PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media69388410.18565/pharmateca.2025.7.76-82ReviewsОбзорыReview ArticleThe role of intestinal microbiota in the development of atopic dermatitisРоль кишечной микробиоты в развитии атопического дерматитаhttps://orcid.org/0009-0008-6981-464X1026-7270SysoevaA. S.СысоеваА. С.
Russian Federation

Assistant; Department of Medical Microbiology and Laboratory Medicine

ассистент кафедры медицинской микробиологии и лабораторной медицины

sysojchik@yandex.ruhttps://orcid.org/0000-0002-3902-2018OrlovaE. A.ОрловаЕ. А.
Russian Federation

Department of Allergology and Immunology with a Course in Dermatovenereology and Cosmetology

кафедра аллергологии иммунологии с курсом дерматовенерологии и косметологии

sysojchik@yandex.ruhttps://orcid.org/0000-0002-8440-6598LevashovaO. A.ЛевашоваО. А.
Russian Federation

Department of Medical Microbiology and Laboratory Medicine

кафедра медицинской микробиологии и лабораторной медицины

sysojchik@yandex.ruhttps://orcid.org/0009-0004-2452-747XKulievaOksana A.КулиеваО. А.
Russian Federation

Assistant; Department of Medical Microbiology and Laboratory Medicine

ассистент кафедры медицинской микробиологии и лабораторной медицины

golikowa.oksana@yandex.ruhttps://orcid.org/0000-0002-5537-5729KandrashkinaYu. A.КандрашкинаЮ. А.
Russian Federation
sysojchik@yandex.ruPenza Institute for Advanced Medical Training – Branch of the Russian Medical Academy of Continuous Professional EducationПензенский институт усовершенствования врачей – филиал ФГБОУ ДПО РМАНПО Минздрава РоссииPenza State UniversityПензенский государственный университет0711202532776821910202519102025Copyright ©; 2025, Bionika MediaCopyright ©; 2025, ООО «Бионика Медиа»2025Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/693884

Intestinal microbiota plays a significant role in the development of the immune system and has a protective effect in the formation of atopy. Recently; there has been a growing interest in studying the role of intestinal microbiota in the pathogenesis of atopic dermatitis (AD). The review discusses the mechanisms of influence of the intestinal microbiome on the development and course of AD. Patients with AD have intestinal dysbiosis; characterized by a deficiency of lactobacilli; bifidobacteria and excessive growth of pathogenic and opportunistic microorganisms. Prospects for correction of the intestinal microbiome for the treatment of AD are presented.

Микробиота кишечника играет существенную роль в становлении иммунной системы и обладает протективным действием в формировании атопии. В последнее время растет интерес к изучению роли микробиоты кишечника в патогенезе атопического дерматита (АтД). В обзоре рассматриваются механизмы влияния микробиома кишечника на развитие и течение АтД. У больных АтД отмечается дисбиоз кишечника; характеризующийся дефицитом лактобактерий; бифидобактерий и избыточным ростом патогенных и условно-патогенных микроорганизмов. Представлены перспективы коррекции микробиома кишечника для лечения АтД.

