The use of natural mineral water Donat for functional gastrointestinal disorders in comorbid patients: connective tissue dysplasia is in focus

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The review examines the possibilities of natural mineral waters rich in magnesium sulfate in functional gastrointestinal disorders. To date, three magnesium sulfate-rich natural mineral waters have been studied in randomized, double-blind, placebo-controlled clinical trials. A comparison of the effectiveness of the three studied mineral waters showed that the mineral water Donat is more effective. The results of a randomized clinical trial of mineral water Donat in the treatment of functional constipation are considered in detail, as well as the experience of its use in domestic studies that have demonstrated the effectiveness and safety of therapeutic mineral water Donat in pediatric practice and in adult patients with functional gastrointestinal disorders and, first of all, functional constipation.

The characteristics of the natural mineral water Donat allow us to consider it as the first choice for the treatment and prevention of functional gastrointestinal disorders in certain categories of comorbid patients. The rationale for the use of mineral water Donat for the treatment and prevention of the syndrome of pathology of the digestive system in connective tissue dysplasia is given. Mineral water Donat in patients with connective tissue dysplasia is an additional source of trace elements, primarily magnesium, which has a positive effect on other clinical manifestations.

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作者简介

Dmitry Trukhan

Omsk State Medical University

编辑信件的主要联系方式.
Email: dmitry_trukhan@mail.ru
ORCID iD: 0000-0002-1597-1876

Dr. Sci. (Med.), Associate Professor, Professor of the Chair of Polyclinic therapy and Internal Diseases

俄罗斯联邦, Omsk

Maria Rozhkova

Omsk State Medical University

Email: marroj@mail.ru
ORCID iD: 0000-0002-7695-149X

Cand. Sci. (Med.), Associate Professor of the Chair of Polyclinic Therapy and Internal Diseases

俄罗斯联邦, Omsk

Victoria Goloshubina

Omsk State Medical University

Email: vikulka03@mail.ru
ORCID iD: 0000-0003-1481-8842

Cand. Sci. (Med.), Associate Professor of the Chair of Polyclinic Therapy and Internal Diseases

