POTENTIALS FOR THE IMPROVEMENT OF TREATMENT OF PATIENTS WITH TYPE 1 DIABETES MELLITUS USING HUMAN ULTRA-LONG INSULIN ANALOGUE DEGLUDEC IN OUTPATIENT SETTINGS


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The study was aimed to the evaluation of of the therapeutic potential of using insulin degludec as a part of basal-bolus insulin therapy in patients with type 1 diabetes mellitus compared with insulin glargine on the basis of the dynamics of indicators of glycemic control, frequency and severity of hypoglycemic conditions and susceptibility to hypoglycemia, as well as assessment of changes of health-related quality of life and mental and emotional status. The study included 46 patients aged >18 years with non-target glycemic control previously treated with insulin glargine for a long time. The main group included 25 patients treated with insulin degludec, control group -21 patients receiving insulin glargine. The observation period lasted for 3 months. The frequency and severity of hypoglycemic episodes, psycho-emotional status of the patients and quality of life were evaluated. The results showed that main group was able to achieve better control of hypoglycemia episodes that supposedly reflected in a higher quality of life and psycho-emotional status of patients. All of this allows to recommend insulin degludec as an effective and safe drug of basal-bolus insulin therapy.

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作者简介

M. Kalashnikova

SBEI HOE "First MSMU n.a. I.M. Sechenov" of RMPH Moscow

A. Zilov

SBEI HOE "First MSMU n.a. I.M. Sechenov" of RMPH PhD, Ässociate Professor, Department of Endocrinology Moscow

D. Yazykova

SBEI HOE "First MSMU n.a. I.M. Sechenov" of RMPH Moscow

N. Likhodey

SBEI HOE "First MSMU n.a. I.M. Sechenov" of RMPH Moscow

V. Fadeev

SBEI HOE "First MSMU n.a. I.M. Sechenov" of RMPH Moscow

参考

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