atopic dermatitisintestinal microbiotamicrobiomeprobioticsатопический дерматитмикробиота кишечникамикробиомпробиотикиSchlaeppi K.; Bulgarelli D. The plant microbiome at work. Mol Plant Microbe Interact. 2015;28(3):212–7. https://dx.doi.org/10.1094/MPMI-10-14-0334-FIIngman W.V. The Gut Microbiome: A New Player in Breast Cancer Metastasis. Cancer Res. 2019;79(14):3539–41. https://dx.doi.org/10.1158/0008-5472Ryguła I.; Pikiewicz W.; Grabarek B.O.; et al. The Role of the Gut Microbiome and Microbial Dysbiosis in Common Skin Diseases. Int J Mol Sci. 2024;25(4):1984. https://dx.doi.org/10.3390/ijms25041984O’Neill C.A.; Monteleone G.; McLaughlin J.T.; Paus R. The gut-skin axis in health and disease: A paradigm with therapeutic implications. Bioessays. 2016;38(11):1167–76. https://dx.doi.org/10.1002/bies.201600008Langan S.M.; Irvine A.D.; Weidinger S. Atopic dermatitis. Lancet. 2020;396(10247):345–60. https://dx.doi.org/10.1016/S0140-6736(20)31286-1Крысанов И.С.; Крысанова В.С.; Карпов О.И. и др. Экономическое бремя тяжелого атопического дерматита в Российской Федерации. Качественная клиническая практика. 2019;(4):4–14. [Krysanov I.S.; Krysanova V.S.; Karpov O.I.; et al. Social-economic burden of severe atopic dermatitis in the Russian Federation. Good Clin. Pract. 2019;(4):4–14. (In Russ.)].Choo Z.Y.; Mehlis S.L.; Joyce J.C. Updates in atopic dermatitis for the primary care physician: A review of advances in the understanding and treatment of atopic dermatitis. Dis Mon 2024;70(4):101687. https://dx.doi.org/10.1016/j.disamonth.2024.101687Marras L.; Caputo M.; Bisicchia S.; et al. The Role of Bifidobacteria in Predictive and Preventive Medicine: A Focus on Eczema and Hypercholesterolemia. Microorganisms. 2021;9(4):836. https://dx.doi.org/10.3390/microorganisms9040836Pantazi A.C.; Nori W.; Kassim M.A.K.; et al. Gut microbiota profile and atopic dermatitis in the first year of life. J Med Life. 2024;17(10):948–52. https://dx.doi.org/10.25122/jml-2024-0287Reddel S.; Del Chierico F.; Quagliariello A.; et al. Gut microbiota profile in children affected by atopic dermatitis and evaluation of intestinal persistence of a probiotic mixture. Sci Rep. 2019;9(1):4996. https://dx.doi.org/10.1038/s41598-019-41149-6Wrześniewska M.; Wołoszczak J.; Świrkosz G.; et al. The Role of the Microbiota in the Pathogenesis and Treatment of Atopic Dermatitis-A Literature Review. Int J Mol Sci. 2024;25(12):6539. https://dx.doi.org/10.3390/ijms25126539.Chiu C.Y.; Liao S.L.; Su K.W.; et al. Exclusive or Partial Breastfeeding for 6 Months Is Associated With Reduced Milk Sensitization and Risk of Eczema in Early Childhood: The PATCH Birth Cohort Study. Medicine. 2016;95:e3391. https://dx.doi.org/10.1097/MD.0000000000003391Fang Z.; Li L.; Zhang H.; et al. Gut Microbiota; Probiotics; and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review. Front Immunol. 2021;12:720393. https://dx.doi.org/10.3389/fimmu.2021.720393Листопадова А.П.; Кастрикина А.А.; Корнева А.А. и др. Особенности микробиома у детей с атопическим дерматитом в разные возрастные периоды. Медицина: теория и практика. 2023;8(1):47–53. [Listopadova A.P.; Kastrikina A.M.; Korneva A.A.; et al. Microbiome features in children with atopic dermatitis in different age periods. Medicine: Theor. Pract. 2023;8(1):47–53. (In Russ.)]. https://dx.doi.org/10.56871/MTP.2023.59.10.006Cait A.; Cardenas E.; Dimitriu P.A.; et al. Reduced genetic potential for butyrate fermentation in the gut microbiome of infants who develop allergic sensitization. J Allergy Clin Immunol. 2019;144(6):1638–47.e3. https://dx.doi.org/10.1016/j.jaci.2019.06.029Szöllősi A.G.; Gueniche A.; Jammayrac O.; et al. Bifidobacterium longum extract exerts pro-differentiating effects on human epidermal keratinocytes; in vitro. Exp Dermatol. 