Systemic HypertensionSystemic HypertensionСистемные гипертензии2075-082X2542-2189Intermedservice Ltd2874310.26442/SG28743ArticlesСтатьиResearch ArticleSindrom obstruktivnogo apnoe vo vremya sna i arterial'naya gipertenziyaСиндром обструктивного апноэ во время сна и артериальная гипертензияChazovaI EЧазоваИ ЕLitvinA YuЛитвинА ЮРоссийский кардиологический научно-производственный комплекс Росздрава, Институт кардиологии им. А.Л.Мясникова, Москва1503200631NO1 (2006)ТОМ 3, №1 (2006)31009042020Copyright ©; 2006, Consilium MedicumCopyright ©; 2006, ООО "Консилиум Медикум"2006Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://journals.eco-vector.com/2075-082X/article/view/28743

В последние годы исследователи уделяют все большее внимание синдрому обструктивного апноэ во время сна (СОАС), в частности его взаимосвязи с сердечно-сосудистыми заболеваниями, особенно с артериальной гипертензией (АГ) различного генеза. Стало очевидным, что СОАС является распространенной формой патологии и с ним связаны актуальные медицинские и социальные проблемы Взаимосвязь нарушений дыхания во время сна и заболеваний сердечно-сосудистой системы достаточно сложна, но углубление ее понимания имеет неоценимое значение для лечения огромного числа больных, у которых сочетаются эти патологические состояния. Хотя исследования последних лет значительно расширили наши познания в этой области, многие аспекты проблемы требуют дальнейшего изучения.

заболевания сердечно-сосудистой системынарушения дыханияартериальная гипертензиясиндром обструктивного апноэQuan S.F, Gersh B.J. Cardiovascular consequences of sleep - disordered breathing: past, present and future. Report of a Workshop from the National Center on Sleep Disorders Research and the National Heart, Lung, and Blood Institute. Circulation 2004; 109: 951-7.Gastaut H, Tassarini C, Duron B. Etudes polygraphiques des manifestations episodique (hypnique et respiratoire) du syndrome de Pickwick. Rev Neurol 1965; 112: 56-79.Jung R, Kuhlo W. Neuropsychological studies of abnormal night sleep and the Pickwickian syndrome. Prog Brain Res 1965; 18: 140-59.Mc Gregor M.I, Block A.J, Ball W.S. Serious complications and sudden death in the Pickwickian syndrome. Johns Hopkins Med J 1970; 126-7: 279-95.Guilleminault C, Eldridge F, Dement W.C. Insomnia with sleep apnea: a new syndrome. Science 1973; 181, 856-8.Finn L, Young T, Palta M, Fryback D.G. Sleep - disordered breathing and self - reported general health status in the Wisconsin Sleep Cohort Study. Sleep 1998; 21 (7): 701-6.Phillipson .A. Wake up, America. A Report of the National Commission on Sleep Disorders Research, 1993.Lugaresi E, Cirignotta F, Coccagna G, Piana C. Some epidemiological data on snoring and cardiocirculatory disturbances. Sleep 1980; 3 (3-4): 221-4.Lavie P, Ben-Yosef R, Rubin A.E. Prevalence of sleep apnea among patients with essential hypertension. Am Heart J 1984; 108: 373-6.Waller P, Bhopal R.S. Is snoring a cause of vascular disease? Lancet 1989; 1: 143-6.Hla K.M, Skatrud J.B, Finn L et al. The effect of correction of sleep - disordered breathing on BP in untreated hypertension. Chest 2002; 122: 1125-32.Young T, Palta M, Dempsey J et al. The occurrence of sleep disordered breathing among middle - aged adults. N Engl J Med 1993; 328: 1230-5.Peppard P.E, Young T, Palta M.P et al. Longitudinal study of moderate weight change and sleep disordered breathing. JAMA 2000; 282: 3015-21.Palmer L.J, Buxbau S.G, Larkin E.K et al. Whole genome scan for obstructive sleep apnea and obesity in African-American families. Am J Respir Crit Care Med 2004.Вейн А.М., Елигулашвили Т.С., Полуэктов М.Г. Синдром апноэ во сне. М.: "Эйдос-Медиа", 2002.Лопатин, А.С., Бузунов Р.В., Смушко А.М. и др. Храп и синдром обструктивного апноэ во сне. Рос. ринол. 1998; 4: 17-32.Калинкин А.Л. Синдром обструктивного апноэ сна - фактор риска артериальной гипертензии (обзор). Артериальн. гипертензия 2003; 9: 2: 37-41.Вейн А.М. Медицина сна (лекция). Кремлевская медицина. Клин. вестн. 1998; 5 (дополнит. номер): 70-2.Полуэктов М.Г. Ожирение и сон. В кн.: Ожирение. Под ред. И.И. Дедова и Г.А. Мельниченко. М.: Мед. информ. агентство, 2004; 312-29.Hedner J, Ejnell H, Sellgren J et al. Is high and fluctuating muscle - nerve sympathetic activity in the sleep apnea syndrome of pathogenetic importance for the development of hypertension? J Hypertens 1988; 6 (4): Suppl. 