Personalized approach to the treatment of patients with skin psoriasis and inflammatory back pain, taking into account comorbid pathology

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Backrground. In psoriasis (PS), a complex immune cascade with the participation of both the innate and adaptive immune systems occurs, and is characterized by the development of multiple comorbid pathologies that complicate the course of the underlying disease.

Objective. Evaluation of the safety profile and effectiveness of genetically engineered biological drugs from the group of IL-17A inhibitors (netakimab) in patients with smooth skin PS and inflammatory back pain, taking into account comorbid pathologies.

Methods. 39 patients with PS were followed-up: 21 (53.8%) men and 18 (46.2%) women aged 18–48 years (mean age 35.3±2.1 years), who received the genetic therapy netakimab at a dosage of 120 mg subcutaneously at weeks 0, 1, 2 and then 120 mg every month for 52 weeks.

Results. The majority of patients taking netakimab noted significant positive changes in the skin and joints by the end of the 3rd week of therapy. By week 12, 36 (92.3%) patients achieved PASI 75, 33 (84.6%) – PASI 90 and 31 (79.5%) patients – PASI 100. By week 24, delta PASI 75 was noted in 38 (97.4%) patients, PASI 90 – in 37 (94.9%) patients, PASI 100 – in 35 (89.7%) patients. By week 52, 39 (100%) patients achieved PASI 75, 39 (100%) achieved PASI 90, and 38 (97.4%) patients achieved PASI 100.

Conclusion. IL17-A inhibitors (netakimab) have shown high efficacy and a favorable safety profile against the clinical symptoms of PS, inflammatory back pain (possibly as early signs of psoriatic arthritis) and multiple concomitant comorbid pathologies.

Толық мәтін

Рұқсат жабық

Авторлар туралы

N. Pereverzina

Central State Medical Academy of the Presidential Administration of the Russian Federation; National Medical Research Center of Otorhinolaryngology FMBA

Хат алмасуға жауапты Автор.
Email: natalia.pereverzina@gmail.com

Cand. Sci. (Med.)

Ресей, Moscow; Moscow

L. Kruglova

Central State Medical Academy of the Presidential Administration of the Russian Federation

Email: kruglovals@mail.ru
Ресей, Moscow

Әдебиет тізімі

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Әрекет
1. JATS XML
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2. Рис. 1. Пациент с ПС кожи и множественными коморбидными патологиями

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3. Рис. 2. Число пациентов с достижением конечной точки PAS| 75, PAS| 90, PAS| 100 на фоне применения нетакимаба, %

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4. Рис. 3. Число пациентов с достижением конечной точки ДИКЖ<5 на фоне применения нетакимаба

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5. Рис. 4. Динамика показателей индекса BASDAI (баллы) на фоне применения нетакимаба

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