ASPIRIN-EXACERBATED RESPIRATORY DISEASE: MECHANISMS OF DEVELOPMENT, DIAGNOSTICS AND TREATMENT


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Aspirin-exacerbated respiratory disease (AERD) most often includes a triad of symptoms: bronchial asthma, rhinosinusitis polyposa, hypersensitivity to acetylsalicylic acid and non-steroidal anti-inflammatory drugs. There are also variants of AERD, limited only to the involvement of the upper respiratory tract. AERD is a multifactorial pathology; lipid mediators, imbalance of congenital and adaptive immune responses, dysfunction of the epithelial barrier, and various external factors play a role in its development. Characteristic features of AERD include T2-endotypes of inflammation, as well as pronounced eosinophilic infiltration of the upper and lower respiratory tract. Diagnosis is based on anamnestic and clinical signs; in the absence of a typical medical history, the diagnosis is confirmed by aspirin provocation test. Treatment includes anti-inflammatory drugs (corticosteroids, anti-leukotriene drugs), exclusion/restriction of triggers and desensitization with aspirin according to strict indications, as well as a new direction - targeted therapy with biological preparations.

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作者简介

I. Vorzheva

Irkutsk State Medical Academy of Postgraduate Education - Branch of the Russian State Medical Academy of Postgraduate Education “Russian Medical Academy of Continuous Professional Education" of the Ministry of Health of the Russian Federation

B. Chernyak

Irkutsk State Medical Academy of Postgraduate Education - Branch of the Russian State Medical Academy of Postgraduate Education “Russian Medical Academy of Continuous Professional Education" of the Ministry of Health of the Russian Federation

Email: ba.chernyak@gmail.com
MD, Prof., Head of the Department of clinical Allergology and Pulmonology

