PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media71731510.18565/pharmateca.2026.4.210-214Obstetrics/gynecologyАкушерство/гинекологияResearch ArticleTheca-lutein cysts of the ovaries in the third trimester of pregnancy: a case reportТекалютеиновые кисты яичников в третьем триместре беременности: случай из практикиhttps://orcid.org/0009-0009-8834-3019LebedevaNatalia V.ЛебедеваНаталья Владимировна
Russian Federation

Cand. Sci. (Med.), Associate Professor, Department of Obstetrics and Gynecology, Faculty of Continuous Professional Education

к.м.н., доцент кафедры акушерства и гинекологии факультета дополнительного профессионального образования

natali.lebedeva.72@mail.ruhttps://orcid.org/0009-0002-1241-7076GusevaOlga I.ГусеваОльга Игоревна
Russian Federation

Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology, Faculty of Continuous Professional Education

д.м.н., профессор кафедры акушерства и гинекологии ФДПО

alise52@yandex.ruhttps://orcid.org/0000-0001-8850-56844490-5591MorozovaYulia V.МорозоваЮлия Валерьевна
Russian Federation

Cand. Sci. (Med.), Associate Professor, Department of Obstetrics and Gynecology

к.м.н., доцент кафедры акушерства и гинекологии

juliamorozova@list.ruKatkovaNadezhda Y.КатковаНадежда Юрьевна
Russian Federation

Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology, Faculty of Continuous Professional Education

д.м.н., профессор кафедры акушерства и гинекологии ФДПО

katkova_nu@inbox.ruPrivolzhsky Research Medical UniversityПриволжский исследовательский медицинский университетru1708202620263342102141708202617082026Received:17082026Accepted:17082026Published:17082026Copyright ©; 2026, Bionika MediaCopyright ©; 2026, ООО «Бионика Медиа»2026Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/about/editorialPolicieshttps://journals.eco-vector.com/2073-4034/article/view/717315

Hyperreactio luteinalis is a rare condition characterized by ovarian enlargement due to multiple theca-lutein cysts and likely associated with elevated human chorionic gonadotropin (hCG) levels or an abnormal ovarian response to hCG [1]. Hyperreactio luteinalis is most often seen in conditions with elevated hCG levels, such as trophoblastic disease, multiple pregnancy, or nonimmune hydrops fetalis, but can also occur in normal singleton pregnancies [2]. This article presents a clinical case of large theca-lutein cysts that developed in the third trimester of pregnancy with a favorable outcome. During follow-up until delivery at 37-38 weeks, a progressive increase in the size of the ovarian cysts was noted. A partial resection of both ovaries was performed during a cesarean section. The postoperative period was uneventful, and a follow-up ultrasound two months later revealed complete regression of the theca-lutein cysts.

Hyperreactio luteinalis – редкое состояние, характеризующееся увеличением яичников из-за множественных текалютеиновых кист и, вероятно, связанное с повышенным уровнем хорионического гонадотропина человека (ХГЧ) или аномальной реакцией яичников на ХГЧ [1]. Hyperreactio luteinalis чаще всего встречается при состояниях с повышенным уровнем ХГЧ, таких как трофобластическая болезнь, многоплодная беременность или неиммунная водянка плода, но также может возникать при нормальной одноплодной беременности [2]. В статье представлен клинический случай крупных текалютеиновых кист, развившихся в третьем триместре беременности с благоприятным исходом. При динамическом наблюдении до родоразрешения в 37–38 недель отмечалось прогрессивное увеличение размеров кист яичников. При операции кесарева сечения выполнена частичная резекция обоих яичников. Послеоперационный период протекал без осложнений и через 2 месяца на контрольном ультразвуковом исследовании обнаружен полный регресс текалютеиновых кист.

