FACTORS CONTRIBUTING TO THE ACHIEVEMENT OF REMISSION AND DEVELOPMENT OF EXACERBATIONS IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS WITH NO SYSTEMIC MANIFESTATIONS, RECEIVING THERAPY WITH ADALIMUMAB


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The article presents the results of evaluation of the efficacy and safety of adalimumab in 53 children with juvenile idiopathic arthritis without systemic manifestations, as well as the evaluation of the timing and the possibility of reaching of inactive disease, the frequency of exacerbations, as well as their causes and side effects.

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作者简介

M. Kostik

SBEI HPE "Saint Petersburg State Pediatric Medical University" of RMH

Email: kost-mikhail@yandex.ru
PhD, Associate Professor at the Department of Hospital Pediatrics St. Petersburg

M. Dubko

SBEI HPE "Saint Petersburg State Pediatric Medical University" of RMH

St. Petersburg

E. Isupova

SBEI HPE "Saint Petersburg State Pediatric Medical University" of RMH

St. Petersburg

I. Chikova

SBEI HPE "Saint Petersburg State Pediatric Medical University" of RMH

St. Petersburg

E. Gaydar

SBEI HPE "Saint Petersburg State Pediatric Medical University" of RMH

St. Petersburg

V. Masalova

SBEI HPE "Saint Petersburg State Pediatric Medical University" of RMH

St. Petersburg

L. Snegireva

SBEI HPE "Saint Petersburg State Pediatric Medical University" of RMH

St. Petersburg

O. Kalashnikova

SBEI HPE "Saint Petersburg State Pediatric Medical University" of RMH

St. Petersburg

V. Chasnyk

SBEI HPE "Saint Petersburg State Pediatric Medical University" of RMH

St. Petersburg

参考

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  9. Lovell D.J., Giannini E.H., Reiff A., Cawkwell G.D., Silverman E.D, Nocton J.J., Stein L.D., Gedalia A., Ilowite N.T., Wallace C.A., Whitmore J., Finck B.K. Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group. N. Engl. J. Med. 2000;342(11):763-69.
  10. Imagawa T., Takei S., Umebayashi H., Yamaguchi K., Itoh Y., Kawai T., Iwata N., Murata T., Okafuji I., Miyoshi M., Onoe Y., Kawano Y., Kinjo N., Mori M., Mozaffarian N., Kupper H., Santra S., Patel G., Kawai S., Yokota S. Efficacy, pharmacokinetics, and safety of adalimumab in pediatric patients with juvenile idiopathic arthritis in Japan. Clin. Rheumatol. 2012;31(12):1713-21.
  11. Guzman J.,Oen K.,Tucker L.B.,Huber A.M.,Shiff N., Boire G., Scuccimarri R., Berard R., Tse S.M., Morishita K., Stringer E., Johnson N., Levy D.M., Duffy K.W., Cabral D.A., Rosenberg A.M., Larche M., Dancey P., Petty R.E., Laxer R.M., Silverman E., Miettunen P., Chetaille A.L., Haddad E., Houghton K., Spiegel L., Turvey S.E., Schmeling H., Lang B., Ellsworth J., Ramsey S., Bruns A., Campillo S., Benseler S., Chedeville G., Schneider R.,Yeung R., Duffy C.M; ReACCh-Out investigators. The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort. Ann. Rheum. Dis. 2015;74(10): 1854-60.
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