Otsenka antiishemicheskoy i kardioprotektivnoy effektivnosti aktivatora kalievykh kanalov nikorandila u patsientov so stabil'noy stenokardiey
- Authors: Rezvanova Y.A1, Adamchik A.S1
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Affiliations:
- Issue: No 13 (2015)
- Pages: 6-10
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/288100
- ID: 288100
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Abstract
The study was aimed to the analysis of the frequency of prescription of potentially not recommended drugs according to the «STOPP START» criteria for elderly patients in therapeutic departments of hospital. For 4 months, medical records of 150 patients, 47 men and 103 women aged 79.0±15.5 years, were analyzed. On average, patients have received 6.4±4.0 drugs simultaneously. Analysis of prescription leaflets has been identified 87 potentially not recommended drugs, the use of which should be avoided in older patients in certain clinical situations. The most commonly prescribed potentially not recommended drugs included nonsteroidal anti-inflammatory agents for moderate and severe arterial hypertension (16% of patients) and chronic renal insufficiency (10% of patients), and systemic corticosteroids instead of inhaled corticosteroids as maintenance therapy in patients with chronic obstructive pulmonary disease (4.66% of patients). The findings give evidence of the frequent prescription of potentially not recommended drugs for older patients in the therapeutic departments of hospital that leads to the increase of the risk of adverse drug reactions in these patients.
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References
- Gayet J.L, PaganeHi F., Cohen-Soiai A. Update on the medical treatment of stable angina. Archives Cardiovasc. Dis. 2011;104(10):536-44.
- Gomma A.H., Purceii H.J., Fox K.M. Potassium channel openers in myocardial ischaemia. Drugs. 2001;61(12):1705-10.
- IONA Study Groupl. Effect of nicorandil on coronary events in patients with stable angina: the Impact Of Nicorandil in Angina (IONA) randomised trial. Lancet. 2002;359(9314): 1269- 75.
- Izumiya Y, Kojima S., Kojima S., Araki S., Usuku H., Matsubara J., Sakamoto K., Tsujita K., Naga-yoshi Y., Kaikita K., Sugiyama S., Ogawa H. Long-term use of oral nicorandil stabilizes coronary plaque in patients with stable angina pectoris. Atherosclerosis. 2011;214(2):415-21.
- Dzemali O., Risteski P., Bakhtiary F., Singer E., Zierer A.,Kleine P., Moritz A. Surgical left ventricular remodeling leads to better long-term survival and exercise tolerance than coronary artery bypass grafting alone in patients with moderate ischemic cardiomyopathy. J. Thoracic Cardiovasc. Surg. 2009;138(3):663-68
- Li J.J., Fang C.H. C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases. Med. Hypothes. 2004;62(4):499-506.
- Kjekshus J., Apetrei E., Barrios V., Böhm M., Cleland J.G., Cornel J.H., Dunselman P., Fonseca C., Goudev A., Grande P., Gullestad L., Hjalmarson A., Hradec J., Janosi A., Kamensky G., Komajda M., Korewicki J., Kuusi T., Mach F., Mareev V., McMurray J.J., Ranjith N., Schaufelberger M., Vanhaecke J., van Veldhuisen D.J., Waagstein F., Wedel H., Wikstrand J. Rosuvastatin in older patients with systolic heart failure. N. Engl. J. Med. 2007;357(22):2248-61.
- Montalescot G., Sechtem U., Achenbach S., et al. 2013 ESC guidelines on the management of stable coronary artery disease. Europ. Heart J. 2013;34(38):2949-3003.
- Roger V.L., Go A.S., Lloyd-Jones D.M., et al. Heart disease and stroke statistics-2012 update a report from the American heart association. Circulation. 2012;125(1):e2-e220.
- Slezak J., et al. Hibernating myocardium: pathophysiology, diagnosis, and treatment this article is one of a selection of papers from the NATO Advanced Research Workshop on Translational Knowledge for Heart Health (published in part 2 of a 2-part Special Issue). Canad. J. Physiol. Pharmacol. 2009;87(4):252-65.
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