№ 1S (2017)

The article summarizes data on modern methods of phototherapy, indications and contraindications to its appointment, and side effects. Modern literature data on the study of phototherapy in the treatment of dermatoses are presented.

The article presents the results of the evaluation of modern sensitivity indicators to antifungal preparations in 1052 strains of Candida species isolated from patients with urogenital candidiasis in the period from 2010 to 2015. Pathogen culture identified was examined to determine the sensitivity to amphotericin В, 5-fluorocytosine, fluconazole, itraconazole, ketoconazole, and miconazole. At present, along with a predominance of Candida albicans, the etiological range of causative agents of urogenital candidiasis is characterized by an increasing proportion of non-albicans species (Candida glabrata, Candida krusei, Candida parapsilosis). Heterogeneous specific structure of the disease and increase in resistance rates of Candida to commonly used azole antifungals (fluconazole, itraconazole, miconazole) necessitate permanent monitoring of the sensitivity of infectious agents to antifungals and optimizing treatment regimens based on these indicators.

The article presents the modern concept of the treatment of vitiligo, the approaches to the choice of the optimal therapeutic algorithm, ways of assessing the clinical response; also, clinical experience of the authors is reviewed. One case report is discussed in detail. Vitiligo -the most frequent dermatosis from the group of diseases associated with the violation of skin pigmentation. The prevalence of vitiligo in the general population is 1-3%, regardless of gender. The study found that the combined use of needling techniques and NB-UVB (311 nm, TL01) allows achieving repigmentation of lesions in patients with vitiligo in the majority of cases (89.47%).

Over the past 30 years the prevalence of allergic diseases commonly doubled every 10 years. Currently, the problem of allergic rhinitis (AR) can be considered as one of the most pressing. In terms of prevalence, medical and social importance, and impact on health and quality of life of patients, the AR occupies the first place among the other allergic diseases. Over the past few decades a steady increase in the number of patients suffering from this disease has seen in Europe. In the structure of allergic diseases, the proportion of AR is very high (60-70%). According to the results of epidemiological studies, AR affects about 20% of the population in all age groups. The article demonstrates the role of antihistamines in the treatment of AR. Currently, cetirizine, a competitive antagonist of histamine, a metabolite of hydroxyzine, selectively blocking the Hi-receptor, is one of the most effective, safe and cost-effective antihistamines with systemic effects. Furthermore, besides antihistamine effect, cetirizine has the additional anti-inflammatory action. Probability of development of tolerance to the drug is low, so it can be used for a long time. Cetirizine is applied once a day that increases adherence to therapy. Cetirizine has well-proven bioequivalence with an original cetirizine, but is more economically available. Cetirizine is one of the most effective and safe second generation antihistamines.