ТAPГЕТНАЯ ТЕРАПИЯ ПОСЛЕ ПРОГРЕССИРОВАНИЯ HER2-ПОЗИТИВНОГО РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ


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Аннотация

Обсуждается проблема дальнейшего применения таргетной терапии на основе трастузумаба у больных раком молочной железы (РМЖ) с гиперэкспрессией HER2, получающих такое лечение, у которых наступил рецидив или наблюдается прогрессирование процесса. Представленный в обзоре анализ многочисленных исследований показал, что продолжение при прогрессировании терапии трастузумабом и замена комбинаторного препарата достоверно улучшают результаты лечения РМЖ с гиперэкспрессией HER2. Эта концепция легла в основу рекомендаций NCCN по химиотерапии HER2-позитивного диссеминированного РМЖ в 2009 г., которые с тех пор не претерпели существенных изменений.

Об авторах

Юрьевна Семиглазова Татьяна

ФГБУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития РФ

ФГБУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития РФ

Владислав Владимирович Семиглазов

СПбГМУ им. акад. И.П. Павлова

СПбГМУ им. акад. И.П. Павлова

Валентиновна Филатова Лариса

ФГБУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития РФ

ФГБУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития РФ

Вячеслав Андреевич Чубенко

ФГБУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития РФ

ФГБУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития РФ

Владимирович Брежнев Никита

ФГБУ "НИИ онкологии им Н.Н. Петрова" Минздравсоцразвития РФ

ФГБУ "НИИ онкологии им Н.Н. Петрова" Минздравсоцразвития РФ

Владимирович Моисенко Федор

ФГБУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития РФ

ФГБУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития РФ

Дилором Хамидовна Латипова

ФГБУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития РФ

ФГБУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития РФ

Лазаревич Гершанович Михаил

ФГБУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития РФ

ФГБУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития РФ

T Yu Semiglazova

V V Semiglazov

L V Filatova

V A Chubenko

N V Brejnev

F V Moiseenko

D Latipova

M L Gershanovich

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