Effektivnost' antibakterial'noy terapii v kompleksnom lechenii yazvennogo kolita s proyavleniyami sindroma razdrazhennogo kishechnika


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The study was aimed to the evaluation of the efficacy of rifaximin-alpha in the treatment of patients with endoscopic remission of ulcerative colitis and the presence of symptoms similar to irritable bowel syndrome (IBS). The study included 37 patients with confirmed diagnosis of «ulcerative colitis». Quality of life was assessed by IBS-QOL questionnaire, and Beck’s questionnaire was used to assess the level of depression. All patients underwent feces analyses. As part of obligate microflora, number of bifidobacteria and lactobacilli using swab test method was estimated, as well as the presence of opportunistic pathogens of transient flora using dilution method and ELISA. After therapy with enterosoluble antibiotic rifaximin-alpha 800 mg per day for 9 days, incidence of IBS-like symptoms, quality of life and the composition of the luminal microflora of the colon were estimated. As a result of the therapy, marked improvement was noted: stool frequency decreased from 5.1 to 2.5 times a day; quality of life improved and levels of depression decreased; the frequency of complaints of IBS-like symptoms significantly decreased.

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