Relationship of interleukin-1p gene -511c/t polymorphism with duodenal ulcer and erosive gastroduodenitis in children
- Authors: Ikhsanov S.D1, Shtepo M.N1
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Affiliations:
- Astrakhan State Medical University
- Issue: Vol 28, No 9 (2021)
- Pages: 57-61
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/313238
- DOI: https://doi.org/10.18565/pharmateca.2021.9.57-61
- ID: 313238
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Abstract
Background. Currently, the study of the genetic basis of the immune response in peptic ulcer disease in children, in particular the interleukin-1e gene polymorphisms, makes it possible to expand the etiopathogenetic understanding of the disease and identify genetic risk factors for certain complications and variants of course, which can contribute to a personalized approach to the treatment of disease. Objective. Evaluation of the effect of interleukin- (IL-1/3) gene -511c/t polymorphism on the course of duodenal ulcer (DU) and erosive gastroduodenitis (EGD) in children. Methods. A total of 100 patients with erosive and ulcerative lesions of the gastroduodenal zone (main group) including 46 children diagnosed with DU (subgroup 1) and 54 with EGD (subgroup 2) were examined. The mean age at diagnosis was 8.14±0.25 (3-17 years) years. The control group for genetic studies included 100 healthy residents of Astrakhan. For molecular genetic analysis, total DNA was isolated from whole blood using the standard phenol-chloroform extraction method. Genotyping of polymorphic markers of the studied gene was carried out using polymerase chain reaction and analysis of restriction fragment length polymorphism. Statistical analysis was performed using the Statistica for Windows software package. Results. The influence of IL-1fi-511c/t polymorphism on the features of the clinical picture and the course of EGD and DU in children was studied. It has been proven that the T/T genotype predisposes to the development of DU and is associated with the onset of the disease at an early age. Associations of the C/T genotype with the typical phenotype of diseases were revealed, while with the C/C genotype, a high significance of the hereditary factor in the development of the disease was noted. Conclusion. It was found that the studied the IL-1fi gen polymorphism is part of the genetic component of susceptibility to DU in children, and influences the age of implementation and the phenotype of the disease.
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About the authors
S. D Ikhsanov
Astrakhan State Medical UniversityAstrakhan, Russia
M. N Shtepo
Astrakhan State Medical University
Email: gazken@rambler.ru
Astrakhan, Russia
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