<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "https://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">717306</article-id><article-id pub-id-type="doi">10.18565/pharmateca.2026.4.138-144</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Obstetrics/gynecology</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Акушерство/гинекология</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Iron deficiency therapy in aesthetic gynecology: current paradigms</article-title><trans-title-group xml:lang="ru"><trans-title>Терапия железодефицитных состояний в эстетической гинекологии: современные парадигмы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4581-6295</contrib-id><name-alternatives><name xml:lang="en"><surname>Apolikhina</surname><given-names>Inna A.</given-names></name><name xml:lang="ru"><surname>Аполихина</surname><given-names>Инна Анатольевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Professor, Head of the Department of Aesthetic Gynecology and Rehabilitation, Professor, Department of Obstetrics, Gynecology, Perinatology, and Reproductive Medicine, Institute of Postgraduate Education</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, зав. отделением эстетической гинекологии и реабилитации, профессор кафедры акушерства, гинекологии, перинатологии и репродуктологии ИПО</p></bio><email>efendievaz@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2978-043X</contrib-id><name-alternatives><name xml:lang="en"><surname>Efendieva</surname><given-names>Zulfiya N.</given-names></name><name xml:lang="ru"><surname>Эфендиева</surname><given-names>Зульфия Нурудиновна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.), Obstetrician-Gynecologist</p></bio><bio xml:lang="ru"><p>к.м.н., врач-акушер-гинеколог</p></bio><email>efendievaz@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Serov</surname><given-names>Vladimir N.</given-names></name><name xml:lang="ru"><surname>Серов</surname><given-names>Владимир Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, President of the Russian Society of Obstetricians and Gynecologists</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, академик РАН, Президент Российского общества акушеров-гинекологов</p></bio><email>efendievaz@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology</institution></aff><aff><institution xml:lang="ru">Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет)</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">MOSITALMED International Medical Center</institution></aff><aff><institution xml:lang="ru">Международный медицинский центр МОСИТАЛМЕД</institution></aff></aff-alternatives><content-language>ru</content-language><pub-date date-type="pub" publication-format="electronic" iso-8601-date="2026-08-17"><day>17</day><month>08</month><year>2026</year></pub-date><pub-date date-type="collection"><year>2026</year></pub-date><volume>33</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>138</fpage><lpage>144</lpage><history><date date-type="received" iso-8601-date="2026-08-17"><day>17</day><month>08</month><year>2026</year></date><date date-type="accepted" iso-8601-date="2026-08-17"><day>17</day><month>08</month><year>2026</year></date></history><pub-history><event event-type="received"><event-desc>Received:<date date-type="received" iso-8601-date="2026-08-17"><day>17</day><month>08</month><year>2026</year></date></event-desc></event><event event-type="accepted"><event-desc>Accepted:<date date-type="accepted" iso-8601-date="2026-08-17"><day>17</day><month>08</month><year>2026</year></date></event-desc></event><event event-type="pub"><event-desc>Published:<pub-date date-type="pub" publication-format="electronic" iso-8601-date="2026-08-17"><day>17</day><month>08</month><year>2026</year></pub-date></event-desc></event></pub-history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, ООО «Бионика Медиа»</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://journals.eco-vector.com/2073-4034/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/717306">https://journals.eco-vector.com/2073-4034/article/view/717306</self-uri><abstract xml:lang="en"><p>Iron deficiency conditions are particularly significant in obstetrician-gynecologist practice, as they are most common among women of reproductive age with normal menstrual cycles, pregnant women, and women in the perimenopausal period. This article presents an analysis of data from the international literature on the role of iron deficiency and the possibilities for its correction in gynecological practice. Oral iron supplements are currently the first-line treatment for anemia. Today, the rationale for prescribing iron supplements to women with anemia is unquestionable, and the wide range of medications available requires physicians to carefully select the right one, taking into account their efficacy and safety. Research results show that iron protein succinylate is equally effective as iron salts in the treatment of iron deficiency anemia, while oral administration of iron protein succinylate does not result in hepcidin blockade or the development of gastrointestinal adverse effects. Prescribing oral iron supplements at optimal, low therapeutic doses helps minimize side effects and increases iron bioavailability, maintaining high efficacy and patient compliance.