COMPARISON OF THE EFFECTIVENESS OF INTRAARTICULAR ADMINISTRATION OF ALFLUTOP AND SUPLAZYNE IN PATIENTS WITH OSTEOARTHROSIS OF KNEE AGAINST THE BACKGROUND OF ORAL ADMINISTRATION OF ARTRA

Intraarticular injections of alflutop and hyaluronic acid (GLA) are alternatives to the use of oral chondroprotectors (CP). This provides the required concentration in the target joint, and lead to the more frequent use of this method of drug administration in the treatment of osteoarthrosis of the knee (OK). The study was aimed to evaluation of effectiveness of combined treatment with oral CP in combination with intraarticular injections of GLA or parenteral HP in 72 patients with OK. Combined therapy with oral CP and intra-articular injections of CP and GLA preparations led to marked decrease in the severity of pain syndrome. Furthermore, functional state of the knee joint has improved against the background of using of GLA preparation. Positive results of combined therapy at the late periods can be explained by potentiation of effect oral CP by drugs introduced into the joint.

osteoarthrosis, knee joint, chondroprotectors, intraarticular injections, hyaluronic acid