru"><surname>Ильина</surname><given-names>Татьяна Дмитриевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dermatovenereologist, Cosmetologist</p></bio><bio xml:lang="ru"><p>врач-дерматовенеролог, косметолог</p></bio><email>tanya.masiyanskaya@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2820-3729</contrib-id><name-alternatives><name xml:lang="en"><surname>Chebotareva</surname><given-names>Yulia Yu.</given-names></name><name xml:lang="ru"><surname>Чеботарева</surname><given-names>Юлия Юрьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Chief Physician, Dermatovenereologist, Cosmetologist</p></bio><bio xml:lang="ru"><p>главный врач, врач-дерматовенеролог, косметолог</p></bio><email>tanya.masiyanskaya@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Medical Academy of Continuous Professional Education</institution></aff><aff><institution xml:lang="ru">Российская медицинская академия непрерывного профессионального образования</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Estelab Clinic of Aesthetic Medicine</institution></aff><aff><institution xml:lang="ru">Клиника эстетической медицины «Эстелаб»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-09-24" publication-format="electronic"><day>24</day><month>09</month><year>2025</year></pub-date><volume>32</volume><issue>5</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>147</fpage><lpage>151</lpage><history><date date-type="received" iso-8601-date="2025-09-24"><day>24</day><month>09</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-09-24"><day>24</day><month>09</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, ООО «Бионика Медиа»</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/691274">https://journals.eco-vector.com/2073-4034/article/view/691274</self-uri><abstract xml:lang="en"><p>Facial aging is a complex process that results from changes in several layers: skin, subcutaneous fat, superficial muscular aponeurotic system (SMAS), muscles and bone. Facial muscles tend to lose their tone at rest, which leads to a change in the position of tissues. This article presents clinical cases of successful use of a new device that combines the technologies of high-intensity focused electromagnetic stimulation (HIFES) and monopolar radio-wave lifting (RF) to improve skin elasticity and muscle tone, used as monotherapy (HIFES + RF) and as a complex effect (HIFES + RF and botulinum therapy); their safety, effectiveness and patient satisfaction are assessed.</p> <p>The protocol in the form of a complex effect of HIFES, monopolar radio-wave lifting and botulinum toxin type A shows the highest results in comparison with a monoprocedure, and also allows for personalized cosmetology correction of involutional atrophy of the skin of the lower third of the face and neck.</p></abstract><trans-abstract xml:lang="ru"><p>Старение лица – это сложный процесс, который является результатом изменений в нескольких слоях: кожи, подкожного жира, поверхностной мышечной апоневротической системы (SMAS), мышцах и кости. Лицевые мышцы, как правило, теряют свой тонус в покое, что приводит к изменению положения тканей. В данной статье представлены клинические случаи успешного применения нового устройства, сочетающее в себе технологии одномоментного использования электрического тока высокого напряжения (HIFES) и монополярного радиоволнового лифтинга (RF) для улучшения эластичности кожи и мышечного тонуса, применяемых в качестве монотерапии (HIFES+RF) и в виде комплексного воздействия (HIFES+RF и ботулинотерапии), оценивается их безопасность, эффективность и удовлетворенность пациентов.</p> <p>Протокол в виде комплексного воздействия HIFES, монополярного радиоволнового лифтинга и ботулинического токсина типа А показывает наиболее высокие результаты в сравнении с монопроцедурой, а также позволяет персонализированно проводить косметологическую коррекцию инволюционной атрофии кожи нижней трети лица и шеи.</p></trans-abstract><kwd-group xml:lang="en"><kwd>high-voltage electric current</kwd><kwd>radiofrequency lifting</kwd><kwd>botulinum therapy</kwd><kwd>facial aging</kwd><kwd>involutional atrophy of the facial skin</kwd><kwd>clinical case</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>электрический ток высокого напряжения</kwd><kwd>радиочастотный лифтинг</kwd><kwd>ботулинотерапия</kwd><kwd>старение лица</kwd><kwd>инфолюционная атрофия кожи лица</kwd><kwd>клинический случай</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Goldberg D.J., Lal K. 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