AMOXICILLIN/CLAVULANATE IN THE TREATMENT OF INFECTIONS OF RESPIRATORY SYSTEM AND ENT-ORGANS IN CHILDREN: WHAT DOSE TO CHOOSE?


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Abstract

Amoxicillin/clavulanate is widely used in clinical practice for 30 years. This drug has highly stable activity against the major bacterial pathogens of the respiratory system and ENT-organs in children: Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. Due to the high level of resistance of pneumococcus to penicillin, the use of high-dose amoxicillin (80-90 mg/kg/day) is recommended in a number of countries. Currently, amoxicillin/clavulanate at a dose of 40-45 mg/kg/day (per amoxicillin) is possible to use in Russia. Administration of amoxicillin/clavulanate with a high content of amoxicillin is reasonable only in patients with risk of infection by penicillin-resistant pneumococcus.

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