参考

  1. Kowalski M.L., Asero R., Bavbek S., et al. Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs. Allergy. 2013;68:1219-32. doi: 10.1111/all.12260.
  2. Fokkens W.J., Lund V.J., Mullol J., et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinology. 2012;50(Suppl. 23):1-299.
  3. Woessner K.M. Update on Aspirin-Exacerbated Respiratory Disease. Curr. Allergy Asthma Rep. 2017;17:2. Doi: https://doi.org/10.1007/ s11882-017-0673-6.
  4. Steinke J.W., Wilson J.M. Aspirin-exacerbated respiratory disease: pathophysiological insights and clinical advances. J. Asthma Allergy 2016;9:37-43. doi: 10.2147/JAA.S88739.
  5. White A.A., Doherty T.A. Role of group 2 innate lymphocytes in aspirin-exacerbated respiratory disease pathogenesis. Am. J. Rhinol. Allergy. 2018;32:7-11. Doi: 10.2500/ ajra.2018.32.4498.
  6. Parker A.R., Ayars A.G., Altman M.C., Henderson W.R. Lipid Mediators in Aspirin-Exacerbated Respiratory Disease. Immunol. Allergy Clin. North Am. 2016;36:749-63. Doi: 10.1016/j. iac.2016.06.009.
  7. Liu T., Kanaoka Y., Barrett N.A., et al. Aspirin-exacerbated respiratory disease involves a cysteinyl leukotriene-driven IL-33-mediated mast cell activation pathway. J. Immunol. 2015;195:3537-45. Doi: 10.4049/ jimmunol.1500905.
  8. Cahill K.N., Bensko J.C., Boyce J.A., Laidlaw T.M. Prostaglandin D2: A dominant mediator of aspirin-exacerbated respiratory disease. J. Allergy Clin. Immunol. 2015;135:245-52. doi: 10.1016/j.jaci.2014.07.031.
  9. Corrigan C.J., Napoli R.L., Meng Q., et al. Reduced expression of the prostaglandin E2 receptor E-prostanoid 2 on bronchial mucosal leukocytes in patients with aspirin-sensitive asthma. J. Allergy Clin. Immunol. 2012;129:1636-46. doi: 10.1016/j.jaci.2012.02.007.
  10. Narayanankutty A., Reséndiz-Hernández J.M., Falfân-Valencia R., Teran L.M. Biochemical pathogenesis of aspirin exacerbated respiratory disease (AERD). Clin. Biochem. 2013;46:566-78. Doi: 10.1016/j. clinbiochem.2012. 12.005.
  11. Machado-Carvalho L., Torres R., Perez-Gonzalez M., et al. Altered expression and signalling of EP2 receptor in nasal polyps of AERD patients: role in inflammation and remodeling. Rhinology. 2016;54:254-65. Doi: 10.4193/ Rhin15.207.
  12. Yamaguchi T., Ishii T., Yamamoto K., et al. Differences in urinary leukotriene E4 levels and distribution of eosinophils between chronic rhinosinusitis patients with aspirin-intolerant and -tolerant asthma. Auris Nasus Larynx. 2016;43:304-8.
  13. Karta M.R., Broide D.H., Doherty T.A. Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease. Curr. Allergy Asthma Rep. 2016;16:1-19. doi: 10.1007/s11882-015-0581-6.
  14. Buchheit K.M., Cahill K.N., Katz H.R., et al. Thymic stromal lymphopoietin controls prostaglandin D2 generation in aspirin-exacerbated respiratory. J. Allergy Clin. Immunol. 2016;137:1566-76. doi: 10.1016/j.jaci.2015.10.020.
  15. Cavagnero K., Doherty T.A. Cytokine and Lipid Mediator Regulation of Group 2 Innate Lymphoid Cells (ILC2s) in Human Allergic Airway Disease. J. Cytokine Biol. 2017;2:1-17.
  16. Eastman J.J., Cavagnero K.J., Deconde A.S., et al. Group 2 innate lymphoid cells are recruited to the nasal mucosa in patients with aspirin-exacerbated respiratory disease. J. Allergy Clin. Immunol. 2017;140:101-8. Doi: 10.1016/j. jaci.2016.11.023.
  17. Yoo H.S., Shin Y.S., Liu J.N., et al. Clinical Significance of Immunoglobulin E Responses to Staphylococcal Superantigens in Patients with Aspirin-Exacerbated Respiratory Disease. Int. Arch. Allergy Immunol. 2013;162:340-45. doi: 10.1159/000353976.
  18. Kowalski M.L., Cieslak M., Pérez-Novo C.A., et al. Clinical and immunological determinants of severe/refractory asthma (SRA): association with Staphylococcal superantigen-specific IgE antibodies. Allergy. 2011;66:32-8.
  19. Palikhe N.S., Kim S.H., Kim J.H., et al. Role of Tolllike Receptor 3 Variants in Aspirin-Exacerbated Respiratory Disease. Allergy Asthma Immunol. Res. 2011;3:123-27.
  20. Szczeklik A., Nizankowska E., Duplaga M. Natural history of aspirin-induced asthma. Eur. Respir. J. 2000;2:432-36.
  21. Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma (GINA). Updated 2018. Availble from: http://www.ginasthma.org. Accessed 2018 August 14.
  22. Колхир П.В. Доказательная аллергология-иммунология. М., 2010. 528 с. [Kolkhir PV. Evidence-based allergology-immunology. Moscow, 2010. 528 p. (In Russ.)].
  23. Tuttle K.L., Schneider T.R., Henrickson S.E., et al. Aspirin-exacerbated respiratory disease: not always “adult-onset". J. Allergy Clin. Immunol. Pract. 2016;4:756-58.
