IVF program with donor oocytes for a woman in persistent postmenopause: clinical observation


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Abstract

Background. The increase in the number of patients with infertility and the lack of ovarian reserve contributed to the development of a new trend in reproductive medicine - in vitro fertilization (IVF) with donor oocytes. Description of the clinical case. A clinical observation of a 50-year-old female patient who applied for an IVF program due to secondary infertility due to a lack of ovulation as a result of persistent physiological menopause, as well as a male factor is presented. Given the inability to obtain her own oocytes, it was decided to conduct an IVF program with donor oocytes. At the first stage, cyclic hormone therapy was prescribed to restore the menstrual cycle. After 3 months, an IVF program with donor oocytes was performed. Fertilization of 4 donor oocytes by the seminal fluid of the spouse by the PICSI method (intracytoplasmic injection of a spermatozoon selected on a physiological basis) was performed. Preparation of the endometrium in the embryo transfer cycle was carried out using estrogens and gestagens. The IVF program ended with the onset of clinical pregnancy and timely delivery. Conclusion The IVF program with donor oocytes allows for the implementation of reproductive function in various categories of patients, including with persistent menopause.

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About the authors

Ya. A Petrosyan

V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Moscow, Russia

T. R Mamedova

V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Moscow, Russia

A. G Syrkasheva

V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Email: a_syrkasheva@oparina4.ru
PhD, Senior Researcher of B.V. Leonov IVF Department of Auxiliary Technologies in Infertility Treatment 4, Akademik Oparin Street, Moscow 117997, Russian Federation

E. A Kalinina

V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

Moscow, Russia

References

  1. Denson V. Diagnosis and Management of Infertility. J Nurse Pract. 2006;2(6):380-86.
  2. Мишиева Н.Г. Бесплодие у женщин позднего репродуктивного возраста: принципы диагностики и лечения в зависимости от овариального резерва. 2008. [Mishieva N.G. Infertility in women of late reproductive age: principles of diagnosis and treatment, depending on the ovarian reserve. 2008. (In Russ.)].
  3. Боярский К.Ю., Гайдуков С.Н., Чкуасели А.С. Факторы, определяющие овариальный резерв женщины. Журнал акушерства и женских болезней. 2009;58(2):65-71.
  4. Gougeon A., Ecochard R., Thalabard J.C. Agerelated changes of the population of human ovarian follicles: increase in the disappearance rate of non-growing and early-growing follicles in aging women. Biol Reprod. 1994;50(3):653-63.
  5. Hansen K.R., Knowlton N.S., Thyer A.C., et. al. A new model of reproductive aging: The decline in ovarian non-growing follicle number from birth to menopause. Hum Reprod. 2008;23(3):699-708. doi: 10.1093/humrep/dem408.
  6. Laven J.S.E. Genetics of Early and Normal Menopause. Semin. Reprod Med. 2015;33(6):377-83. doi: 10.1055/s-0035-1567825.
  7. Pelosi E., Forabosco A., Schlessinger D. Genetics of the ovarian reserve. Front Genet. 2015;6:308. doi: 10.3389/fgene.2015.00308.
  8. Johnson N.P, Bagrie E.M., Coomarasamy A., et al. Ovarian reserve tests for predicting fertility outcomes for assisted reproductive technology: The International Systematic Collaboration of Ovarian Reserve Evaluation protocol for a systematic review of ovarian reserve test accuracy. BJOG. An Int J Obstet Gynaecol. 2006;113(12):1472-80.
  9. Velde E.R., Pearson P.L. The variability of female reproductive aging. Hum Reprod Update. 2002;8(2):141-54.
  10. Klein N., Battaglia D., Fujimoto V., et al. Reproductive aging: accelerated ovarian follicular development associated with a monotropic follicle-stimulating hormone rise in normal older women. J Clin Endocrinol Metab. 1996;(81): 1038-45.
  11. Liu K., Case A. Advanced reproductive age and fertility. J Obs Gynaecol Can. 2011;33(11):1165-75. doi: 10.1016/S1701-2163(16)35087-3.
  12. Broekmans F.J., Soules M.R., Fauser B.C. Ovarian aging: Mechanisms and clinical consequences. Endocr Rev. 2009;30(5):465-93. Doi: 10.1210/ er.2009-0006.
  13. Nesbitt-Hawes E.M., Ledger W. Endometriosis and infertility. Reprod Surg Assist. Concept. 2015;29-35.
  14. Корсак В.С., Парусов В.Н., Кирсанов А.А., Исакова Э.В. Влияние резекции яичников на их функциональный резерв. Проблемы репродукции. 1996;2(4):63-7.
  15. Nargund G., Cheng W.C., Parsons J. The impact of ovarian cystectomy on ovarian response to stimulation during in-vitro fertilization cycles. Hum Reprod. 1996;11(1):81-3.
  16. Shulman A., Marom H., Oelsner G., et al. The effect of adnexal surgery on the ovarian response to stimulation in in vitro fertilization. Eur J Obs Gynecol Reprod Biol. 2002;103(2):158-62.
  17. Белялова Н.С., Белялов Ф.И. Факторы риска и профилактика рака. Клиническая медицина. 2005;11(1):17-21.
  18. Lushbaugh C., Carasett C. The effects of gonadal irradiation in clinical radiation therapy: a review. Cancer. 1976;37:1111-20.
  19. Bokemeyer C., Schmoll H., Van Rhee J., et al. Longterm gonadal toxicity after therapy for Hodgkin' s and non-Hodgkin's lymphoma. Ann Hemat. 1994;68(3):105-10.
  20. Sharara F.I., Beatse S.N., Leonardi M.R., et al. Cigarette smoking accelerates the development of diminished ovarian reserve as evidenced by the clomiphene citrate challenge test. Fertil Steril. 1994;62(2):257-62.
  21. Sunderam S., Kissin D.M., Crawford S.B., et al. Assisted Reproductive Technology Surveillance -United States, 2014. MMWR. Surveill Summ. 2017;66(6):1-24. doi: 10.15585/mmwr. ss6606a1.
  22. Приказ Минздрава России №107н от 30 августа 2012 г [Приказ Минздрава России №107н от 30 августа 2012 г [Order of the Ministry of Health of Russia No. 107n of August 30, 2012. (In Russ.)].
  23. Care L.I., Criteria P.I. Guidelines for the provision of infertility services. Fertil Steril. 2004;82(1):24-5.
  24. Zegers-Hochschild F., Adamson G.D., de Mouzon J., et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril. 2009;92(5):1520-24. Doi: 10.1016/j. fertnstert.2009.09.009

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