Experience with the use of baricitinib in the treatment of atopic dermatitis in HIV-infected patients
- 作者: Evdokimov E.Y.1, Ponezheva Z.B1, Svechnikova E.V2,3, Gruzdev B.M4
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隶属关系:
- Central Research Institute of Epidemiology
- Polyclinic № 1 of the Administrative Department of the President of the Russian Federation
- Novosibirsk State Medical University
- Infectious Clinical Hospital № 2 of the Moscow Healthcare Department
- 期: 卷 29, 编号 10 (2022)
- 页面: 26-30
- 栏目: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/321081
- DOI: https://doi.org/10.18565/pharmateca.2022.10.26-30
- ID: 321081
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详细
Background. Among HIV-infected patients, atopic dermatitis (AD) occurs more frequently by 30% than in patients without HIV infection, and is characterized by severe dermatological symptoms and severe skin itch. For this reason, the treatment of AD and pruritus in HIV-infected patients remains relevant. Objective. Evaluation of the possibility of using the baricitinib in HIV-infected patients with AD. Methods. 6 HIV-infected patients with AD were followed-up; all patients received antiretroviral therapy (ART). There were 4 men (66.7%), 2 women (33.3%). The median age was 32.7 years (21-43). The mean duration of AD was 14.5 years (min - 7.1 years, max - 22). SCORAD - 74.8 (min - 28, max - 89). The mean duration of HIV infection was 3.8 years (min - 0.7 years, max - 11 years), the duration of ART averaged 3.4 years (min - 0.5 years, max - 9.6). All patients were examined before prescribing baricitinib. Results. In HIV-infected patients with AD, a pronounced clinical improvement in the general condition, a significant decrease in skin itching, and a decrease in the intensity of dermatological symptoms were noted after 12 weeks. There was no deterioration in the indicators of HIV infection (clinical course, decrease in the number of CD4+ lymphocytes, an increase in the viral load of HIV). Conclusion. Baricitinib in HIV-infected patients can be used for the treatment moderate to severe AD.
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作者简介
Evgeny Evdokimov
Central Research Institute of Epidemiology
Email: evdokimovevg@yandex.ru
Cand. Sci. (Med.), Researcher at the Clinical Department Moscow, Russia
Zh. Ponezheva
Central Research Institute of EpidemiologyMoscow, Russia
E. Svechnikova
Polyclinic № 1 of the Administrative Department of the President of the Russian Federation; Novosibirsk State Medical UniversityMoscow, Russia; Russia
B. Gruzdev
Infectious Clinical Hospital № 2 of the Moscow Healthcare DepartmentMoscow, Russia
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