  24. Kennedy J.L., Stoner A.N., Borish L. Aspirin-exacerbated respiratory disease: Prevalence, diagnosis, treatment, and considerations for the future. Am. J. Rhinol. Allergy. 2016;30:407-13. doi: 10.2500/ajra.2016.30.4370.
  25. Food hypersensitivity; diagnosing food allergies and intolerans. Ed. I. Skypala, C. Venter. Chichester, UK, 2009. 371 p.
  26. Воржева И.И. Аспириновая бронхиальная астма: особенности диагностики и лечения. Практическая пульмонология. 2015;2:2-12. [Vorzheva I.I. Aspirin bronchial asthma: features of diagnosis and treatment. Prakticheskaya pul'monologiya. 2015;2:2-12. (In Russ.)].
  27. Dahlén S.E., Malmström K., Nizankowska E. Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebocontrolled trial. Am. J. Respir. Crit. Care Med. 2002;165(1):9-14. Doi: 10.1164/ ajrccm.165.1.2010080.
  28. Paganin F., Poubeau P., Yvin J.L., Arvin-Berod C. The effectiveness of leukotriene antagonists in the treatment of aspirin-intolerant asthmatic patients. Pres. Med. 2003;32:978-84.
  29. Wentzel J.L., Soler Z.M., DeYoung K., et al. Leukotriene antagonists in nasal polyposis: a meta-analysis and systematic review. Am. J. Rhinol.Allergy2013;27:482-89. Doi: 10.2500/ ajra.2013.27.3976.
  30. Российское респираторное общество, Педиатрическое респираторное общество. Федеральные клинические рекомендации по диагностике и лечению бронхиальной астмы. М., 2016. Доступно по: www.spulmo.ru. Ссылка активна на 12.05.2018. [Russian respiratory society, Pediatric respiratory society. Federal clinical guidelines for the diagnosis and treatment of bronchial asthma. Moscow, 2016. www.spulmo.ru. The link is active on 12.05.2018. (In Russ.)].
  31. Levy J.M., Rudmik L., Peters A.T., et al. Contemporary management of chronic rhinosinusitis with nasal polyposis in aspirin exacerbated respiratory disease: an evidence-based review with recommendations. Int. Forum Allergy Rhinol. 2016;6:1273-83. doi: 10.1002/alr.21826.
  32. Bobolea I., Barranco P., Fiandor A., et al. Omalizumab: A Potential New Therapeutic Approach for Aspirin-Exacerbated Respiratory Disease. J. Investig. Allergol. Clin. Immunol. 2010;20:446-53.
  33. Aksu K., Kurt E. Aspirin tolerance following omalizumab therapy in a patient with aspirin-exacerbated respiratory disease. Allergol. Immunopathol. (Madr.). 2013;41:208-10.
  34. Bergmann K.C., Zuberbier T., Church M.K. Omalizumab in the treatment of aspirin-exacerbated respiratory disease. J. Allergy Clin. Immunol. Pract. 2015;3:459-3260.
  35. Gevaert P., Calus L., Van Zele T., et al. Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma. J. Allergy Clin. Immunol. 2013;131:110-16. Doi: 10.1016/j. jaci.2012.07.047.
  36. Nair P., Pizzichini M.M., Kjarsgaard M., et al. Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia. N. Engl. J. Med. 2009;360:985-93. Doi: 10.1056/ NEJMoa0805435.
  37. Gevaert P., Van Bruaene N., Cattaert T., et al. Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis. J. Allergy Clin. Immunol. 2011;128:989-95.
  38. Varricchi G., Senna G., Loffredo S., et al. Reslizumab and Eosinophilic Asthma: One Step Closer to Precision Medicine? Front. Immunol. 2017;8:242. Doi: 10.3389/ fimmu.2017.00242.
  39. Farne H.A., Wilson A., Powell C., et al. Anti-IL5 therapies for asthma. Cochrane Database Syst. Rev. 2017. Sep 21;9:CD010834. doi: 10.1002/14651858.CD010834.pub3.
  40. Morales D.R., Lipworth B.J., Guthrie B., et al. Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: Meta-analysis of controlled clinical trials. J. Allergy Clin. Immunol. 2014;134:40-5. Doi: 10.1016/j. jaci.2013.10.057.
  41. White A.A., Stevenson D.D., Woessner K.M., Simon R.A. Approach to patients with aspirin hypersensitivity and acute cardiovascular emergencies. Allergy. Asthma Proc. 2013;34:138-42.
  42. Fruth K., Pogorzelski B., Schmidtmann I., et al. Low-dose aspirin desensitization in individuals with aspirin exacerbated respiratory disease. Allergy. 2013;68:659-65. Doi: 10.1111/ all.12131.
  43. Sommer D.D., Rotenberg B.W., Sowerby L.J., et al. A novel treatment adjunct for aspirin exacerbated respiratory disease: the low-salicylate diet: a multicenter randomized control crossover trial. Int. Forum Allergy Rhinol. 2016;6:385-91. Doi: https://doi.org/10.1002/alr.21678.
  44. Cho K.S., Soudry E., Psaltis A.J., et al. Long-term sinonasal outcomes of aspirin desensitization in aspirin exacerbated respiratory disease. Otolaryngol. Head Neck Surg. 2014;151:575 81. doi: 10.1177/0194599814545750
  45. Dalmau G., Gaig P., Gazquez V., Merceb J. Rapid Desensitization to Acetylsalicylic Acid in Acute Coronary Syndrome Patients With NSAID Intolerance. Rev. Esp. Cardiol. 2009; 62:224-30

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