ovarian theca-lutein cystscorpus luteum hyperreactivityhuman chorionic gonadotropinтекалютеиновые кисты яичниковгиперреакция желтого телахорионический гонадотропин человекаMalinowski A.K., Sen J., Sermer M. Hyperreactio luteinalis: maternal and fetal effects. J Obstet Gynaecol Can. 2015;37(8):715–723. https://doi:10.1016/S1701-2163(15)30176-6Faden M., Salehi A.H., Simon J., et al. Hyperreactio luteinalis in association with multiple foetal malformations – a consequence of supra-physiological HCG? Case Rep Perinat Med. 2014;3:5–9. https://doi:10.1515/crpm-2013-0030Horowitz N.S. Management of adnexal masses in pregnancy. Clin Obstet Gynecol. 2011;54(4):519–527. https://doi: 10.1097/GRF.0b013e318236c583Sarmento Gonçalves I., Malafaia S., Belchior H., Tiago-Silva P. Hyperreactio luteinalis encountered during caesarean delivery of an uncomplicated spontaneous singleton pregnancy. BMJ Case Rep. 2015:2015:bcr2015211349. https://doi: 10.1136/bcr-2015-211349.Kurakula S., Muralidharan V., Chengappa Appaneravanda L., et al. Rupture of Bilateral Theca Lutein Cysts During Pregnancy: A Case Report. Cureus. 2022;14(9):e29758. https://doi: 10.7759/cureus.29758.Upadhyaya G., Goswami A., Babu S. Bilateral theca lutein cysts: a rare cause of acute abdomen in pregnancy. Emerg Med Australas. 2004;16(5-6):476–477. https://doi: 10.1111/j.1742-6723.2004.00654.xIlanchezhian S., Mohan S.V., Ramachandran R., Babu S.R. Spontaneous ovarian hyperstimulation syndrome with primary hypothyroidsm: Imaging a rare entity. Radiol Case Rep. 2015;10(1):1050. https://doi: 10.2484/rcr.v10i1.1050Panagiotopoulou N., Byers H., Newman W.G., Bhatia K. Spontaneous ovarian hyperstimulation syndrome: Case report, pathophysiological classification and diagnostic algorithm. Eur J Obstet Gynecol Reprod Biol. 2013;169(2):143–148. https://doi: 10.1016/j.ejogrb.2013.03.004De Leener A., Montanelli L., Van Durme J., et al. Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology. J Clin Endocrinol Metab. 2006;91(2):555–562. https://doi: 10.1210/jc.2005-1580Daelemans C., Smits G., de Maertelaer V., et al. Prediction of severity of symptoms in iatrogenic ovarian hyperstimulation syndrome by follicle-stimulating hormone receptor Ser680Asn polymorphism. J Clin Endocrinol Metab. 2004;89(12):6310–6315. https://doi: 10.1210/jc.2004-1044Smits G., Olatunbosun O., Delbaere A., Pierson R., et al. Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor. N Engl J Med. 2003;349(8):760–766. https://doi: 10.1056/NEJMoa030064Vasseur C., Rodien P., Beau I., et al. A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome. N Engl J Med. 2003;349(8):753–759. https://doi: 10.1056/NEJMoa030065Delbaere A., Smits G., Olatunbosun O., et al. New insights into the pathophysiology of ovarian hyperstimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome? Hum Reprod. 2004;19(3):486–489. https://doi: 10.1093/humrep/deh124Nwafor N.N., Nyoyoko N.P. Spontaneous Ovarian Hyperstimulation Syndrome: A Report of Two Cases from Different Pathogenesis. Niger Med J. 2020;61(5):269–272. https://doi: 10.4103/nmj.NMJ_183_20Lynn K.N., Steinkeler J.A., Wilkins-Haug L.E., Benson C.B. Hyperreactio luteinalis (enlarged ovaries) during the second and third trimesters of pregnancy: common clinical associations. J Ultrasound Med. 2013;32(7):1285–1289. https://doi: 10.7863/ultra.32.7.1285Ahn H. Imaging in Acute Obstetric Conditions: A Pictorial Essay. Korean J Radiol. 2025;26(7):660–677. https://doi: 10.3348/kjr.2025.0037Кириллова Е.Н, Шостак В.А., Павлюкова С.А. и др. Текалютеиновые кисты во время беременности: клинические случаи. Медицинский журнал. 2025;3:91–100. [Kirillova E.N., Shostak V.A., Pavlukova S.A., et al. Thecalutein cysts during pregnancy: Clinical cases. Medical journal. 2025;3:91–100. (In Russ.)]. https://doi.org/10.51922/1818-426X.2025.3.91