Systemic HypertensionSystemic HypertensionСистемные гипертензии2075-082X2542-2189Intermedservice Ltd2910410.26442/SG29104ArticlesСтатьиResearch ArticleCentral and humoral mechanisms for arterial hypertension in womenЦентральные и гуморальные механизмы формирования артериальной гипертензии у женщинPodzolkovV IПодзолковВалерий Иванович

д-р мед. наук, проф., зав. каф. факультетской терапии №2 лечебного факультета ГБОУ ВПО Первый МГМУ им. И.М.Сеченова

BraginaA EБрагинаАнна Евгеньевна

канд. мед. наук, доц. каф. факультетской терапии №2 лечебного факультета ГБОУ ВПО Первый МГМУ им. И.М.Сеченова

anna.bragina@mail.ruRodionovaJ NРодионоваЮлия Нурисламовна

канд. мед. наук, ассистент каф. факультетской терапии №2 лечебного факультета ГБОУ ВПО Первый МГМУ им. И.М.Сеченова

KolodaJ AКолодаЮлия Алексеевна

ассистент каф. акушерства и гинекологии ГБОУ ДПО РМАПО

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава РоссииRussian Medical Academy of Post-diplom a Education of the Ministry of Health of the Russian FederationГБОУ ДПО Российская медицинская академия последипломного образования Минздрава России15032015121VOL 12, NO1 (2015)ТОМ 12, №1 (2015)768209042020Copyright ©; 2015, Consilium MedicumCopyright ©; 2015, ООО "Консилиум Медикум"2015Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://journals.eco-vector.com/2075-082X/article/view/29104

The article discusses various mechanisms of arterial hypertension (AH) development in postmenopausal women. It includes literature data on the sexual hormones, namely estrogen and progesterone deficit and androgen overproduction, influence on the blood pressure level and metabolic disorder. Special focus is on the role of renin-angiotensin-aldosterone system in AH pathogenesis. Separate paragraph is focused on the role autonomous nervous system dysfunction and disorders of biogenic amines metabolism in the vascular and autonomic disorders in climacteric syndrome, as well as the contribution of the humoral shifts typical for central obesity, such as hyperinsulinemia, and hyperleptinemia.

В статье обсуждаются разные механизмы развития артериальной гипертензии (АГ) у женщин в постменопаузе. Проанализированы литературные данные о влиянии половых гормонов, в том числе дефицита эстрогенов и прогестерона, избытка андрогенов на уровень артериального давления и метаболические параметры. Особое внимание уделено участию ренин-ангиотензин-альдостероновой системы в патогенезе АГ у женщин в перименопаузельном периоде. Отдельные разделы посвящены роли дисфункции вегетативной нервной системы и нарушений обмена биогенных аминов в формировании вегетативно-сосудистого симптомокомплекса в рамках климактерического синдрома, а также вкладу таких гуморальных сдвигов, характерных для центрального ожирения, как гиперинсулинемия и гиперлептинемия.

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