Efficacy and safety of mepolizumab in patients with bronchial asthma in real clinical practice
- Authors: Nenasheva N.M1, Fedosenko S.V2,3, Barabanova E.N3
-
Affiliations:
- Russian Medical Academy of Continuous Professional Education
- Siberian State Medical University
- GlaxoSmithKline Trading JSC
- Issue: Vol 27, No 10 (2020)
- Pages: 125-132
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/312837
- DOI: https://doi.org/10.18565/pharmateca.2020.10.125-132
- ID: 312837
Cite item
Abstract
Persistent eosinophilic inflammation in the mucous membrane of the lower respiratory tract in patients with severe bronchial asthma determines their propensity for an uncontrolled course of the disease against the background of standard pharmacotherapy, and also increases the risk of an unfavorable prognosis, including more frequent and severe exacerbations, emergency care and hospitalizations, the need for high doses inhaled and systemic glucocorticosteroids. Mepolizumab is humanized monoclonal antibody that bind free interleukin-5, as a result of which a pronounced decrease in the number of eosinophils in the blood and respiratory tract is observed. In randomized clinical trials, mepolizumab significantly reduced the frequency of asthma exacerbations and related hospitalizations, reduced the dose of oral glucocorticosteroids, significantly improved the quality of life and control of clinical symptoms, and also improved respiratory function in patients with severe eosinophilic asthma. At the same time, it is difficult to generalize data from controlled studies to the patient population in real life. This review discusses the published results of a number of open-label observational studies on the efficacy and safety of mepolizumab in patients with severe asthma in real clinical practice.
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About the authors
N. M Nenasheva
Russian Medical Academy of Continuous Professional Education
Email: 1444031@gmail.com
Dr. Sci. (Med.), Prof., Head of the Department of Allergology and Immunology 2/1, build. 1, Barrikadnaya str., Moscow 125993, Russian Federation
S. V Fedosenko
Siberian State Medical University; GlaxoSmithKline Trading JSCTomsk, Russia; Moscow, Russia
E. N Barabanova
GlaxoSmithKline Trading JSCMoscow, Russia
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