<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Systemic Hypertension</journal-id><journal-title-group><journal-title xml:lang="en">Systemic Hypertension</journal-title><trans-title-group xml:lang="ru"><trans-title>Системные гипертензии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-082X</issn><issn publication-format="electronic">2542-2189</issn><publisher><publisher-name xml:lang="en">Intermedservice Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">28959</article-id><article-id pub-id-type="doi">10.26442/SG28959</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The new widely discussed clinically significant aspects influence of β-blockers</article-title><trans-title-group xml:lang="ru"><trans-title>Новые широко обсуждаемые клинически значимые аспекты влияния b-блокаторов</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Arutyunov</surname><given-names>G P</given-names></name><name xml:lang="ru"><surname>Арутюнов</surname><given-names>Григорий Павлович</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф., зав. каф. терапии Московского факультета ГБОУ ВПО Российский национальный исследовательский медицинский университет им. Н.И.Пирогова, засл. врач РФ</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО РНИМУ им. Н.И.Пирогова Минздрава РФ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2013</year></pub-date><volume>10</volume><issue>1</issue><issue-title xml:lang="en">NO1 (2013)</issue-title><issue-title xml:lang="ru">ТОМ 10, №1 (2013)</issue-title><fpage>80</fpage><lpage>87</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/2075-082X/article/view/28959">https://journals.eco-vector.com/2075-082X/article/view/28959</self-uri><abstract xml:lang="en"><p>The use of b-blockers is of particular interest now. There are the pros and cons of prescribing these drugs. Thus, a considerable body of the papers that cast doubt on the role of b-blockers in elderly patients with arterial hypertension (AH) in preventing chronic heart failure and enhancing exercise endurance in patients with AH has been published since 2006–2008. However, the Russian guidelines have retained indications for the use of b-blockers that are indispensable drugs in the treatment of AH with high comorbidity. The paper analyzes the most studied b-blockers</p></abstract><trans-abstract xml:lang="ru"><p>Назначение β-блокаторов в настоящее время представляет особый интерес. Существуют доводы за и против назначения этих препаратов. Так, с 2006-2008 гг. было опубликовано значительное количество работ, поставивших под сомнение роль β-блокаторов у пожилых больных артериальной гипертензией (АГ), в предотвращении развития хронической сердечной недостатончости (ХСН) у больных АГ, в повышении переносимости физических нагрузок у больных АГ. Однако в российских рекомендациях β-блокаторы сохранили свои показания и являются обязательными препаратами в лечении пациентов, страдающих АГ с высокой коморбидностью. В статье приводится анализ наиболее изученных β-блокаторов</p></trans-abstract><kwd-group xml:lang="en"><kwd>b-blockers</kwd><kwd>metoprolol succinate</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>β-блокаторы</kwd><kwd>метопролола сукцинат</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Bangalore S, Sawhney S, Messerli F.H. Relation of beta - blocker - induced heart rate lowering and cardioprotection in hypertension. Cardiology 2008; 52 (18): 1482–9.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Bangalore S, Steg G, Deedwania P et al. b-Blocker use and clinical outcomes in stable outpatients with and without coronary artery disease JAMA 2012; 308 (13): 1340–9.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Nakamura M, Sato K, Nagano M. Estimation of aortic systolic blood pressure in community - based screening: the relationship between clinical characteristics and peripheral to central blood pressure differences. J Hum Hypertens 2005; 19: 251–3.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Roman M.J., Devereux R.B., Kizer J.R. High Central Pulse Pressure Is Independently Associated With Adverse Cardiovascular Outcome: The Strong Heart Study J Am Coll Cardiol 2009; 54 (18): 1730–4.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Rashmer R. Functional anatomy and control of the heart. Cardiovascular Dynamics 4th ed. Philadelphia: WB Saunders; 1975.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Фолков Б., Нил Э. Кровообращение. М.: Медицина, 1976.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Manisty C.H., Hughes A.D., Meta - analysis of the comparative effects of different classes of antihypertensive agents on brachial and central systolic blood pressure, and augmentation index. Br J Clin Pharmacol 2013; 75 (1): 79–92.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Williams B, Lacy P. for the CAFE and the ASCOT (Anglo - Scandinavian Cardiac Outcomes Trial) Investigators Impact of Heart Rate on Central Aortic Pressures and Hemodynamics Analysis From the CAFE (Conduit Artery Function Evaluation) Study: CAFE - Heart Rate. J Am Coll Cardiol 2009; 54: 705–13.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Williams B, Lacy P.S., Thom S.M. et al. Differential impact of blood pressure - lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation 2006; 113: 1213–25.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Kolloch R, Legler U.F., Champion A. et al. Impact of resting heart rate on outcomes in hypertensive patients with coronary artery disease: findings from the INternational VErapamil-SR/trandolapril STudy (INVEST) Eur Heart J 2008; 29 (10): 1327–34.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Poole-Wilson P.A., Swedberg K, Cleland JGF for the COMET investigators. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet 2003; 362: 7–13.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Ong K, Delerme S, Pannier B. et al. on behalf of the investigators. Аоtic stiffness is reduced beyond blood pressure lowering by short - term and long - term antihypertensive treatment: a meta - analysis of individual data in 294 patients. J Hypertension 2011; 29:1034–42.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Грибкова И.В., Шуберт Р., Серебряков В.П. NO активизирует Ca2+-активизируемый К+ ток гладкомышечных клеток хвостовой артерии крысы через GMP-зависимый механизм. Кардиология. 2002; 40 (8): 65–70.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Mongrain R, Cabau J.R. Role of Shear Stress in Atherosclerosis and Restenosis After Coronary Stent Implantation Revista Espanola de Card 2006; 59 (1): 1–4.