5520-37.Baylor P, Mouton A, Shamoon H.H, Goebel P. Increased norepinephrine variability in patients with sleep apnea syndrome. Am J Med 1995; 99: 6, 611-6.Lin C.C, Zan K.W, Lin C.Y. Plasma levels of atrial natriuretic factor in moderate to sever obstructive sleep apnea syndrome. Sleep 1993; 16 (1): 37-9.Aardweg van den J.G, Karemaker J.M. Repetitive apneas induce periodic hypertension in normal subjects through hypoxia. J Appl Physiol 1992; 72 (3): 821-7.Shimizu T, Kogava S, Tashiro T et al. Transient elevations of blood pressure in OSA. In: Home J., ed Sleep '90. Bochum, West Germany: Pontenagel; 1990; 182-4.Deegan P.C, Mc Nicolas W.T. Pathophysiology of obstructive sleep apnoea. Eur Respir J 1995; 8: 1161-78.Douglas N.J. The sleep apnea/hypopnea syndrome and snoring. ABC of sleep disorders. London: BMJ Publishing group, 1993; 19-22.Houvelingen van K.G., van Uffeln R, van Villet ACM. Sleep apnea syndrome (Review). Eur Heart J 1999; 20: 858-66.ASDA. A review: The indications for polysomnography and related procedures. Sleep, 1997; 20 (6): 423-67.American Academy of Sleep Medicine Task Force. Sleep - related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. Sleep 1999; 22: 667-89.Downey R 3rd, Perkin R.M, Mac Quarrie J. Upper airway resistance syndrome: sick, symptomatic but underrecognised. Sleep 1993;16 (7): 620-3.The international classification of sleep disorders: diagnostic and coding manual. Kansas: Allen Press Inc. 1990.Hoffstein V. Blood pressure, snoring, obesity, and nocturnal hypoxaemia. Lancet 1994; 344: 643-5.Fletcher E.C. Effect of episodic hypoxia on sympathetic activity and blood pressure. Respir Physiol 2000; 119 (2-3): 189-97.Nieto F.J, Young T.B, Lind B.K et al. Association of sleep - disordered breathing, sleep apnea and hypertension in a large community - based study. JAMA 2000; 283 (14): 1829-36.Peppard P.E, Young T, Palta M, Scatrud J. Prospective study of the association between sleep - disordered breathing and hypertension. New Engl J Med 2000; 342 (18): 1378-84.Brooks D, Horner L.F, Kozar C.L et al. Obstructive sleep apnea as a cause of systemic hypertension. Evidence from a canine model. J Clin Invest 1997; 99: 106-9.Yaseen A, Morgan B.J, Goodman B et al. Daytime blood pressure elevation after nocturnal hypoxia. J Appl Physiol 1999; 87 (2): 689-98.Kaufmann F, Annesi I, Neukirch V et al. The relation between snoring and smoking, body mass index, age, alcohol consumption and respiratory symptoms. Eur Resp J 1989; 2: 599-603.Kraiczi H, Hedner J, Peker Y, Grote L. Comparison of atenolol, amlodipine, enalapril, hydrochlorothiazide, and losartan for antihypertensive treatment in patients with obstructive sleep apnea. Am J Respir Crit Care Med 2000; 161 (5): 1423-8.Longstaff M. Mechanisms proposed whereby beta - blockers might worsen obstructive sleep apnoea. Respir Med 1999; 93 (4): 290-4.Pelttari L.H, Hietanen E.K, Salo T.T et al. Little effect of ordinary antihypertensive therapy on nocturnal high blood pressure in patients with sleep disordered breathing. Am J Hypertens 1998; 3 (Part 1): 272-6.Sullivan C.E, Issa F.G, Berton-Johnes M, Eves L. Reversal of obstructive sleep apnoea by continuous positive airway pressure therapy. Lancet 1981; I: 862-65.Berry R.B, Parish J.M, Hartse K.M. The use of auto - titrating continuous positive airway pressure for treatment of adult obstructive sleep apnea. Sleep 2002; 25: 1148-73.Reeves-Hoche M.K, Hudgel D.W, Meck R et al. A Ross Continuous versus bilevel positive airway pressure for obstructive sleep apnea Am J Respir Crit Care Med 1995; 151 (2): 443-9.Abdenbi F, Chambille B, Escourrou P. Bench testing of auto - adjusting positive airway pressure devices. Eur Respir J 2004; 24: 649-58.Mayer J, Becker H, Brandenburg U et al. Blood pressure and sleep apnea: Results of long - term nasal continuous positive airway pressure therapy. Cardiology 1991; 79: 84-92.Sanner B.M, Tepel M, Markmann A, Zidek W. Effect of continuous positive airway pressure therapy on 24-hour blood pressure in patients in patients with obstructive sleep apnea syndrome. Am J Hypertens 2002; 15: 251-6.Ip M.S, Lam K.S, Ho C et al. Serum leptin and vascular risk factors in obstructive sleep apnea. Chest 2000; 118: 580-6.Shimizu K, Chin K, Nakamura T et al. Plasma leptin levels and cardiac sympathetic function in patients with obstructive sleep apnoea - hypopnoea syndrome. Thorax 2002; 57: 429-34.Sanner B.M, Kollhosser P, Buechner N et al. Influence of treatment on leptin levels in patients with obstructive sleep apnoea. Eur Respir J 2004; 23 (4): 601-4.Brgel J, Sanner B.M, Keskin F et al. Obstructive sleep apnea and blood pressure. Am J Hyper 2004; 17 (12): 1081-7.White J, Cates C, Wright J. Continuous positive airways pressure for obstructive sleep apnoea (Cochrane Review). In: The Cochrane Library, Issue 1, 2004. Chichester, UK: John Wiley & S.