Features of the clinical manifestations of nets. Carcinoid syndrome

The clinical manifestations of neuroendocrine tumors (NETs) are diverse and can mask other diseases, which leads to a delayed diagnosis and the progression of the disease. Carcinoid syndrome (CS) occurs most frequently and accompanies the development of approximately 20-35% of high-differentiated tumors of the jejunum or ileum, as well as NETs of other localizations. The main manifestations of CS include diarrhea, hot flashes, bronchospasm and carcinoid heart disease (CHD). Somatostatin analogues (SSAs) are the main systemic drugs for CS and CHD. SSAs should be prescribed even in the absence of clinical signs of CS when the biomarker threshold level is exceeded.

NETs, carcinoid syndrome, hot flashes, diarrhea, chromogranin A, hydroxyindoleacetic acid