俄罗斯联邦, Omsk

Polina Shuganova

Omsk State Medical University

Email: docanilop@mail.ru
ORCID iD: 0009-0009-9935-2164

Assistant of the Chair of Polyclinic Therapy and Internal Diseases

俄罗斯联邦, Omsk

参考

  1. Трухан Д.И. Функциональные гастроинтестинальные расстройства: перспективы использования лечебной минеральной воды. Медицинский совет. 2017;5:70-76. [Trukhan D.I. Functional gastrointestinal disorders: prospects of using therapeutic mineral water. Meditsinskiy Sovet. 2017;5:70-76. (In Russ.)]. https://dx.doi.org/10.21518/2079-701X-2017-5-70-76
  2. Ефименко Н.В. Механизмы действия питьевых минеральных вод и их роль в курортной гастроэнтерологии. Курортная медицина. 2015;3:2-7. [Efimenko N.V. Mechanisms of action of drinking mineral waters and their role in resort gastroenterology. Kurortnaya meditsina. 2015;3:2–7. (In Russ.)].
  3. Fornai M., Colucci R., Antonioli L. et al. Effects of a bicarbonate-alkaline mineral water on digestive motility in experimental models of functional and inflammatory gastrointestinal disorders.Methods Find Exp Clin Pharmacol. 2008 May;30(4):261–9. https://dx.doi.org/10.1358/mf.2008.30.4.1159650
  4. Fraioli A., Menunni G., Petraccia L. et al. Sulphate-bicarbonate mineral waters in the treatment of biliary and digestive tract diseases. Clin Ter. 2010;161(2):163–8.
  5. Dupont C., Campagne A., Constant F. Efficacy and safety of a magnesium sulfate-rich natural mineral water for patients with functional constipation. Clin Gastroenterol Hepatol. 2014 Aug;12(8):1280–7. https://dx.doi.org/10.1016/j.cgh.2013.12.005
  6. Кручинина М.А., Пюрвеева К.В., Минушкин О.Н., Львова Н.В. Опыт применения минеральной воды «Донат Mg» в гастроэнтерологической практике. Медицинский совет. 2017;15:92–96. [Kruchinina M.A., Purveeva K.V., Minushkin O.N., Lvova N.V. Experience in using Donat Mg mineral water in gastroenterological practice. Meditsinskiy Sovet. 2017;15:92–6. (In Russ.)]. doi: 10.21518/2079-701X-2017-15-92-96
  7. Погорелова А.С. Роль минеральной воды «Донат Mg» в терапевтической практике. Медицинский совет. 2017;3:99–102. [Pogorelova A.S. The role of Donat Mg mineral water in therapeutic practice. Meditsinskiy Sovet. 2017;3:99–102. (In Russ.)]. https://dx.doi.org/10.21518/2079-701X-2017-3-99-102
  8. Куликов А.Г., Захарова И.Н., Творогова Т.М. и др. Применение магнийсодержащих минеральных вод при функциональных запорах у детей и подростков. Физиотерапия, бальнеология и реабилитация. 2018;5:272-278. [Kulikov A.G., Zakharova I.N., Tvorogova T.M. and others. The use of magnesium-containing mineral waters for functional constipation in children and adolescents. Physiotherapy, balneology and rehabilitation. 2018;5:272–78. (In Russ.)]. https://dx.doi.org/10.17816/1681-3456 2018-17-5-272-278
  9. Степурина Л.Л., Куликов А.Г., Захарова И.Н. и др. Применение магнийсодержащих минеральных вод при функциональных запорах у детей и подростков. Вестник физиотерапии и курортологии. 2019;4: 101-106. [Stepurina L.L., Kulikov A.G., Zakharova I.N. and others. The use of magnesium-containing mineral waters for functional constipation in children and adolescents. Bulletin of physiotherapy and balneology. 2019;4:101–6. (In Russ.)].
  10. Мубаракшина О.А., Елизарова И.О., Черенкова О.В. Эффективность применения природной минеральной воды DONAT в комплексной терапии нарушений липидного и углеводного обменов. Фарматека. 2023;3:64–69. [Mubarakshina O.A., Elizarova I.O., Cherenkov O.V. The effectiveness of the use of natural mineral water «Donat» in the complex therapy of lipid and carbohydrate metabolism disorders. Farmateka. 2023;3:64–9. (In Russ.)]. https://dx.doi.org/10.18565/pharmateca.2023.3.64-68.
