Рамиприл: возможности применения при ишемической болезни сердца


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Аннотация

В обзоре рассмотрены возможности использования ингибиторов ангиотензинпревращающего фермента в лечении больных ишемической болезнью сердца (ИБС). Отражены гемодинамические и нейрогуморальные эффекты препаратов этой группы, особенности фармакокинетики. Подробно разобраны исследования, касающиеся одного из препаратов данной группы -рамиприла. Описаны результаты исследований AIRE и HOPE, послуживших основой для включения рамиприла в рекомендации по лечению больных острым инфарктом миокарда и по вторичной профилактике среди больных ИБС с высоким риском осложнений. Приведены доказательства эффективности рамиприла при лечении инфаркта миокарда и возможные механизмы снижения риска осложнений.

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Л. О Минушкина

УНМЦ УД Президента РФ

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