EXPRESSION OF TOLL-LIKE RECEPTORS-4 BY PERIPHERAL BLOOD CELLS IN PATIENTS WITH MYOCARDIAL INFARCTION AND ISCHEMIC STROKE


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Abstract

Experimental studies have shown that Toll-like receptors-4 (TLR4) play an important role in the pathogenesis of ischemic damage to the myocardium and brain. The blocking of tlr4 genes or the use of antibodies to these receptors can improve the outcome of acute ischemic damage and allow these receptors to be considered as a possible therapeutic target. A comparative evaluation of the activation of TLR4 expression in the pathogenesis of myocardial infarction and ischemic stroke in a clinical study seems relevant. The results of the evaluation of the levels of expression of superficial TLR4 peripheral blood cells (monocytes and granulocytes), their dynamics and clinical significance in patients with ischemic atherothrombotic stroke compared with patients with acute myocardial infarction and control group are presented. Using flow cytofluorimetry method, a significant direct correlation between the expression of TLR4 on blood mononuclear cells and the heart rate, as well as the size of the left heart and the left ventricular end-systolic dimension and left ventricular end-diastolic dimension in patients with myocardial infarction were revealed. In patients with ischemic atherothrombotic stroke, a statistically significant direct correlation of TLR4 expression on mononuclear cells on day 14 and NIHSS scores at the 1, 7 and 14 day of the disease was indentified. The results obtained confirm participation of TLR4 activation in ischemic damage to the myocardium and brain and allow considering them as a possible marker of damage severity.

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About the authors

M. Kh Shurdumova

FSBEI HE “Russian National Scientific Medical University n.a. N.I. Pirogov" of RMH

Email: dr_shurdumova@mail.ru
PhD, Associate Professor at the Department of Fundamental and Clinical Neurology and Neurosurgery MBF

E. V Konstantinova

FSBEI HE “Russian National Scientific Medical University n.a. N.I. Pirogov" of RMH

N. A Shostak

FSBEI HE “Russian National Scientific Medical University n.a. N.I. Pirogov" of RMH

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