Grelin i leptin u yunoshey s pubertatnym ozhireniem do i posle provedeniya oral'nogo glyukozotolerantnogo testa


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The study was aimed to the evaluation of the relationship between ghrelin, leptin and metabolic parameters in boys with obesity and overweight before and after the oral glucose tolerance test. The study group included 76 boys with obesity and overweight; the control group consisted of 15 healthy patients. Leptin and ghrelin concentrations were determined by ELISA, the lipids levels of were measured using spectrophotometry. Fasting serum ghrelin, leptin, insulin, growth hormone, triglycerides, cholesterol, HDL and LDL cholesterol, and glucose concentrations were estimated. The study revealed a significant decrease in the concentration of ghrelin and trend to increased growth hormone concentration in this category of patients.

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参考

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