</p></abstract><trans-abstract xml:lang="ru"><p>Железодефицитные состояния особенно значимы в практике акушера-гинеколога, так как наиболее часто встречаются среди женщин репродуктивного возраста с сохраненным менструальным циклом, у беременных и у женщин в перименопаузальном периоде. В данной статье представлен анализ данных, приведенных в мировой литературе, относительно роли дефицита железа и возможностей его коррекции в гинекологической практике. Первой линией лечения анемии на сегодняшний день является назначение пероральных препаратов железа. На сегодняшний день обоснованность назначения препаратов железа у женщин с анемией не вызывает сомнений, а большой выбор препаратов требует от врача грамотного подбора с учетом их эффективности и безопасности. Результаты исследований показывают, что железа протеин сукцинилат наравне с солями железа сопоставимо эффективен при лечении железодефицитной анемии, при этом пероральный прием железа протеин сукцинилата не приводит к гепсидиновой блокаде и развитию нежелательных явлений со стороны желудочно-кишечного тракта. Назначение пероральных препаратов железа в оптимальных низких терапевтических дозах способствует минимизации побочных эффектов и при этом повышает биодоступность железа, сохраняя высокую эффективность и приверженность пациентов к лечению.</p></trans-abstract><kwd-group xml:lang="en"><kwd>anemia</kwd><kwd>iron deficiency</kwd><kwd>aesthetic gynecology</kwd><kwd>hepcidin</kwd><kwd>iron supplements</kwd><kwd>iron protein succinylate</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>анемия</kwd><kwd>дефицит железа</kwd><kwd>эстетическая гинекология</kwd><kwd>гепсидин</kwd><kwd>препараты железа</kwd><kwd>железа протеин сукцинилат</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Pantopoulos K. Oral iron supplementation: new formulations, old questions. Haematologica. 2024 Sep 1;109(9):2790-2801. https://doi.org/10.3324/haematol.2024.284967</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Виноградова М.А., Серебрийская Д.С. Железодефицитные состояния в гинекологии: эффективная коррекция периоперационной анемии. Медицинский совет. 2024;18(17):66-72. [Vinogradova M.A., Serebriyskaya D.S. Iron deficiency states in gynecology: effective correction of perioperative anemia. Medical Council. 2024;18(17):66-72. (In Russ.)]. https://doi.org/10.21518/ms2024-470</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Low M.S., Speedy J., Styles C.E., et al. Daily iron supplementation for improving anaemia, iron status and health in menstruating women. Cochrane Database Syst Rev. 2016 Apr 18;4(4):CD009747. https://doi.org/10.1002/14651858.CD009747.pub2</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Choi M.S., Seiger E.R., Murray-Kolb L.E. Cognitive Function in Peri- and Postmenopausal Women: Implications for Considering Iron Supplementation. Nutrients. 2025 May 23;17(11):1762. https://doi.org/10.3390/nu17111762</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Cappellini M.D., Santini V., Braxs C., Shander A. Iron metabolism and iron deficiency anemia in women. Fertil Steril. 2022 Oct;118(4):607-614. https://doi.org/10.1016/j.fertnstert.2022.08.014</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Nikzad Z., Iravani M., Abedi P., et al. The relationship between iron deficiency anemia and sexual function and satisfaction among reproductive-aged Iranian women. PLoS One. 2018 Dec 6;13(12):e0208485. https://doi.org/10.1371/journal.pone.0208485</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Giuliano A.F.M., De Matteis C., Cantatore S., et al. Reduced serum iron levels are associated with metabolic dysfunction and sex-specific characteristics. Intern Emerg Med. 2026 Jan;21(1):129-139. https://doi.org/10.1007/s11739-025-04169-x</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Grewal M., Rehan M., Davalath D., et al. Iron Deficiency as an Underrecognized Cause of Dyspareunia and Vulvar Bleeding. Cureus. 2025 Oct 15;17(10):e94659. https://doi.org/10.7759/cureus.94659</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Vaucher P., Druais P.L., Waldvogel S., Favrat B. Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trial. CMAJ. 2012 Aug 7;184(11):1247-54. https://doi.org/10.1503/cmaj.110950</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Serati M., Espuña-Pons M., Mouton-Puglisi A., Padoa A. Iron deficiency and sexual dysfunction in women. Sex Med Rev. 2023 Sep 27;11(4):342-348. https://doi.org/10.1093/sxmrev/qead028</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Urman B., Boza A., Balaban B. Platelet-rich plasma another add-on treatment getting out of hand? How can clinicians preserve the best interest of their patients? Hum Reprod. 2019 Nov 1;34(11):2099-2103. https://doi.org/10.1093/humrep/dez190</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Parikh S., Bentz T., Crowley S., et al. Perioperative Blood Management. J Clin Med. 2025;14:3847. https://doi.org/10.3390/jcm14113847</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Guideline for the Management of Anaemia in the perioperative pathway 2022 Centre for Perioperative care (CPOC).