  11. Мубаракшина О.А., Батищева Г.А., Щербова З.Р. Применение природной минеральной воды, богатой магнием и сульфатами, при функциональных запорах у взрослых и детей. Терапия. 2023;2:158–164. [Mubarakshina O.A., Batishcheva G.A., Shcherbova Z.R. The use of natural mineral water, rich in magnesium and sulfates, for functional constipation in adults and children. Therapy. 2023;2:158–64. (In Russ.)]. https://dx.doi.org/10.18565/therapy.2023.2.158-164
  12. Dupont C., Hébert G. Magnesium Sulfate-Rich Natural Mineral Waters in the Treatment of Functional Constipation-A Review. Nutrients. 2020 Jul 10;12(7):2052. doi: 10.3390/nu12072052
  13. Constant F., Morali A., Arnaud M.J., et al. Treatment of idiopathic constipation in infants: Comparative and randomized study of two mineral waters (60 cases) J. Pediatr. Gastroenterol. Nutr. 1999;28:551. https://dx.doi.org/10.1097/00005176-199905000-00052
  14. Dupont C., Campagne A., Constant F. Efficacy and safety of a magnesium sulfate-rich natural mineral water for patients with functional constipation. Clin. Gastroenterol. Hepatol. 2014;12:1280–1287. https://dx.doi.org/10.1016/j.cgh.2013.12.005
  15. Dupont C., Constant F., Imbert A., et al. Time to treatment response of a magnesium- and sulphate-rich natural mineral water in functional constipation. Nutrition. 2019;65:167–172. https://dx.doi.org/10.1016/j.nut.2019.02.018
  16. Naumann J., Sadaghiani C.D., Alt F., Huber R. Effects of Sulfate-Rich Mineral Water on Functional Constipation: A Double-Blind, Randomized, Placebo-Controlled Study. Complement. Med. Res. 2016;23:356–363. https://dx.doi.org/10.1159/000449436
  17. Bothe G., Coh A., Auinger A. Efficacy and safety of a natural mineral water rich in magnesium and sulphate for bowel function: A double-blind, randomized, placebo-controlled study. Eur. J. Nutr. 2015;56:491–499. https://dx.doi.org/10.1007/s00394-015-1094-8
  18. Боте Г., Чох А., Ауингер А. Эффективность и безопасность природной минеральной воды, богатой магнием и сульфатами, для функции кишечника. Рандомизированное плацебоконтролируемое двойное слепое исследование. Медицинский совет. 2016;14:100-8. [Bothe G., Coh A., Auinger A. Efficacy and safety of a natural mineral water rich in magnesium and sulphate for bowel function: A double-blind, randomized, placebo-controlled study Meditsinskiy Sovet. 2016;14:100-8. (In Russ.)]. https://dx.doi.org/10.21518/2079-701X-2016-14-100-108
  19. Gilca-Blanariu G.E., Trifan A., Ciocoiu M., et al. Magnesium-A Potential Key Player in Inflammatory Bowel Diseases? Nutrients. 2022 May 3;14(9):1914. https://dx.doi.org/10.3390/nu14091914
  20. Mennuni G., Petraccia L., Fontana M., et al. The therapeutic activity of sulphate-bicarbonate-calcium-magnesiac mineral water in the functional disorders of the biliary tract. Clin Ter. 2014;165(5):e346-52. https://dx.doi.org/10.7417/CT.2014.1761
  21. Захарова И.Н., Творогова Т.М., Мумладзе Э.Б. и др. Лечебная минеральная вода: от прошлого к будущему. Медицинский совет. 2015;14:106–13. [Zakharova I.N., Tvorogova T.M., Mumladze E.B. et al. Medicinal mineral water: from the past to the future. Meditsinskiy Sovet. 2015;14:106–13. (In Russ.)].
  22. Bohmer H., Müller H., Resch K.L. Calcium supplementation with calcium-rich mineral waters: a systematic review and meta-analysis of its bioavailability. Osteoporos Int. 2000;11(11):938–43. https://dx.doi.org/10.1007/s001980070032.
  23. Bertoni M., Olivieri F,. Manghetti M,. et al. Effects of a bicarbonate-alkaline mineral water on gastric functions and functional dyspepsia: a preclinical and clinical study. Pharmacol Res. 2002 Dec;46(6):525–31. https://dx.doi.org/10.1016/s1043661802002323
  24. Tepes B. The effects of Donat Mg natural mineral water on digestion and wider. Webinar: A Worlwide perspective on diagnosis and management of constipation: Challenges and solutions 2019.