2017;26(1):92–4. https://dx.doi.org/10.1111/exd.13130Kim J.H.; Lee S.H.; Kang M.J.; et al. Host-microbial interactions between PTGR2 and Bifidobacterium in the early life gut of atopic dermatitis children. Pediatr Allergy Immunol. 2022;33(2):e13724. https://dx.doi.org/10.1111/pai.13724Fujimura K.E.; Sitarik A.R.; Havstad S.; et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat Med. 2016;22(10):1187–91. https://dx.doi.org/10.1038/nm.4176Fieten K.B.; Totté J.E.E.; Levin E.; et al. Fecal Microbiome and Food Allergy in Pediatric Atopic Dermatitis: A Cross-Sectional Pilot Study. Int. Arch. Allergy Immunol. 2018;175(1-2):77–84. https://dx.doi.org/10.1159/000484897Polkowska-Pruszyńska B.; Gerkowicz A.; Krasowska D. The gut microbiome alterations in allergic and inflammatory skin diseases – an update. J Eur Acad Dermatol Venereol. 2020;34(3):455–64. https://dx.doi.org/10.1111/jdv.15951Sung M.; Choi Y.; Park H.; Huh CS. Gut Microbiome Characteristics in Mothers and Infants According to the Presence of Atopic Dermatitis. Biomed Res Int. 2022;2022:8145462. https://dx.doi.org/10.1155/2022/8145462Fan X.; Zang T.; Dai J.; et al. The associations of maternal and children’s gut microbiota with the development of atopic dermatitis for children aged 2 years. Front Immunol. 2022;13:1038876. https://dx.doi.org/10.3389/fimmu.2022.1038876Corbin K.D.; Carnero E.A.; Dirks B.; et al. Reprogrammingthe Human Gut Microbiome Reduces Dietary Energy Harvest. Res Sq [Preprint]. 2023;25:rs.3.rs-2382790. https://dx.doi.org/10.21203/rs.3.rs-2382790/v1Alam M.J.; Xie L.; Yap Y.A.; et al. Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies. Pathogens. 2022;11(6):642. https://dx.doi.org/10.3390/pathogens11060642.Bemark M.; Pitcher M.J.; Dionisi C.; Spencer J. Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity. Trends Immunol. 2024;45(3):211–23. https://dx.doi.org/10.1016/j.it.2024.01.006Bashir H.; Singh S.; Singh R.P.; et al. Age-mediated gut microbiota dysbiosis promotes the loss of dendritic cells tolerance. Aging Cell. 2023;22(6):e13838. https://dx.doi.org/10.1111/acel.13838Akagbosu B.; Tayyebi Z.; Shibu G.; et al. Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota. Nature. 2022;610(7933):752–60. https://dx.doi.org/10.1038/s41586-022-05309-5.Moniaga C.S.; Tominaga M.; Takamori K. An Altered Skin and Gut Microbiota Are Involved in the Modulation of Itch in Atopic Dermatitis. Cells. 2022;11(23):3930. https://dx.doi.org/10.3390/cells11233930Viljanen M.; Pohjavuori E.; Haahtela T.; et al. Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema-dermatitis syndrome. J Allergy Clin Immunol. 2005;115(6):1254–9. https://dx.doi.org/10.1016/j.jaci.2005.03.047Díaz-Garrido N.; Badia J.; Baldomà L. Microbiota-derived extracellular vesicles in interkingdom communication in the gut. J Extracell Vesicles. 2021;10(13):e12161. https://dx.doi.org/10.1002/jev2.12161Жестков А.В.; Побежимова О.О. Влияние состава микробиоты кишечника на иммунопатогенез атопического дерматита у детей. Аллергология и иммунология в педиатрии. 2021;4:4–11. [Zhestkov A.V.; Pobezhimova O.O. Influence of intestinal microbiota on the immunopathogenesis of atopic dermatitis in children. Allergol Immunol Pediatr. 2021;(4):4–11. (In Russ.)]. https://dx.doi.org/10.53529/2500-1175-2021-4-4-11Ramos Meyers G.; Samouda H.; Bohn T. Short Chain Fatty Acid Metabolism in Relation to Gut Microbiota and Genetic Variability. Nutrients. 2022;14(24):5361. https://dx.doi.org/10.3390/nu14245361Kimura I.; Ichimura A.; Ohue-Kitano R.; Igarashi M. Free Fatty Acid Receptors in Health and Disease. Physiol Rev. 2020;100(1):171–210. https://dx.doi.org/10.1152/physrev.00041.2018Sanchez H.N.; Moroney J.B.; Gan H.; et al. B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids. Nat Commun. 