Endocrinopathies induced by immune check point inhibitors. Optimal patient management tactics


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详细

The objective of this review is to summarize the current experience in the management of various complications from the endocrine system in cancer patients who receive immune checkpoint inhibitors. Rational modern immunotherapy of oncological diseases can significantly increase the life expectancy and quality of life of patients. At the same time, the development of a wide range of immune-mediated side effects resulting from dysregulation of the immune system significantly worsens treatment outcomes. Immune checkpoint inhibitors can cause dysfunction of the endocrine glands - thyroid, pituitary, adrenal glands and pancreas, as well as their combined damage. The review discusses the prevalence of endocrinopathies, their early diagnosis in the treatment with various immune checkpoint inhibitors, algorithms for the treatment of endocrinopathies, which allow to increase the life expectancy of patients with malignant neoplasms and can be used by practicing endocrinologists in their daily practice.

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作者简介

Larisa Khamnueva

Irkutsk State Medical University

Email: hamnueval@mail.ru
Dr. Sci. (Med.), Professor, Head of the Department of Endocrinology, Clinical Pharmacology and Immunology 1, Krasnogo Vosstaniya str., Irkutsk 664003, Russian Federation

K. Sergeeva

Irkutsk State Medical University

Irkutsk, Russia

L. Andreeva

Irkutsk State Medical University

Irkutsk, Russia

A. Davydova

Irkutsk State Medical University

Irkutsk, Russia

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