The role of some factors of systemic inflammation in the course of gastrointestinal neuroendocrine tumors

Background. The increase in the incidence of neuroendocrine neoplasms creates the need for an active search for factors that determine both the prognosis of the disease and the effectiveness of antitumor treatment. Markers of chronic systemic inflammation are a predisposing factor for many features of malignancy, including neuroendocrine tumors. Thus, the determination of inflammatory biomarkers is highly relevant. Objective. Evaluation of the prognostic role of the neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), platelet to lymphocyte ratio (PLR) and lymphocyte to monocyte ratio (LMR), the effect of the above factors on progression-free survival (PFS) and overall survival rate in patients with gastrointestinal neuroendocrine tumors (GINET) who received treatment at the City Clinical Oncological Dispensary from 2015 to 2020 (NET Register). Methods. The analysis of data of 69 patients with I-IV stage GINET was carried out. All patients received treatment according to standard protocols from 2015 to 2020. The demographic data of all patients, their baseline levels of leukocytes, neutrophils, lymphocytes, monocytes and platelets were analyzed. Results. The relative number of peripheral blood lymphocytes at the stage of initial assessment was the only independent factor influencing the PFS of patients: relative number of lymphocytes ŒŒŒŒ≤30% significantly increased the risk of disease progression (RR=0.97, 95% CI: 0.94-0.99; P=0.0344). Conclusion. The results obtained indicate the possibility of using indicators characterizing systemic inflammation to predict the course of GINET.

neuroendocrine tumor, systemic inflammatory factors, time without progression