Systemic HypertensionSystemic HypertensionСистемные гипертензии2075-082X2542-2189Intermedservice Ltd2870610.26442/SG28706ArticlesСтатьиResearch ArticleLegochnaya gipertenziya pri khronicheskoy obstruktivnoy bolezni legkikhЛегочная гипертензия при хронической обструктивной болезни легкихAvdeevS NАвдеевС ННИИ пульмонологии Минздрава РФ, Москва1503200411NO1 (2004)ТОМ 1, №1 (2004)51109042020Copyright ©; 2004, Consilium MedicumCopyright ©; 2004, ООО "Консилиум Медикум"2004Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://journals.eco-vector.com/2075-082X/article/view/28706

Хроническая обструктивная болезнь легких (ХОБЛ) является одной из ведущих причин заболеваемости и смертности во всем мире. ХОБЛ определяют как заболевание, характеризующееся ограничением воздушного потока, которое не полностью обратимо; ограничение воздушного потока обычно прогрессирует и связано с патологическим воспалительным ответом дыхательных путей на повреждающие частицы или газы . Легочная гипертензия (ЛГ) и ее прямое следствие – хроническое легочное сердце – являются наиболее частыми и прогностически неблагоприятными осложнениями ХОБЛ.Медикаментозная терапия при вторичных ЛГ должна быть направлена прежде всего на терапию основного заболевания, т.е. в данном случае у больных ХОБЛ необходимо использовать в полном объеме все средства для максимального улучшения бронхиальной проходимости, контроля за воспалением дыхательных путей и оптимизации показателей газообмена.В течение последних лет появились несколько перспективных препаратов, эффективность которых уже доказана у больных с первичной ЛГ. К числу таких препаратов относятся аналоги простациклина (илопрост, трепростенил, беропрост), антагонисты рецепторов эндотелина (бозентан).С учетом значительного повышения у больных ХОБЛ уровня эндотелина в крови, существуют теоретические предпосылки для использования антагонистов рецепторов эндотелина при ЛГ у данных больных.

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