Therapeutic horizons of indirect oral anticoagulants

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

The review article is devoted to summarizing the data on the use of indirect oral anticoagulants (IOACs). A broad therapeutic platform for preventing thrombotic complications using drugs of this group is shown. The prospects for the use of IOACs in patients with new coronavirus infection are indicated. A promising domestic drug of this group has been named, which, among well-known competitors such as rivaroxaban, apixaban, edoxaban and betrixaban, shows one of the lowest concentrations required to double prothrombin time, which researchers associate with tight binding between the ligand-drug and the amino acids Gly216 and Gly218 target protein.

全文:

受限制的访问

作者简介

Sergey Zakharov

Korolev City Hospital

编辑信件的主要联系方式.
Email: zakharov-sv@inbox.ru
ORCID iD: 0009-0002-1565-6304

Neurologist

俄罗斯联邦, Moscow region Korolev

A. Savchenko

Scientific Center for Biomedical Technologies of the Federal Medical and Biological Agency of Russia

Email: zakharov-sv@inbox.ru
ORCID iD: 0000-0003-2734-5036
俄罗斯联邦, Moscow region, Svetlye Gory

参考

  1. Weinberg E.M., Palecki J., Reddy K.R. Direct-acting Oral Anticoagulants (DOACs) in cirrhosis and cirrhosis-associated portal vein thrombosis. Semin Liver Dis. 2019;39(2):195–208. doi: 10.1055/s-0039-1679934.
  2. Сомонова О.В., Елизарова А.Л. Возможности апиксабана в лечении и профилактике рецидивов онкоассоциированных тромбозов. Лечебное дело. 2023;(1):45–51. [Somono-va O.V., Elizarova A.L. Abilities of apixaban in treatment and prevention of recurrent cancer-associated thrombosis. Lech Delo. 2023;(1):45–51. (In Russ.)]. doi: 10.24412/2071-5315-2023-12947.
  3. Середавкина Н.В., Решетняк Е.М., Сатыбалдые-ва М.А. и др. Эффективность и переносимость селективных и неселективных ингибиторов Ха-фактора при антифосфолипидном синдроме и системной красной волчанке: уровень анти-Ха-активности. Терапевтический архив. 2019;(5):19–25. [Seredavkina N.V., Reshetny-ak T.M., Satybaldyeva M.A., et al. Effectiveness and safety of selective and non-selective factor Xa inhibitors in antiphospholipid syndrome and systemic lupus erythematosus: anti-Xa-activity range. Ter Arkh. 2019;(5):19–25. (In Russ.)]. doi: 10.26442/00403660.2019.05.000235.
  4. Gibson P.S. Anticoagulants and pregnancy: when are they safe? Сlevel Clin J Med. 2009;76(2):113–27. doi: 10.3949/ccjm.75a.072272.
  5. Buller H.R., Prins M.H., Lensin A.W. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med. 2012;366(14):1287–97. doi: 10.1056/nejmoa1113572.
  6. Bauersachs R., Berkowitz S.D., Brenner B. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med. 2010;363(26):2499–510. doi: 10.1056/nejmoa1007903.
  7. European medicines agency. Annex I summary of product characteristics. 2018. Available from: URL: https://www.ema.europa.eu/en/documents/product-information/xarelto-epar-product-information_en.pdf.
  8. Patel M.R., Mahaffey K.W., Garg J., et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365(10):883–91. doi: 10.1056/nejmoa1009638.
  9. Jiang H., Jiang Y., Ma H., et al. Effects of rivaroxaban and warfarin on the risk of gastrointestinal bleeding and intracranial hemorrhage in patients with atrial fibrillation: Systematic review and meta‐analysis. Clin Cardiol. 2021;44(9):1208–15. doi: 10.1002/clc.23690.
  10. Gibson W.J., Gibson C.M., Megan K., et al. Safety and efficacy of rivaroxaban when added to aspirin monotherapy among stabilized post‐acute coronary syndrome patients: A pooled analysis study of ATLAS ACS‐TIMI 46 and ATLAS ACS 2‐TIMI 51. JAHA. 2019;8(5):e009451. doi: 10.1161/JAHA.118.009451.
  11. Anderson D.R., Dunbar M., Murnaghan J., et al. Aspirin or Rivaroxaban for VTE prophylaxis after hip or knee arthroplasty. N Engl J Med. 2018;378 (8):699–707. doi: 10.1056/nejmoa1712746.
