Systemic HypertensionSystemic HypertensionСистемные гипертензии2075-082X2542-2189Intermedservice Ltd2907310.26442/SG29073ArticlesСтатьиResearch ArticleThe hardness of the vessel wall in patients with arterial hypertensionЖесткость сосудистой стенки у пациентов с артериальной гипертониейOstroumovaO DОстроумоваОльга Дмитриевна

д-р мед. наук, проф. каф. факультетской терапии и профболезней ГБОУ ВПО МГМСУ им. А.И.Евдокимова, проф. каф. клинической фармакологии и пропедевтики внутренних болезней ГБОУ ВПО Первый МГМУ им. И.М.Сеченова

ostroumova.olga@mail.ruKochetkovA IКочетковАлексей Иванович

ассистент каф. факультетской терапии и профболезней ГБОУ ВПО МГМСУ им. А.И.Евдокимова

ak_info@list.ruKopchenovI IКопченовИван Иванович

канд. мед. наук, доц. каф. факультетской терапии и профболезней ГБОУ ВПО МГМСУ им. А.И.Евдокимова

iik976@mail.ruGusevaT FГусеваТатьяна Федоровна

канд. мед. наук, доц. каф. факультетской терапии и профболезней ГБОУ ВПО МГМСУ им. А.И.Евдокимова

BondarecO VБондарецОльга Валентиновна

канд. мед. наук, доц. каф. факультетской терапии и профболезней ГБОУ ВПО МГМСУ им. А.И.Евдокимова

A.I.Evdokimov Moscow State Medical and Dental University of the Ministry of Health of the Russian FederationГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава РоссииI.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России15062015122VOL 12, NO2 (2015)ТОМ 12, №2 (2015)434809042020Copyright ©; 2015, Consilium MedicumCopyright ©; 2015, ООО "Консилиум Медикум"2015Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://journals.eco-vector.com/2075-082X/article/view/29073

The article deals with the role of the hardness of the vessel wall in the pathogenesis of arterial hypertension and its complications and cardiovascular mortality. We discussed the factors increasing the hardness of the vessel wall, such as age, blood pressure level, atherosclerosis, smoking and diabetes mellitus. We showed the indicators reflecting the status of the vascular wall and which could play a role of markers of increased risk of cardiovascular complications. We reviewed the data concerning the improvement of the parameters of the hardness of the vessel wall under the influence of antihypertensive therapy using the angiotensin II type 1 receptor blocker - candesartan. We discussed the possible mechanisms of the candesartan influence on the elastic properties of the vessels. We stressed that the effect on the hardness of the arteries on using antihypertensive drugs, even within the same class, was different, which, apparently, was associated with the difference in the pharmacokinetic properties.

В статье рассмотрена роль жесткости сосудистой стенки в патогенезе артериальной гипертонии, ее осложнений и сердечно-сосудистой смертности. Обсуждаются факторы, повышающие жесткость сосудистой стенки, - возраст, уровень артериального давления, атеросклероз, курение, сахарный диабет. Приведены показатели, которые отражают состояние сосудистой стенки и являются маркерами повышенного риска развития сердечно-сосудистых осложнений. Рассмотрены данные об улучшении параметров, характеризующих жесткость сосудистой стенки под влиянием антигипертензивной терапии блокатором рецепторов ангиотензина II 1-го типа кандесартаном. Обсуждаются возможные механизмы влияния кандесартана на эластические свойства сосудов. Подчеркивается, что эффект антигипертензивных медикаментов, даже относящихся к одному классу, на жесткость артерий разный, что, по-видимому, обусловлено различием в фармакокинетических свойствах.

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