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Lee C.S., Tarbell J.M. Influence of vasoactive drugs on wall shear stress distribution in the abdominal aortic bifurcation: an in vitro study. Ann Biomed Eng 1998; 26 (2): 200–12.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Gnasso A, Carallo C, Irace C. Association Between Intima–Media Thickness and Wall Shear Stress in Common Carotid Arteries in Healthy Male Subjects Circulation 1996; 94: 2–1489, 3257–62.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Kveiborg В, Hermann T, Atheline Major-Pedersen A et al. Metoprolol compared to carvedilol deteriorates insulin - stimulated endothelial function in patients with type 2 diabetes – a randomized study. Cardiovasc Diabetology 2010; 9: 21–30.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Falkner B, Kushner H. Treatment With Metoprolol Succinate, a Selective Beta Adrenergic Blocker, Lowers Blood Pressure Without Altering Insulin Sensitivity in Diabetic Patients The J Clin Hypertension 2008; 10 (1): 51–7.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Bakris G, Fonseca V, Katholi R et al. Metabolic Effects of Carvedilol vs Metoprolol in Patients With Type 2 Diabetes Mellitus and Hypertension: A Randomized Controlled Trial. JAMA 2004; 292: 2227–36.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Janka H.U., Ziegler A.G., Disselhoff G, Mehnert H. Influence of bisoprolol on blood glucose, glucosuria, and haemoglobin A1 in noninsulin - dependent diabetics. J Cardiovasc Pharmacol 1986; 8 (Suppl. 11): S96–9.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Hansson L, Lindholm L, Niskanen L. et al. Effect of angiotensin - converting - enzyme inhibition compared with conventional therapy on cardiovascular morbidity in hypertension: the Captopril Preventional Project (CAPP) randomised trial. Lancet 1999; 353: 611–6.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Adler A.I., Stratton I.M., Neil H. et al. on behalf of the UK Prospective Study group. Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study. BMJ 2000; 321: 412–9.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Agarval A, Haddad N, Hebert L.A. Progression of kidney disease: Diagnosis and management. In: Moloni D, Craig J eds. Evidence-Based Nephrology. Hoboken, NJ: Wiley 2003; 5 (2): 159–67; 2008; p. 311–22.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Sica D.A.The African American Study of Kidney Disease and Hypertension (AASK) trial: what more have we learned? J Clin Hypert 2003; 5 (2): 159–6723.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Messerli F.H., Grossman E, Goldbourt U. Are beta - blockers efficacious as first - line therapy for hypertension in the elderly? A systematic review. JAMA 1998; 279: 1903–7.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Dahlöf B, Devereux R.B., Kjeldsen S.E. et al. for the LIFE study group. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint Reduction in Hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002; 359: 995–1003.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Carlberg B, Samuelsson O, Lindholm L.H. Atenolol in hypertension: is it a wise choice? Lancet 2004; 364: 1684–9.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Dahlöf B, Sever P.S., Poulter N.R. et al. ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366: 895–906.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Lindholm L.H., Carlberg B, Samuelsson O. Should beta - blockers remain first choice in the treatment of primary hypertension? A meta - analysis. Lancet 2005; 366:1545–53.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Neutel J.M., Schnaper H, Cheung D.G. et al. Antihypertensive effects of beta - blockers administered once daily: 24-hour measurements. Am Heart J 1990; 120: 166–71.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Khan N, McAlister F.A. Re - examining the efficacy of beta - blockers for the treatment of hypertension: a meta - analysis. CMAJ 2006; 174: 1737–42.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Hjalmarson Å. Heart rate: An independent risk factor in cardiovascular disease. Eur Heart J 2007; 9 (Suppl. F): F3–7.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Jouven X, Empana J.P., Schwartz P.J. et al. Heart - rate profile during exercise as a predictor of sudden death. N Engl J Med 2005; 352: 1951–8.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Palatini P, Dorigatti F, Zaetta V et al. Heart rate as a predictor of development of sustained hypertension in subjects screened for stage 1 hypertension: The HARVEST Study. J Hypertens 2006; 24: 1873–80.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Aboyans V, Criqui M. Can we improve cardiovascular risk prediction beyond risk equations in the physician’s office? J Clin Epidemiol 2006; 59: 547–58.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Diaz A, Bourassa M.G., Guertin M.C., Tardif J.C. Long - term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease. Eur Heart J 2005; 26: 967–74.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Wieselgren I, Lundborg P, Sandberg A. et al. Pharmacokinetic and pharmacodynamic evaluation of metoprolol controlled release (CR/ZOK) 50 mg in young subjects J Clin Pharmacol 1990; 1 (30): S28–S32.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Schmieder R.E., Martus P, Klingbeil A. Reversal of left ventricular hypertrophy in essential hypertension. A meta - analysis of randomized double - blind studies. JAMA 1996; 275: 1507–13.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Klingbeil A, Schneider M, Martus P. et al. A meta - analysis of the effects of treatment on left ventricular mass in essential hypertension. Am J Med 2003; 115: 41–6.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Verza M, Ammendola S, Cambardella A et al. Regression of left ventricular hypertrophy in hypertensive elderly patients with carvedilol. Arch Gerontol Geriatr 1996; 22 (Suppl. 1): 143–7.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Hedblad B, Wikstrand J, Janzon L. et al. Low dose metoprolol CR/XL and fluvastatin slow progression of carotid intima - media thickness: main results from the Beta-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS). Circulation 2001; 103: 1721–6.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Marfella R, Siniscalchi M, Nappo F et al. Regression of carotid atherosclerosis by control of morning blood pressure peak in newly diagnosed hypertensive patients. Am J Hypertens 2005; 18: 308–31.</mixed-citation></ref></ref-list></back></article>