  12. Martinez Licha C.R., McCurdy C.M., Maldonado S.M., Lee L.S. Current management of acute pulmonary embolism. Ann Thorac Cardiovasc Surg. 2020;26 (2):65–71. doi: 10.5761/atcs.ra.19-00158.
  13. Le G., Yang C., Zhang M., et al. Efficacy and safety of aspirin and rivaroxaban for venous thromboembolism prophylaxis after total hip or knee arthroplasty. A protocol for meta-analysis. Medicine (Baltimore). 2020;99 (49):e23055. doi: 10.1097/md.0000000000023055.
  14. Федина Л.В., Сычев Б.Н., Сычев Д.А. Актуальность использования фармакогенетического подхода для прогнозирования индивидуальных особенностей фармакокинетики и профиля безопасности апиксабана. Фармакогенетика и фармакогеномика. 2021;(1):4–8. [Fedina L.V., Sychev B.N., Sychev D.A. Importance of using a pharmacogenetic approach to predict individual pharmacokinetics and safety profile of apixaban. Farmakogenet. Farmakogenom. 2021;(1):4–8. (In Russ.)]. doi: 10.37489/2588-0527-2021-1-4-8.
  15. Connolly S.J., Eikelboom J., Joyner C., et al. Apixaban in patients with atrial fibrillation. N Engl J Med. 2011;364:806–17. doi: 10.1056/nejmoa1007432.
  16. Granger C.B., Alexander J.H., McMurray J.J., et al. Apixaban versus Warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365:981–92. doi: 10.1056/nejmoa1107039.
  17. Lassen M.R., Raskob G.E., Gallus A., et al. Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial. Lancet. 2010;375(9717):807–15. doi: 10.1016/s0140-6736(09)62125-5.
  18. Picard F., Van Ganse E., Ducrocq G., et al. Evaluation of ApiXaban in strOke and systemic embolism prevention in patients with non-valvular atrial fibrillation in clinical practice Setting in France, rationale and design of the NAXOS: SNIIRAM study. Clin Cardiol. 2019;42(10):851–59. doi: 10.1002/clc.23231.
  19. Панченко Е.П., Балахонова Т.В., Данилов Н.М. и др. Диагностика и лечение тромбоэмболии легочной артерии: клинические рекомендации для практических врачей Евразийской ассоциации кардиологов. Евразийский кардиологический журнал. 2021;(1):6–43. [Panchenko E.P., Balahonova T.V., Danilov N.M., et al. Diagnosis and management of pulmonary embolism eurasian association of cardiology (eac) clinical practice guidelines (2021). Evraz. Сardiol. J. 2021;(1):6–43. (In Russ.)]. doi: 10.38109/2225-1685-2021-1-44-77.
  20. Eikelboom J.W. Explaining the RE-LY trial. Can. J. Hosp. Pharm. 2010;63(4):334–6. doi: 10.4212/cjhp.v63i4.941.
  21. Bartlett J.W., Renner E., Mouland E., et al. Clinical safety outcomes in patients with nonvalvular atrial fibrillation on Rivaroxaban and Diltiazem. Ann Pharmacother. 2019;53(1):21–7. doi: 10.1177/1060028018795140.
  22. Божкова С.А., Касимова А.Р., Накопия В.Б., Корнилов Н.Н. Все ли мы знаем о профилактике венозных тромбоэмболических осложнений после больших ортопедических операций? Травматология и ортопедия России. 2018;24(1):129–43. [Bozhkova S.A., Kasimova A.R., Nakopia V.B., Kornilov N.N. Do we know all about prevention of venous thromboembolism after major orthopedic surgery? Travmatol. Ortoped. Ros. 2018;24(1):129–43. (In Russ.)]. doi: 10.21823/2311-2905-2018-24-1-129-143.
  23. Российские клинические рекомендации по диагностике, лечению и профилактике венозных тромбоэмболических осложнений (ВТЭО). Флебология. 2015;9(4–2):1–52. [Russian clinical guidelines for the diagnosis, treatment and prevention of venous thromboembolic complications (VTEC). Flebol. 2015;9(4–2):1–52. (In Russ.)].
  24. Переверзев А.П., Остроумова О.Д., Ткачева О.Н., Котовская Ю.В. Осложнения фармакотерапии новыми оральными антикоагулянтами, вызванные межлекарственным взаимодействием: акцент на желудочно-кишечные кровотечения. Безопасность и риск фармакотерапии. 2019;7(2):65–71. [Pereverzev A.P., Ostroumova O.D., Tkacheva O.N., Kotovskaya Yu.V. Complications of Pharmacotherapy with New Oral Anticoagulants Caused by Inter-Drug Interactions: Focus on Gastrointestinal Bleeding. Bezopasnost’ i risk farmakoterapii. 2019;7(2):65–71. (In Russ.)]. doi: 10.30895/2312-7821-2019-7-2-65-71.