  25. Luft F.C., Zemel M.B., Sowers J.A., et al. Sodium bicarbonate and sodium chloride: effects on blood pressure and electrolyte homeostasis in normal and hypertensive man. J Hypertens. 1990 Jul;8(7):663–70. https://dx.doi.org/10.1097/00004872-199007000-00010
  26. Petraccia L., Liberati G., Masciullo S.G., et al. Water, mineral waters and health. Clin Nutr. 2006 Jun;25(3):377–85. https://dx.doi.org/10.1016/j.clnu.2005.10.002
  27. Quattrini S., Pampaloni B., Brandi M.L. Natural mineral waters: chemical characteristics and health effects. Clin Cases Miner Bone Metab. 2016 Sep-Dec;13(3):173–180. https://dx.doi.org/10.11138/ccmbm/2016.13.3.173
  28. Bassotti G., Villanacci V., Corsetti M. Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future. J Clin Med. 2023 Feb 20;12(4):1702. https://dx.doi.org/10.3390/jcm12041702
  29. Drossman D.A. The Functional Gastrointestinal Disorders and the Rome III Process. Gastroenterology 2006;130(5):1377–90. https://dx.doi.org/10.1053/j.gastro.2006.03.008
  30. Коровина Н.А., Захарова И.Н., Гаврюшова Л.П. и др. Применение минеральной воды «Донат Mg» при соматической патологии у детей. Пособие для практикующих врачей-педиатров. М., 2005. 60 с. [Korovina N.A., Zakharova I.N., Gavryushova L.P. and others. The use of Donat Mg mineral water for somatic pathology in children. A manual for practicing pediatricians. M., 2005. 60 p. (In Russ.)].
  31. Захарова И.Н., Елезова Л.И., Степурина Л.Л. и др. Применение природной минеральной воды, обогащенной магнием, при лечении запоров у детей. Вопросы современной педиатрии, 2013;12(3):56–63. [Zakharova I.N., Elezova L.I., Stepurina L.L. et al. The use of natural mineral water enriched with magnesium in the treatment of constipation in children. Issues of modern pediatrics, 2013;12(3):56–63. (In Russ.)].
  32. Эфендиева М.Т., Бадшиева В.А., Русенко Н.И. Магнийсодержащие минеральные воды в лечении больных с кардиальными проявлениями гастроэзофагеальной рефлюксной болезни. Вопросы курортологии, физиотерапии и лечебной физкультуры, 2006;6:31–3. [Efendieva M.T., Badshieva V.A., Rusenko N.I. Magnesium-containing mineral waters in the treatment of patients with cardiac manifestations of gastroesophageal reflux disease. Issues of balneology, physiotherapy and physical therapy, 2006;6:31–3. (In Russ.)].
  33. Захарова И.Н., Куликов А.Г., Османов И.М. и др. Функциональный запор у детей: современные критерии диагностики и подходы к лечению. Педиатрия. Приложение к журналу Consilium Medicum. 2018;2:51–57. [Zakharova I.N., Kulikov A.G., Osmanov I.M. et al. Functional constipation in children: modern diagnostic criteria and approaches to treatment. Pediatrics. Consilium Medicum. 2018;2:51–7. (In Russ.)]. https://dx.doi.org/10.26442/2413-8460_2018.2.51-57
  34. Трухан Д.И., Рожкова М.Ю., Голошубина В.В. Хронический функциональный запор у пациентов молодого и среднего возраста: деликатная проблема – деликатное решение. Фарматека. 2023;30(1-2):44–53. Trukhan D.I., Rozhkova M.Yu., Goloshubina V.V. Chronic functional constipation in young and middle age patients: delicate problem – delicate decision. Farmateka. 2023;30(1-2):44-53. (In Russ.)]. https://dx.doi.org/10.18565/pharmateca.2023.1-2.44-53
  35. Bitoun A., Ponchon T., Barthet M., et al.; Norcol Group. Results of a prospective randomised multicentre controlled trial comparing a new 2-L ascorbic acid plus polyethylene glycol and electrolyte solution vs. sodium phosphate solution in patients undergoing elective colonoscopy. Aliment Pharmacol Ther. 2006 Dec;24(11-12):1631–42. https://dx.doi.org/10.1111/j.1365-2036.2006.03167.x
  36. Kilgore T.W., Abdinoor A.A., Szary N.M., et al. Bowel preparation with split-dose polyethylene glycol before colonoscopy: a meta-analysis of randomized controlled trials. Gastrointest Endosc. 2011 Jun;73(6):1240–5. https://dx.doi.org/10.1016/j.gie.2011.02.007
