Sravnitel'nyy analiz neposredstvennoy effektivnosti trekhkomponentnogo (antratsiklinsoderzhashchego) i dvukhkomponentnogo (bezantratsiklinovogo) rezhimov induktsionnoy khimioterapii mestno-rasprostranennogo raka nosoglotki

Therapeutic approach in nasopharyngeal carcinoma (NPC) depends on the extent of the process. Radiation therapy is the main method for treatment of localized forms of NPC. For the treatment of stage I, radiation therapy is used alone; in stage II, optimal treatment option includes simultaneous chemoradiation therapy with the addition of cisplatin. In locally advanced cases (III, IV A-, B-stages), radiation/concurrent chemoradiation therapy is limited by involvement or close proximity of vital structures with low tolerance to radiotherapy. In these situations, the application of induction chemotherapy (IHT) at 1st phase of treatment can be considered as optimal treatment approach. We have developed two IHT regimens (anthracycline - containing an no anthracycline - containing) and evaluated their efficacy and toxicity.

locally advanced nasopharyngeal cancer, induction chemotherapy, efficacy, toxicity