</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>National Institute for Health and Care Excellence (NICE). Blood transfusion. Quality standard. Published: 15 December 2016. nice.org.uk/guidance/qs138</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Muñoz M., Acheson A.G., Bisbe E., et al. An international consensus statement on the management of postoperative anaemia after major surgical procedures. Anaesthesia. 2018 Nov;73(11):1418-1431. https://doi.org/10.1111/anae.14358</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Lawton S. Skin changes associated with ageing. Br J Community Nurs. 2023 Oct 2;28(10):504-508. https://doi.org/10.12968/bjcn.2023.28.10.504</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Stangl S., Popp M., Reis S., et al. Reported outcomes in patients with iron deficiency or iron deficiency anemia undergoing major surgery: a systematic review of outcomes. Syst Rev. 2024;13:5. https://doi.org/10.1186/s13643-023-02431-x</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Wright J.A., Richards T., Srai S.K. The role of iron in the skin and cutaneous wound healing. Front Pharmacol. 2014 Jul 10;5:156. https://doi.org/10.3389/fphar.2014.00156</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Von Holle A., Ramamurthy S., Díaz Santana M.V., et al. Association Between Body Iron Status and Biological Aging. Nutrients. 2025 Apr 23;17(9):1409. https://doi.org/10.3390/nu17091409</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Wacka E., Nicikowski J., Jarmuzek P., Zembron-Lacny A. Anemia and Its Connections to Inflammation in Older Adults: A Review. J Clin Med. 2024 Apr 2;13(7):2049. https://doi.org/10.3390/jcm13072049</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Tear A.A., Tesno F.A., Shofiadeita H., et al. Association between anaemia and osteoporosis: a systematic review and meta-analysis. Ann Med. 2026 Dec;58(1):2610878. https://doi.org/10.1080/07853890.2025.2610878</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Ubom A.E., Begum F., Ramasauskaite D., et al. FIGO good practice recommendations on anemia in pregnancy, to reduce the incidence and impact of postpartum hemorrhage (PPH). Int J Gynecol Obstet. 2025;171:993-1007. https://doi.org/10.1002/ijgo.70529</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Jessian L. Muñoz, Oluwatosin Goje. Anemia in Pregnancy. MSD Manual. Jul 2024 Modified Sept 2025.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>De Franceschi L., Iolascon A., Taher A., Cappellini M.D. Clinical management of iron deficiency anemia in adults: Systemic review on advances in diagnosis and treatment. Eur J Intern Med. 2017 Jul;42:16-23. https://doi.org/doi: 10.1016/j.ejim.2017.04.018</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Pavord S., et al. UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol. 2020 Mar;188(6):819-830. https://doi.org/10.1111/bjh.16221</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Celis A.I., Relman D.A., Huang K.C. The impact of iron and heme availability on the healthy human gut microbiome in vivo and in vitro. Cell Chem Biol. 2023 Jan 19;30(1):110-126.e3. https://doi.org/10.1016/j.chembiol.2022.12.001</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Dentand A.L., Schubert M.G., Krayenbuehl P.A. Current iron therapy in the light of regulation, intestinal microbiome, and toxicity: are we prescribing too much iron? Crit Rev Clin Lab Sci. 2024 Nov;61(7):546-558. https://doi.org/10.1080/10408363.2024.2331477</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA). Scientific opinion on the tolerable upper intake level for iron. EFSA Journal 2024.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Urso K., Leal Martínez-Bujanda J., del Prado, J.M. Iron Protein Succinylate in the Management of Iron Deficiency Anemia: A Comparative Study with Ferrous Sulphate at Low and High Therapeutic Doses. Nutrients 2021;13:968. https://doi.org/10.3390/nu13030968</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Izquierdo L. Efficacy and Tolerability of Oral Iron Protein Succinylate in the Treatment of Iron Deficiency Anemia in Adults with Gastrointestinal Diseases. International Journal of Gastroenterology. 2021;5(2):40-47. https://doi.org/10.11648/j.ijg.20210502.11</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Córdova A., Mielgo-Ayuso J., Fernandez-Lazaro C.I., et al. Effect of Iron Supplementation on the Modulation of Iron Metabolism, Muscle Damage Biomarkers and Cortisol in Professional Cyclists. Nutrients. 2019 Feb 27;11(3):500. https://doi.org/10.3390/nu11030500</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Martínez Francés, A., &amp; Leal Martínez-Bujanda, J. Efficacy and tolerability of oral iron protein succinylate: a systematic review of three decades of research. Curr Med Res Opin. 2020;36(4):613–623. https://doi.org/10.1080/03007995.2020.1716702</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Михайлова О.И., Мирзабекова Д.Д., Тютюнник В.Л., Кан Н.Е. Терапия железодефицитной анемии в послеродовом периоде. Фармакология &amp; Фармакотерапия. 2022;(3):60-3. [Mikhailova O.I., Mirzabekova D.D., Tyutyunnik V.L., Kan N.E. Treatment of iron deficiency anemia in the postpartum period. Pharmacology &amp; Pharmacotherapy. 2022;(3):60-3. (In Russ.)]. https://dx.doi.org/10.46393/27132129_2022_3_60</mixed-citation></ref></ref-list></back></article>
