INFLUENCE OF ANTIEPILEPTIC DRUGS ON MOOD AND BEHAVIOR OF THE PATIENTS WITH EPILEPSY


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Experimental and clinical data demonstrate that antiepileptic drugs (AEDs) in addition to anticonvulsive effect can modulate the mood and behavior of the patients with epilepsy. Therapeutic targets may be common - interference with the metabolism of y-aminobutyric acid and neurotransmitters, and also with the function of ion channels of brain. Some AEDs have a specific influence that should be considered for the selection of therapy. Effects on behavior and mood can be multidirectional. Positive effects (for example, with the use of valproate) have long been used not only in neurology but also in psychiatry. Adverse effects (they are regarded as adverse events) can be avoided by awareness on risk groups for their development, or by minimization the degree of severity with decrease in the dose. The review presents modern data on the effect of specific AEDs on the behavior and mood of patients with epilepsy. A more precise definition of psychotropic profile of AEDS will lead to greater individualization of treatment and possibly to the definition of a new strategy of treatment of psychiatric conditions.

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作者简介

E. Belousova

ASS Scientific Research Clinical Institute of Pediatrics n.a. Yu.E. Veltischev; FSBEI HE RNSMU n.a. N.I. Pirogov of RMH

Email: ebelousova@inbox.ru
MD, Prof., Honored Doctor of the Russian Federation, Department of Psychoneurology and Epileptology Moscow

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