2020;11(1):60. https://dx.doi.org/10.1038/s41467-019-13603-6Ahn J.; Lee S.; Kim B.; et al. Ruminococcus gnavus ameliorates atopic dermatitis by enhancing Treg cell and metabolites in BALB/c mice. Pediatr Allergy Immunol. 2022;33:e13678. https://doi.org/10.1111/pai.13678Yang W.; Yu T.; Huang X.; et al. Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity. Nat Commun. 2020;11(1):4457. https://dx.doi.org/10.1038/s41467-020-18262-6Pérez-Reytor D.; Puebla C.; Karahanian E.; García K. Use of Short-Chain Fatty Acids for the Recovery of the Intestinal Epithelial Barrier Affected by Bacterial Toxins. Front Physiol. 2021;12:650313. https://dx.doi.org/10.3389/fphys.2021.650313Liu Y.; Du X.; Zhai S.; et al. Gut microbiota and atopic dermatitis in children: a scoping review. BMC Pediatr. 2022;22(1):323. https://dx.doi.org/10.1186/s12887-022-03390-3Stec A.; Sikora M.; Maciejewska M.; et al. Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases. Int J Mol Sci. 2023;24(4):3494. https://dx.doi.org/10.3390/ijms24043494Su X.; Gao Y.; Yang R. Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis. Cells. 2022;11(15):2296. https://dx.doi.org/10.3390/cells11152296Yang L.; Li D.; Sun S.; et al. Dupilumab therapy improves gut microbiome dysbiosis and tryptophan metabolism in Chinese patients with atopic dermatitis. Int Immunopharmacol. 2024;131:111867. https://dx.doi.org/10.1016/j.intimp.2024.111867Park O.J.; Kwon Y.; Park C.; et al. Streptococcus gordonii: Pathogenesis and Host Response to Its Cell Wall Components. Microorganisms. 2020;8(12):1852. https://dx.doi.org/10.3390/microorganisms8121852Мухачева Д.А.; Разнатовский К.И.; Соболев А.В. Роль нейротрансмиттеров и микробиоты кишечника в патогенезе атопического дерматита. Клин. дерматология и венерология. 2023;22(3):302308. [Mukhacheva D.A.; Raznatovsky K.I.; Sobolev A.V. Role of neurotransmitters and intestinal microbiota in pathogenesis of atopic dermatitis. Clin Dermatol Venereol. 2023;22(3):302308 (In Russ.)]. https://dx.doi.org/10.17116/klinderma202322031302Kobayashi Y.; Kuhara T.; Oki M.; Xiao JZ. Effects of Bifidobacterium breve A1 on the cognitive function of older adults with memory complaints: a randomised; double-blind; placebo-controlled trial. Benef Microbes. 2019;10(5):511–20. https://dx.doi.org/10.3920/BM2018.0170Zaidi A.Z.; Moore S.E.; Okala S.G. Impact of Maternal Nutritional Supplementation during Pregnancy and Lactation on the Infant Gut or Breastmilk Microbiota: A Systematic Review. Nutrients. 2021;13(4):1137. https://dx.doi.org/10.3390/nu13041137Makrgeorgou A.; Leonardi-Bee J.; Bath-Hextall F.J. Probiotics for treating eczema. Cochrane Database Syst Rev. 2018;11(11):CD006135. https://dx.doi.org/10.1002/14651858.CD006135.pub3.Жукова О.В.; Касихина Е.И.; Острецова М.Н.; Немер А. Бактериофаги в терапии и профилактике атопического дерматита и дерматозов; осложненных вторичной бактериальной инфекцией. Мед. совет. 2022;(13):66–72. [Listopadova A.P.; Kastrikina A.M.; Korneva A.A.; et al. Microbiome features in children with atopic dermatitis in different age periods. Medicine: Theor. Pract. 2023;8(1):47–53. (In Russ.)]. https://dx.doi.org/10.21518/2079-701X-2022-16-13-66-72Гладков С.Ф.; Перевощикова Н.К. Возможности и потенциал бактериофагов в лечении атопического дерматита у детей. РМЖ. 2023;2:62–6. [Gladkov S.F.; Perevoshchikova N.K. Possibilities and potential of bacteriophages in the treatment of atopic dermatitis in children. RMJ. 2023;2:63–6. (In Russ.)].Гладков С.Ф.; Перевощикова Н.К.; Пичугина Ю.С. Опыт применения фаговой монотерапии в отношении пациента с атопическим дерматитом: клинический случай. Фарматека. 2022;29(14):116–9. [Gladkov S.F.; Perevoshchikova N.K.; Pichugina Y.S. Experience with phage monotherapy in a patient with atopic dermatitis: a clinical case. Farmateka. 2022;29(14):116–9. (In Russ.)]. https://dx.doi.org/10.18565/pharmateca.2022.14.116-119