Modern approaches to the diagnosis and treatment of acute pyelonephritis in patients with bladder cancer

Bladder cancer (BC) often leads to a violation of the passage of urine, vesicoureteral reflux and the development of complicated pyelonephritis both before and after treatment of cancer. The data on the main pathogens of acute pyelonephritis (AP) in patients with BC, and modern methods of its diagnosis are presented. Rational approaches to the antibacterial therapy of AP in BC, in which fluoroquinolones play an important role, are discussed. The basic requirements for antimicrobial agents for the empirical therapy of AP in patients with BC, following after the restoration of urine passage, includes a wide spectrum of antimicrobial activity, the ability to create high concentrations in urine and kidney tissue, prolonged pharmacokinetics and safety. Timely diagnosis and rational treatment of AP in patients with RBC allow to improve the quality of life of such a complex category of patients.

acute pyelonephritis, bladder cancer, antimicrobials, fluoroquinolones, antibiotic resistance