Some approaches for creating of pharmacologically active polymer derivatives of medicines with antitumor activity


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The article describes the main problems associated with currently used anticancer chemotherapy. The main groups of cytotoxic drugs and details of their mechanism of action are presented. General concepts of promising modern method of anticancer therapy, an application of polymer derivatives of medicines, are explained. Polymeric compounds can alter the pharmacokinetics of drugs and increase their blood circulation time due to high molecular weight. This improves the efficiency of the capture of polymeric derivatives by tumor cells, which are characterized by increased endocytosis in contrast to normal cells. The characteristics of polymers (polycations, polyanions and neutral polymers) used for the transport systems of selective drug delivery are discussed. The features of the development of micellar delivery systems and vaccination type systems represented by the classical Ringsdorf model are determined.

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