Consumption of oral anticoagulants in hospitals of the Russian Federation: analysis of the dynamics of procurement data
- Authors: Matveev A.V.1, Glagoleva S.V.1, Sychev D.A.1
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Affiliations:
- Medical Academy of Continuous Professional Education
- Issue: Vol 30, No 12 (2023)
- Pages: 98-106
- Section: Original articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/626057
- DOI: https://doi.org/10.18565/pharmateca.2023.12.98-106
- ID: 626057
Cite item
Abstract
Background. Thromboembolic complications are the one the factors that plays a significant role in the increase in mortality and disability of the population. The main role in their treatment and prevention belongs to anticoagulants; incl. oral anticoagulants (OACs); which include rivaroxaban; apixaban and dabigatran. OACs have gained particular importance in the context of the novel coronavirus infection (COVID-19) pandemic.
Objective. Evaluation of the consumption of OACs in hospitals in the Russian Federation for the period from 2017 to 2022 and the characteristics of their consumption during the COVID-19 pandemic.
Methods. The database of OOO Cursor Marketing LLC was used as a data source. Data on contracts concluded between 01/01/2017 and 12/31/2022 were analyzed. Data published by WHO from March 1; 2020 to December 31; 2022 were used as a source of data on morbidity and mortality from COVID-19. Consumption was calculated based on DDD (Defined Daily Dose) data presented on the WHO Collaborating Center website.
Results. Total for the period 2017–2022. 57;866 records were entered into the Cursor databases; of which 47.38% of records contained an indication that the purchased drug was rivaroxaban; 26.51% – dabigatran and 26.11% – apixaban. There was a drop in the number of contracts in 2022; from 2017 to 2021; their number grew; with the increase being more pronounced for apixaban and the least significant for dabigatran. Similar dynamics were observed for the volume of contracts; expressed in the number of packages and DDD; 97% of all contracts were concluded for a period of one year. For all analyzed time series; the presence of seasonality was found. The number of packages purchased and the DDD of rivaroxaban (P<0.05) and apixaban (P<0.001) purchased were correlated with rates of new illness and death from COVID-19.
Conclusion. The problem of studying the dynamics of OAC consumption is of significant practical interest. The number of requests for the purchase of OACs in Russian hospitals is increasing; and the COVID-19 pandemic has had a significant impact on the procurement structure.
Keywords
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About the authors
Aleksandr V. Matveev
Medical Academy of Continuous Professional Education
Author for correspondence.
Email: matveevav@rmapo.ru
ORCID iD: 0000-0002-6636-3950
SPIN-code: 8518-1320
Scopus Author ID: 37088844200
ResearcherId: 6168-2019
Cand. Sci. (Med.), Associate Professor at the Department of Clinical Pharmacology and Therapy n.a. acad. B.E. Votchaln
Russian Federation, MoscowS. V. Glagoleva
Medical Academy of Continuous Professional Education
Email: matveevav@rmapo.ru
Scopus Author ID: 57193931109
Department of Clinical Pharmacology and Therapy n.a. Acad. B.E. Votchaln
Russian Federation, Moscow
D. A. Sychev
Medical Academy of Continuous Professional Education
Email: matveevav@rmapo.ru
ORCID iD: 0000-0002-4496-3680
SPIN-code: 4525-7556
Scopus Author ID: 7801389135
ResearcherId: 6422-2018
Department of Clinical Pharmacology and Therapy n.a. Acad. B.E. Votchaln
Russian Federation, MoscowReferences
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