  25. Кузнецова С.А., Васильева Н.Ю., Дроз Н.Н. и др. Сульфатированные производные арабиногалактана и их антикоагулянтная активность. Химия растительного сырья. 2019;(4):47–56. [Kuznetsova S.A., Vasil’eva N.Yu., Droz N.N., et al. Sulfated arabinogalactan derivatives and their anticoagulant activity. Khimiya rastitel’nogo syr’ya. 2019;(4):47–56. (In Russ.)]. doi: 10.14258/jcprm.2019044845.
  26. Титаева Е.В., Добровольский А.Б. Хромогенный антиХа-тест: соотношение между единицами активности гепарина и концентрацией апиксабана и ривароксабана. Атеротромбоз. Специальный медицинский журнал. 2020;(2):96–104. doi: 10.21518/2307-1109-2020-2-96-104. [Titaeva E.V., Dobrovol’skiy A.B. Chromogenic anti-Xa test: the ratio between heparin activity units and concentration of apixaban and rivaroxaban. Aterotromboz. Spets Med J. 2020;(2):96–104. (In Russ.)].
  27. Talasaz A.H., Sadeghipour P., Kakavand H., et al. Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021;77(15):1903–21. doi: 10.1016/j.jacc.2021.02.035.
  28. Bohula E.A., Giugliano R.P., Leiter L.A., et al. Inflammatory and cholesterol risk in the FourIier trial. Circulation. 2018;138(2):131–40. doi: 10.1161/circulationaha.118.034032.
  29. Bikdeli B., Madhavan M.V, Jimenez D., et al. COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020;75(23):2950–73. doi: 10.1016/j.jacc. 2020.04.031.
  30. National Prescription Audit (NPA) and IMS. Total patient tracker (TPT) databases. October 2010-December 2013. Available from: URL: https://www.iqvia.com/insights/the-iqvia-institute/available-iqvia-data.
  31. Nadkarni G.N. Lala A., Bagiella E., et al. Anticoagulation, Bleeding, Mortality, and Pathology in Hospitalized Patients With COVID-19. J Am Coll Cardiol. 2020;76(16):1815–26. doi: 10.1016/j.jacc.2020.08.041.
  32. SIGN. Prevention and management of venous thromboembolism: a national clinical guideline. Edinburgh: SIGN, 2010.
  33. Santos B.C., Flumignan R.L., Civile V.T., et al. Prophylactic anticoagulants for non-hospitalised people with COVID-19 (Protocol). Cochrane Database Syst Rev. 2023;8(8):CD015102. doi: 10.1002/14651858.cd015102.pub2.
  34. Khadse A.N., Sharma M.K., Murumkar P.R., et al. Advances in the development of novel factor Xa inhibitors: A patent review. Mini Rev Med Chemistry. 2018;18(16):1332–53. doi: 10.2174/1389557518666180424120726.
  35. Tovbin D.G., Tarasov D.N., Malakhov D.V., et al. The development of new low-molecular-weight factor Xa inhibitors that are potential anticoagulants. Curr Drug Discov Technol. 2022;19(1):e010921191770. doi: 10.2174/1568009621666210224104940.
  36. Fredenburgh J.C., Weitz J.I. News at XI: moving beyond factor Xa inhibitors. J. Thromb. Haemostas. 2023;21(7):1692–702. doi: 10.1016/j.jtha.2023.04.021.
  37. Гильдеева Г.Н., Чапленко А.А., Юрков В.И., Степанова Е.С. Сравнительное изучение биоэквивалентности препаратов, содержащих ривароксабан, при однократном приеме здоровыми добровольцами. Безопасность и риск фармакотерапии. 2022;10(3):293–301. [Gildeeva G.N., Chaplenko A.A., Yurkov V.I., Stepanova E.S. Single-Dose Bioequivalence Study of Rivaroxaban-Containing Medicinal Products in Healthy Volunteers. Bezopasnost’ i risk farmakoterapii. 2022;10(3):293–301. (In Russ.)]. doi: 10.30895/2312-7821-2022-10-3-293-301.
  38. Quan M.L., Pinto D.J.P., Smallheer J.M., et al. Factor XIa inhibitors as new anticoagulants. J Med Chem. 2018;61(17):7425–47. doi: 10.1021/acs.jmedchem.8b00173.
  39. Shulga D.A., Tserkovnikova N.A., Tarasov D.N., Tovbin D.G. Investigation of the tight binding mechanism of a new anticoagulant DD217 to factor Xa by means of molecular docking and molecular dynamics. J Biomol Struct Dyn. 2022;41:4723–34. doi: 10.1080/07391102.2022.2072387.
  40. Tarasov D.N., Tovbin D.G., Malakhov D.V., et al. The development of new factor Xa inhibitors based on amide synthesis. Curr Drug Discov Technol. 2018;15(4):335–50.

补充文件

附件文件
动作
1. JATS XML
下载
##common.cookie##