Do we know all about acetylcysteine?
- Авторлар: Klyachkina I.L.1
-
Мекемелер:
- Russian Medical Academy of Continuous Professional Education
- Шығарылым: Том 28, № 10 (2021)
- Беттер: 103-110
- Бөлім: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/313263
- DOI: https://doi.org/10.18565/pharmateca.2021.10.W3-1W
- ID: 313263
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
Symptomatic therapY., including antipyretics, plays center stage in the treatment of the new coronavirus infection COVID-19. The safest drug is paracetamol, which is included in outpatient treatment regimens for a new coronavirus infection (COVID-19). Paracetamol is considered a well-tolerated drug, however, despite this facT., there is a steady increase in the number of reported cases of paracetamol-induced hepatic intoxication worldwide every year. N-acetylcysteine (NAC) is approved by FDA and therefore recognized by the WHO as an essential drug widely used in the treatment of paracetamol (acetaminophen) overdose.
Негізгі сөздер
Толық мәтін
Авторлар туралы
Irina Klyachkina
Russian Medical Academy of Continuous Professional Education
Email: formozailk2012@yandex.ru
Cand. Sci. (Med.), Associate Professor at the Department of Pulmonology Moscow, Russia
Әдебиет тізімі
- Rushworth G.F., Megson I.L. Existing and potential therapeutic uses for N-acetylcysteine. The need for conversion to intracellular glutathione for antioxidant benefits. Pharmacol Ther 2014;141:150-59. doi: 10.1016/j.pharmthera.2013.09.006.
- Sheffner A.L., et al. the in vitro reduction in viscosity of human tracheobronchial secretions by acetylcysteine. Am Rev Resp Dis. 1964;90:721-29. doi: 10.1164/arrd.1964.90.5.721.
- Aruoma O.I., Halliwell B., Hoey B.M., Butler J. The antioxidant action of N-acetylcysteine:its reaction with hydrogen peroxide and hypochlorous acid. Free Radic Biol Med. 1989; 6(6):593-7.
- AldiniG.,AltomareA.,BaronG.,etal.N-Acetylcysteine as an antioxidant and disulphide breaking agent: The reasons why. Free Radic Res. 2018;52:751-62. doi: 10.1080/10715762.2018.1468564.
- Tenorio M.C. dos S., Graciliano N.G., Moura F.A., at al. N-Acetylcysteine (NAC): Impacts on Human Health. Antioxidants (Basel). 2021;10(6):967. Published on-line 2021 Jun 16. Doi: 10.3390/ antiox10060967.
- Samuni Y., Goldstein S., Dean O.M., Berk M. The chemistryandbiologicalactivitiesofN-acetylcysteine. Biochim Biophys Acta. 2013;1830:4117-29. doi: 10.1080/10715762.2018.1468564.
- Atefi N., Behrangi E., Mozafarpoor S., et al. N-acetylcysteine and coronavirus disease 2019. May it work as a beneficial preventive and adjuvant therapy? A comprehensive review studies. J Res Med Sci. 2020;25:109. Published on-line 2020 Nov 26. doi: 10.4103/jrms.JRMS_777_20.
- Временные методические рекомендации: профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). Версия 11 (07.05.2021)
- Sestili P., Fimognari C. Paracetamol-Induced Glutathione Consumption: Is There a Link With Severe COVID-19 Illness? Front Pharmacol. 2020;11:579944. Published on-line 2020 Oct 7. doi: 10.3389/fphar. 2020.579944
- Временные методические рекомендации: лекарственная терапия острых респираторных вирусных инфекций (ОРВИ) в амбулаторной практике в период эпидемии COVID-19 (версия 2 от 16.04.2020)
- Розенсон О.Л. Вопросы безопасности парацетамола и парацетамол-содержащих препаратов. РМЖ. 1999;20:68- 73
- Jozwiak-Bebenista M., Nowak J.Z. Paracetamol: mechanism of action, applications and safety concern. Acta Pol Pharm. 2014;71(1):11-23.
- Lee W.M. Acute liver failure. Semin Respir Crit Care Med. 2012;33:36-45. doi: 10.1055/s-0032-1301733.
- Yoon E., Babar A., Choudhary M., et al. Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update. J Clin Transllat Hepatol. 2016;4(2):131-42. Doi: 10.14218/ JCTH.2015.00052.
- Lieber C.S. Medical disorders of alcoholism. N Engl J Med. 1995;333:1058-65. Doi: 10.1056/
- Perneger T.V., Whelton P.K., Klag M.J. Risk of kidney failure associated with the use of acetominophen, aspirin, and nonsteroidal antiinflammatory drugs. N Engl J Med. 1994;331:1675-712. Doi:10.1056/ NEJM199412223312502.
- Larson A.M., Polson J., Fontana R.J., et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatol. Wiley-Liss, 2005;42(6):1364-72. doi: 10.1002/hep.20948.
- De Andrade K.Q., Moura F.A., Dos Santos J.M., et al. Oxidative stress and inflammation in hepatic diseases: Therapeutic possibilities of N-Acetylcysteine. Int J Mol Sci. 2015; 16:30269-308. doi: 10.3390/ijms 161226225.
- Chiew A.L., Reith D., Pomerleau A., et al. Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand. Med J Aust. 2020;212:175-83. doi: 10.5694/mja2.50428.
- Jaeschke H. Acetaminophen - Dose-dependent Drug Hepatotoxicity and Acute Liver Failure in Patients. Dig Dis. 2015;33(4):464-71. Published onl-ine 2015 Jul 6. doi: 10.1159/000374090.
- De Flora S., Grassi C., Carati L. Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with longterm N-acetylcysteine treatment. Eur Respir J. 1997;10:1535-41. doi: 10.1183/09031936.97. 10071535.
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