Effect of glucagon-like peptide-1 receptor agonist on cardiovascular risk markers in patients with type 2 diabetes mellitus


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Аннотация

The effect of the glucagon-like peptide-1 receptor agonist, exenatide, on the dynamics of cardiovascular risk markers, glucose triad indicators, lipid metabolism, body weight, waist circumference (WC) and body mass index (BMI) in patients with type 2 diabetes mellitus (DM2) was evaluated. The study included 70 patients; main group consisted of 50 patients who received exenatide for 6 months according to classic treatment regimen. Twenty patients were comparison group and received conventional glucose-lowering therapy. Prior to the beginning and at the end of the study, markers of cardiovascular risk were assessed in both groups: C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha), integrated indicator of the status of carbohydrate metabolism, glycated hemoglobin (HbA1c), lipid profile, body weight, WC, and BMI. At the end of the study, there was a significant decrease in CRP levels (p<0.001) and a trend towards reduction in TNF-α levels (p<0.1) in the exenatide group versus the comparison group. Significant reduction in low-density lipoprotein cholesterol, increase in high-density lipoprotein cholesterol levels, and reduction of atherogenic index were observed in exenatide group. Also, highly significant (compared to the comparison group) decrease in body weight, BMI, HbA1c levels and WC were noted in main group. Thus, exenatide was effective not only as prandial regulator, but also as a preparation with pleiotropic effects having beneficial influence on cardiovascular risk markers in DM2 patients, which suggests the presence of cardioprotective effect of this drug.

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Авторлар туралы

A. Mkrtumyan

FSBEI HE "MSMSU n.a. A.I. Evdokimov" of RMH

Email: vagrashot@mail.ru
MD, Prof., Head of the Department of Endocrinology and Diabetology

S. Podachina

FSBEI HE "MSMSU n.a. A.I. Evdokimov" of RMH

Department of Endocrinology and Diabetology

M. Sviridova

Treatment and Rehabilitation Center of Ministry of Economic Development of the Russian Federation

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