Efficacy of intraovarian administration of platelet-rich plasma in infertility treatment programs using assisted reproductive technologies

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Background. Current trends in delayed motherhood dictate the search for new solutions to maintain women’s reproductive health. An increase in the average age of primiparas up to 30–40 years is unshakably accompanied by physiological aging of the ovaries and, accordingly, a decrease in the quality and number of germ cells.

Material and methods. The article highlights the results of the introduction of autologous platelet-rich plasma into the ovary. The analysis of clinical and anamnestic characteristics of patients, hormonal profile and the effectiveness of the procedure in preparation for in vitro fertilization programs was carried out.

Conclusion. The effectiveness of the autologous administration of platelet-rich plasma opens up new opportunities for patients with reduced ovarian reserve and certain hormonal profile parameters, but further research is required in this area.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Yu. Fortygina

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: e_kulakova@oparina4.ru
ORCID iD: 0000-0002-1251-0505
Ресей, Moscow

Elena Kulakova

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Хат алмасуға жауапты Автор.
Email: e_kulakova@oparina4.ru
ORCID iD: 0000-0002-4433-4163

Dr. Sci. (Med.), Senior Researcher at the Department of Assistive Technologies in the Treatment of Infertility n.a. Professor B.V. Leonov

Ресей, Moscow

N. Makarova

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: e_kulakova@oparina4.ru
Ресей, Moscow

T. Teterina

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: e_kulakova@oparina4.ru
ORCID iD: 0000-0003-0990-2302
Ресей, Moscow

I. Apolikhina

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: e_kulakova@oparina4.ru
ORCID iD: 0000-0002-4581-6295
Ресей, Moscow

E. Kalinina

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: e_kulakova@oparina4.ru
ORCID iD: 0000-0002-8922-2878
Ресей, Moscow

Әдебиет тізімі

  1. Navali N., et al. Intraovarian Injection of Autologous Platelet-Rich Plasma Improves Therapeutic Approaches in The Patients with Poor Ovarian Response: A Before-After Study. Int J Fertil Steril. 2022;16(2):90–4. doi: 10.22074/IJFS.2021.533576.1154.
  2. Herlihy N.S., Seli E. The use of intraovarian injection of autologous platelet rich plasma (PRP) in patients with poor ovarian response and premature ovarian insufficiency. Curr Opin Obstet Gynecol. 2022;34(3):133–37. doi: 10.1097/GCO.0000000000000784.
  3. Panda S.R., Sachan S., Hota S. A Systematic Review Evaluating the Efficacy of Intra-Ovarian Infusion of Autologous Platelet-Rich Plasma in Patients With Poor Ovarian Reserve or Ovarian Insufficiency. Cureus. 2020. P. 2017–18.
  4. Merhi Z., Seckin S., Mouanness M. Intraovarian PRP Injection Improved Hot Flashes in a Woman With Very Low Ovarian Reserve. Reprod Sci Reprod. Sci. 2022;29(2):614–19. doi: 10.1007/s43032-021-00655-7.
  5. Sills E.S., Wood S.H. Epigenetics, ovarian cell plasticity, and platelet-rich plasma: Mechanistic theories. Reprod Fertil. 2022;3(4):44–51. doi: 10.1530/RAF-22-0078.
  6. Bachelot A., et al. Long-term outcome of ovarian function in women with intermittent premature ovarian insufficiency. Clin Endocrinol (Oxf). 2017;86(2):223–28. doi: 10.1111/cen.13105.
  7. Sills E.S. Why might ovarian rejuvenation fail? Decision analysis of variables impacting reproductive response after autologous platelet-rich plasma. Minerva Obstet Gynecol. 2022;74(4):377–85. doi: 10.23736/S2724-606X.22.04996-X.
  8. Sills E.S., Wood S.H. Appraisal of Experimental Methods to Manage Menopause and Infertility: Intraovarian Platelet-Rich Plasma vs. Condensed Platelet-Derived Cytokines. Med. (Kaunas). 2021;58(1):3. doi: 10.3390/medicina58010003.
  9. Sills E.S., Tan S.L. Population Dynamics, Plasma Cytokines and Platelet Centrifugation: Technical and Sociodemographic Aspects of ‘Ovarian Rejuvenation’. Clin Pract. 2023;13(2):435–41. doi: 10.3390/clinpract13020039.
  10. Garavelas A., et al. Clinical Benefit of Autologous Platelet-Rich Plasma Infusion in Ovarian Function Rejuvenation: Evidence from a Before-After Prospective Pilot Study. Medicines (Basel). 2023;10(3):19. doi: 10.3390/medicines10030019.
  11. Atkinson L., Martin F., Sturmey R.G. Intraovarian injection of platelet-rich plasma in assisted reproduction: Too much too soon? Hum Reprod. 2021;36(7):1737–50. doi: 10.1093/humrep/deab106.
  12. Seckin S., et al. Ovarian response to intraovarian platelet-rich plasma (PRP) administration: hypotheses and potential mechanisms of action. J Assist Reprod Genet. 2022;39(1):37–61. doi: 10.1007/s10815-021-02385-w.
  13. Lange-Consiglio A., et al. Platelet-rich plasma and ovarian quiescence: a bovine in vitro model for regeneration of the ovary. Reprod Fertil Dev. 2023;35(7):433–44. doi: 10.1071/RD23017.
  14. Bostancı M.S., et al. The effect of protection of platelet‐rich plasma against experimental ischemia/reperfusion injury in the rat ovary on in vitro fertilization outcomes. J Obstet Gynaecol Res. 2022;48(6):1390–98. doi: 10.1111/jog.15232.
  15. Hajipour H., et al. An update on platelet-rich plasma (PRP) therapy in endometrium and ovary related infertilities: clinical and molecular aspects. Syst Biol Reprod Med. 2021:67(3):177–88. doi: 10.1080/19396368.2020.1862357.
  16. Efendieva Z., et al. Hysteroscopic injections of autologous endometrial cells and platelet-rich plasma in patients with thin endometrium: a pilot randomized study. Sci Rep. 2023;13(1):945. doi: 10.1038/s41598-023-27982-w.
  17. Aflatoonian A., et al. Effects of Intraovarian Injection of Autologous Platelet-Rich Plasma on Ovarian Rejuvenation in Poor Responders and Women with Primary Ovarian Insufficiency. Reprod Sci. Reprod. Sci. 2021;28(7): 2050–59. doi: 10.1007/s43032-021- 00483-9.
  18. Kulakova E.V., et al. Birth of a healthy baby in a patient with diminished ovarian reserve after intraovarian autologous platelet-rich plasma injection and an in vitro fertilization program. Akush Ginekol. (Sofiia). 2022; 5(2022):157–61.
  19. Kraevaya E.E., et al. Spontaneous pregnancy in a patient with premature ovarian failure after ovarian platelet-rich plasma injection. Case report. Gynecol. 2021;23(6):597–600.

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