  37. Tepeš B., Mlakar D.N., Metličar T. Bowel preparation for colonoscopy with magnesium sulphate and low-volume polyethylene glycol. Eur J Gastroenterol Hepatol. 2014 Jun;26(6):616–20. https://dx.doi.org/10.1097/MEG.0000000000000093
  38. Фролков В.К. Новые представления о механизмах лечебно-профилактического действия питьевых минеральных вод. Клиническая медицина и фармакология. 2015;4:34-6. [Frolkov V.K. New ideas about the mechanisms of therapeutic and prophylactic action of drinking mineral waters. Clinical medicine and pharmacology. 2015;4:34–6. (In Russ.)].
  39. Фролков В.К. Механизмы влияния «Донат Mg» на обмен веществ и заболевания желудочно-кишечного тракта. [Frolkov V.K. Mechanisms of influence of “Donat Mg” on metabolism and diseases of the gastrointestinal tract. (In Russ.)]. URL: http://donatmg.ru/issledov/klinika/2009/09/29/klinika_13.html
  40. Фролков В.К. Влияние «Донат Mg» на резистентность слизистой желудка при действии стрессорных факторов. [Frolkov V.K. The effect of Donat Mg on the resistance of the gastric mucosa under the influence of stress factors. (In Russ.)]. URL: http://donatmg.ru/issledov/klinika/2009/09/29/klinika_12.html
  41. Балаболкин М.И. Изучение влияния «Донат Mg» на состояние больных инсулиннезависимым сахарным диабетом: информационно-методическое пособие. М., 2003. 12 с. [Balabolkin M.I. Study of the effect of “Donat Mg” on the condition of patients with non-insulin-dependent diabetes mellitus: information and methodological manual. M., 2003. 12 p. (In Russ.)].
  42. Мартынов А.И., Нечаева Г.И., Акатова Е.В. и др. Клинические рекомендации Российского научного медицинского общества терапевтов по диагностике, лечению и реабилитации пациентов с дисплазиями соединительной ткани (первый пересмотр). Медицинский вестник Северного Кавказа. 2018;13(1-2):137–209. [Martynov A.I., Nechaeva G.I., Akatova E.V., et al. Clinical recommendations of the Russian Scientific Medical Society of Therapists on the diagnosis, treatment and rehabilitation of patients with connective tissue dysplasias (first revision). Medicinskij vestnik Severnogo Kavkaza.2018;13(1-2):137–209. (In Russ.). https://dx.doi.org/10.14300/mnnc.2018.13037
  43. Акатова Е.В., Арутюнов Г.П., Баранов А.А. и др. Клинические рекомендации. Недифференцированные дисплазии соединительной ткани. Терапия. 2024;10(5S):1–43. [Akatova E.V., Arutyunov G.P., Baranov A.A., et al. Clinical guidelines. Undifferentiated connective tissue disease. Therapy. 2024;10(5S):1–43. (In Russ.)]. https://dx.doi.org/https://dx.doi.org/10.18565/therapy.2024.5suppl.1-43
  44. Мубаракшина О.А., Дронова Ю.М., Чернов С.Ю. Роль питьевой лечебной минеральной воды в поддержании функций пищеварительной системы. Терапия. 2024;4(76):165–173. [Mubarakshina O.A., Dronova Yu.M., Chernov S.Y. The role of drinking therapeutic mineral water in maintaining the functions of the digestive system. Therapy. 2024;4(76):165–173. (In Russ.)]. https://dx.doi.org/10.18565/therapy.2024.4.165-172
  45. Трухан Д.И., Рожкова М.Ю. Применение природной минеральной воды «Donat» при функциональных запорах и запорах у коморбидных пациентов. Фарматека. 2024;31(4):92–104. [Trukhan D.I., Rozhkova M.Yu. The use of natural mineral water “Donat” for functional constipation and constipation in comorbid patients. Farmateka. 2024;31(4):92–104. (In Russ.)]. https://dx.doi.org/10.18565/pharmateca.2024.4.92-104
  46. Яковлев В.М., Нечаева ГИ., Мартынов А.И., Викторова И.А. Дисплазия соединительной ткани в практике врачей первичного звена здравоохранения: руководство для врачей. М.: «КСТ Интерфорум», 2016. [Yakovlev V.M., Nechaeva G.I., Martynov A.I., Viktorova I.A. Connective tissue dysplasia in the practice of primary care physicians: a guide for doctors. M.: «KST Interforum», 2016. (In Russ.)].

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